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- W2128585454 abstract "Hemorrhage within an intact abdominal cavity remains a leading cause of preventable death on the battlefield. Despite this need, there is no existing closed-cavity animal model to assess new hemostatic agents for the preoperative control of intra-abdominal hemorrhage.We developed a novel, lethal liver injury model in non-coagulopathic swine by strategic placement of two wire loops in the medial liver lobes including the hepatic and portal veins. Distraction resulted in grade V liver laceration with hepato-portal injury, massive bleeding, and severe hypotension. Crystalloid resuscitation was started once mean arterial pressure (MAP) fell below 65 mm Hg. Monitoring continued for up to 180 min.We demonstrated 90% lethality (9/10) in swine receiving injury and fluid resuscitation, with a mean survival time of 43 min. Previous efforts in our laboratory to develop a consistently lethal swine model of abdominal solid organs, including preemptive anticoagulation, a two-hit injury with controlled hemorrhage prior to liver trauma, and the injury described above without resuscitation, consistently failed to result in lethal injury.This model can be used to screen other interventions for pre hospital control of noncompressible." @default.
- W2128585454 created "2016-06-24" @default.
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- W2128585454 date "2013-06-01" @default.
- W2128585454 modified "2023-10-18" @default.
- W2128585454 title "Development of a lethal, closed-abdomen grade V hepato-portal injury model in non-coagulopathic swine" @default.
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- W2128585454 doi "https://doi.org/10.1016/j.jss.2012.07.048" @default.
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