Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128559871> ?p ?o ?g. }
- W2128559871 endingPage "82" @default.
- W2128559871 startingPage "75" @default.
- W2128559871 abstract "Olanzapine is an atypical antipsychotic agent of the thienobenzodiazepine class. Olanzapine blocks multiple neurotransmitter receptors, including dopaminergic (D 1 , D 2 , D 3 , and D 4 ), serotonergic (5-hydroxytryptamine 2A [5-HT 2A ], 5-HT 2C , 5-HT 3 , and 5-HT 6 ), adrenergic (α 1 ), histaminic (H 1 ), and muscarinic (M 1 , M 2 , M 3 , and M 4 ) receptors. Olanzapine has a high affinity for the 5HT 2A receptor, which is up to 5 times greater than the dopamine receptor, resulting in less propensity to the development of extrapyramidal side effects. The affinity of olanzapine for multiple receptors has lead to the identification of olanzapine as an important agent in the treatment of delirium, nausea, and vomiting. Olanzapine has been demonstrated to have opioid-sparing properties. Olanzapine is principally metabolized by glucuronidation, with a smaller metabolic contribution from the cytochrome oxidase system. Adverse effects of olanzapine include somnolence, postural hypotension, constipation, dizziness, restlessness, and weight gain. The purpose of this article is to outline the pharmacodynamics, pharmacology, and evidence for the use of olanzapine in palliative care." @default.
- W2128559871 created "2016-06-24" @default.
- W2128559871 creator A5047528704 @default.
- W2128559871 date "2012-04-10" @default.
- W2128559871 modified "2023-10-17" @default.
- W2128559871 title "Olanzapine" @default.
- W2128559871 cites W1903277992 @default.
- W2128559871 cites W1969071740 @default.
- W2128559871 cites W1970803694 @default.
- W2128559871 cites W1973244660 @default.
- W2128559871 cites W1979980024 @default.
- W2128559871 cites W1985517071 @default.
- W2128559871 cites W2002826534 @default.
- W2128559871 cites W2004526114 @default.
- W2128559871 cites W2014508408 @default.
- W2128559871 cites W2018877551 @default.
- W2128559871 cites W2019017741 @default.
- W2128559871 cites W2027393266 @default.
- W2128559871 cites W2029309368 @default.
- W2128559871 cites W2031914339 @default.
- W2128559871 cites W2032238660 @default.
- W2128559871 cites W2033643297 @default.
- W2128559871 cites W2044131531 @default.
- W2128559871 cites W2045951807 @default.
- W2128559871 cites W2046773922 @default.
- W2128559871 cites W2059181308 @default.
- W2128559871 cites W2066209834 @default.
- W2128559871 cites W2073588187 @default.
- W2128559871 cites W2080945325 @default.
- W2128559871 cites W2095106622 @default.
- W2128559871 cites W2116571828 @default.
- W2128559871 cites W2122995608 @default.
- W2128559871 cites W2125145412 @default.
- W2128559871 cites W2125346945 @default.
- W2128559871 cites W2129439424 @default.
- W2128559871 cites W2158604806 @default.
- W2128559871 cites W2161032631 @default.
- W2128559871 cites W2166843397 @default.
- W2128559871 cites W2171958702 @default.
- W2128559871 cites W2333441088 @default.
- W2128559871 cites W46441896 @default.
- W2128559871 doi "https://doi.org/10.1177/1049909112441241" @default.
- W2128559871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22495793" @default.
- W2128559871 hasPublicationYear "2012" @default.
- W2128559871 type Work @default.
- W2128559871 sameAs 2128559871 @default.
- W2128559871 citedByCount "31" @default.
- W2128559871 countsByYear W21285598712012 @default.
- W2128559871 countsByYear W21285598712014 @default.
- W2128559871 countsByYear W21285598712015 @default.
- W2128559871 countsByYear W21285598712016 @default.
- W2128559871 countsByYear W21285598712017 @default.
- W2128559871 countsByYear W21285598712018 @default.
- W2128559871 countsByYear W21285598712019 @default.
- W2128559871 countsByYear W21285598712020 @default.
- W2128559871 countsByYear W21285598712021 @default.
- W2128559871 countsByYear W21285598712022 @default.
- W2128559871 crossrefType "journal-article" @default.
- W2128559871 hasAuthorship W2128559871A5047528704 @default.
- W2128559871 hasConcept C118552586 @default.
- W2128559871 hasConcept C126322002 @default.
- W2128559871 hasConcept C170493617 @default.
- W2128559871 hasConcept C2775864247 @default.
- W2128559871 hasConcept C2776412080 @default.
- W2128559871 hasConcept C2776619155 @default.
- W2128559871 hasConcept C2776921671 @default.
- W2128559871 hasConcept C2780494398 @default.
- W2128559871 hasConcept C2780616385 @default.
- W2128559871 hasConcept C53910766 @default.
- W2128559871 hasConcept C71924100 @default.
- W2128559871 hasConcept C98274493 @default.
- W2128559871 hasConceptScore W2128559871C118552586 @default.
- W2128559871 hasConceptScore W2128559871C126322002 @default.
- W2128559871 hasConceptScore W2128559871C170493617 @default.
- W2128559871 hasConceptScore W2128559871C2775864247 @default.
- W2128559871 hasConceptScore W2128559871C2776412080 @default.
- W2128559871 hasConceptScore W2128559871C2776619155 @default.
- W2128559871 hasConceptScore W2128559871C2776921671 @default.
- W2128559871 hasConceptScore W2128559871C2780494398 @default.
- W2128559871 hasConceptScore W2128559871C2780616385 @default.
- W2128559871 hasConceptScore W2128559871C53910766 @default.
- W2128559871 hasConceptScore W2128559871C71924100 @default.
- W2128559871 hasConceptScore W2128559871C98274493 @default.
- W2128559871 hasIssue "1" @default.
- W2128559871 hasLocation W21285598711 @default.
- W2128559871 hasLocation W21285598712 @default.
- W2128559871 hasOpenAccess W2128559871 @default.
- W2128559871 hasPrimaryLocation W21285598711 @default.
- W2128559871 hasRelatedWork W1982134688 @default.
- W2128559871 hasRelatedWork W1994768934 @default.
- W2128559871 hasRelatedWork W2032336977 @default.
- W2128559871 hasRelatedWork W2086612570 @default.
- W2128559871 hasRelatedWork W2132871355 @default.
- W2128559871 hasRelatedWork W2147009310 @default.
- W2128559871 hasRelatedWork W2240494951 @default.
- W2128559871 hasRelatedWork W2341846696 @default.
- W2128559871 hasRelatedWork W3081877424 @default.
- W2128559871 hasRelatedWork W4205873110 @default.