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• W2128617961 abstract "Codon bias is a phenomenon that refers to the differences in the frequencies of synonymous codons among different genes. In many organisms, natural selection is considered to be a cause of codon bias because codon usage in highly expressed genes is biased toward optimal codons. Methods have previously been developed to predict the expression level of genes from their nucleotide sequences, which is based on the observation that synonymous codon usage shows an overall bias toward a few codons called major codons. However, the relationship between codon bias and gene expression level, as proposed by the translation-selection model, is less evident in mammals.We investigated the correlations between the expression levels of 1,182 mouse genes and amino acid composition, as well as between gene expression and codon preference. We found that a weak but significant correlation exists between gene expression levels and amino acid composition in mouse. In total, less than 10% of variation of expression levels is explained by amino acid components. We found the effect of codon preference on gene expression was weaker than the effect of amino acid composition, because no significant correlations were observed with respect to codon preference.These results suggest that it is difficult to predict expression level from amino acid components or from codon bias in mouse." @default.
• W2128617961 created "2016-06-24" @default.
• W2128617961 creator A5012384124 @default.
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• W2128617961 date "2011-01-27" @default.
• W2128617961 modified "2023-10-09" @default.
• W2128617961 title "Relationship between amino acid composition and gene expression in the mouse genome" @default.
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• W2128617961 doi "https://doi.org/10.1186/1756-0500-4-20" @default.
• W2128617961 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3038927" @default.
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