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• W2128548488 abstract "Argyrophilic nucleolar organizer region (AgNOR) counts in cytologic and histologic lymph node samples from healthy dogs and dogs with lymphoma were compared. Control samples were taken from 10 Beagle dogs (six female and four male dogs, 1.5–2 years), and lymphoma samples were taken from 16 dogs. Cytologic samples were obtained by fine-needle aspiration and impression and histologic samples by excision or incisional biopsy. Altogether, 26 cytologic, 19 excisional, and 7 incisional biopsy samples were examined. Lymph nodes of controls showed a moderate inflammatory pattern; of the lymphoma cases, nine were low-grade forms and seven were high-grade forms. Mean AgNOR counts per nucleus were determined. AgNOR counts were statistically different ( P < 0.001) between controls and lymphoma cases in cytologic (1.35 and 3.59, respectively) and histologic (1.4 and 2.89, respectively) samples. In lymphoma cases, AgNOR counts in cytologic samples were higher than those in histologic samples by 0.81 ( P < 0.001) and showed a linear relationship ( r = 0.6; P < 0.05) with the histologic counterparts in excisional biopsy samples. AgNOR counts in low- and high-grade lymphomas were significantly different ( P < 0.05) in cytologic (3.21 and 4.08, respectively) and histologic (2.68 and 3.18, respectively) samples. In conclusion, AgNOR counts were higher in lymph nodes with lymphoma than in reactive nodes. In the case of dogs with lymphoma, AgNOR counts in cytologic samples were linearly related to excisional but not to incisional biopsy samples. Although AgNOR counts were different between cytologic and histologic samples, either sample type provided enough sensitivity to differentiate between high- and low-grade forms of lymphoma." @default.
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• W2128548488 date "2004-07-01" @default.
• W2128548488 modified "2023-09-25" @default.
• W2128548488 title "Use of the Argyrophilic Nucleolar Region Method for Cytologic and Histologic Examination of the Lymph Nodes in Dogs" @default.
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• W2128548488 doi "https://doi.org/10.1354/vp.41-4-338" @default.
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