FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128624375> ?p ?o ?g. }

• W2128624375 abstract "Abstract Background The nuclear receptor superfamily currently consists of seven gene subfamilies that encompass over 80 distinct receptor proteins. These transcription factors typically share a common five-domain structure with a highly conserved DNA-binding domain. Some nuclear receptors are ubiquitous among the metazoans, while others are unique to specific phylogenetic groups. Crustaceans represent the second largest group of arthropods with insects being the largest. However, relative to insects, little is known about the nuclear receptors of crustaceans. The aim of this study was to identify putative nuclear receptors from the first assembled genome of a crustacean Daphnia pulex http://wFleaBase.org . Nuclear receptor expression was evaluated and receptors were subjected to phylogenetic analyses to gain insight into evolution and function. Results Twenty-five putative nuclear receptors were identified in D. pulex based on the presence of a conserved DNA-binding domain. All of the nuclear receptor protein sequences contain a highly homologous DNA-binding domain and a less conserved ligand-binding domain with the exception of the NR0A group. These receptors lack a ligand-binding domain. Phylogenetic analysis revealed the presence of all seven receptor subfamilies. The D. pulex genome contains several nuclear receptors that have vertebrate orthologs. However, several nuclear receptor members that are represented in vertebrates are absent from D. pulex . Notable absences include receptors of the 1C group (peroxisome proliferators-activated receptors), the 3A group (estrogen receptor), and the 3C group (androgen, progestogen, mineralcorticoid, and glucocorticoid receptors). The D. pulex genome also contains nuclear receptor orthologs that are present in insects and nematodes but not vertebrates, including putative nuclear receptors within the NR0A group. A novel group of receptors, designated HR97, was identified in D. pulex that groups with the HR96/CeNHR8/48/DAF12 clade, but forms its own sub-clade. Gene products were detected in adult female D. pulex for 21 of the 25 receptors. Conclusion Nuclear receptors are ancient proteins with highly conserved DNA-binding domains. The DNA-binding domains of the nuclear receptors of D. pulex contain the same degree of conservation that is typically found within nuclear receptors of other species. Most of the receptors identified in D. pulex have orthologs within the vertebrate and invertebrate lineages examined with the exception of the novel HR97 group and the Dappu-HR10 and potentially the Dappu-HR11 receptors found in D. pulex . These groups of receptors may harbour functions that are intrinsic to crustacean physiology." @default.
• W2128624375 created "2016-06-24" @default.
• W2128624375 creator A5012272194 @default.
• W2128624375 creator A5017610014 @default.
• W2128624375 creator A5034199251 @default.
• W2128624375 creator A5049632912 @default.
• W2128624375 creator A5077862729 @default.
• W2128624375 date "2009-10-28" @default.
• W2128624375 modified "2023-10-06" @default.
• W2128624375 title "Annotation, phylogenetics, and expression of the nuclear receptors in Daphnia pulex" @default.
• W2128624375 cites W1545165078 @default.
• W2128624375 cites W1545280767 @default.
• W2128624375 cites W1549327567 @default.
• W2128624375 cites W1586316126 @default.
• W2128624375 cites W1599762863 @default.
• W2128624375 cites W1921252126 @default.
• W2128624375 cites W1959798292 @default.
• W2128624375 cites W1964639921 @default.
• W2128624375 cites W1967008449 @default.
• W2128624375 cites W1969839676 @default.
• W2128624375 cites W1978385232 @default.
• W2128624375 cites W1983529756 @default.
• W2128624375 cites W1986619463 @default.
• W2128624375 cites W1987040411 @default.
• W2128624375 cites W1989546944 @default.
• W2128624375 cites W2005712554 @default.
• W2128624375 cites W2006560649 @default.
• W2128624375 cites W2007415064 @default.
• W2128624375 cites W2013327981 @default.
• W2128624375 cites W2016146562 @default.
• W2128624375 cites W2019670773 @default.
• W2128624375 cites W2022768206 @default.
• W2128624375 cites W2029031011 @default.
• W2128624375 cites W2030229259 @default.
• W2128624375 cites W2031883464 @default.
• W2128624375 cites W2033098747 @default.
• W2128624375 cites W2034036560 @default.
• W2128624375 cites W2041270901 @default.
• W2128624375 cites W2043808419 @default.
• W2128624375 cites W2045519188 @default.
• W2128624375 cites W2047063316 @default.
• W2128624375 cites W2050015093 @default.
• W2128624375 cites W2055043387 @default.
• W2128624375 cites W2061845709 @default.
• W2128624375 cites W2062018285 @default.
• W2128624375 cites W2063155821 @default.
• W2128624375 cites W2070155486 @default.
• W2128624375 cites W2071873664 @default.
• W2128624375 cites W2072712583 @default.
• W2128624375 cites W2074294717 @default.
• W2128624375 cites W2084214748 @default.
• W2128624375 cites W2096234478 @default.
• W2128624375 cites W2097382368 @default.
• W2128624375 cites W2098035462 @default.
• W2128624375 cites W2101040885 @default.
• W2128624375 cites W2101213596 @default.
• W2128624375 cites W2112614409 @default.
• W2128624375 cites W2115188607 @default.
• W2128624375 cites W2115621041 @default.
• W2128624375 cites W2115792493 @default.
• W2128624375 cites W2123126118 @default.
• W2128624375 cites W2123858984 @default.
• W2128624375 cites W2124285343 @default.
• W2128624375 cites W2125969054 @default.
• W2128624375 cites W2127902385 @default.
• W2128624375 cites W2128349500 @default.
• W2128624375 cites W2130209773 @default.
• W2128624375 cites W2134182205 @default.
• W2128624375 cites W2136689007 @default.
• W2128624375 cites W2137495261 @default.
• W2128624375 cites W2141508538 @default.
• W2128624375 cites W2141652419 @default.
• W2128624375 cites W2142693509 @default.
• W2128624375 cites W2146058063 @default.
• W2128624375 cites W2146373839 @default.
• W2128624375 cites W2148217900 @default.
• W2128624375 cites W2152741970 @default.
• W2128624375 cites W2153969356 @default.
• W2128624375 cites W2154403718 @default.
• W2128624375 cites W2158915039 @default.
• W2128624375 cites W2161441347 @default.
• W2128624375 cites W2161598420 @default.
• W2128624375 cites W2165910235 @default.
• W2128624375 cites W2166598224 @default.
• W2128624375 cites W2168483267 @default.
• W2128624375 cites W2171512505 @default.
• W2128624375 cites W2185890143 @default.
• W2128624375 cites W2234814159 @default.
• W2128624375 cites W2246856249 @default.
• W2128624375 cites W2589970558 @default.
• W2128624375 cites W2605614532 @default.
• W2128624375 cites W32813683 @default.
• W2128624375 cites W4240915622 @default.
• W2128624375 doi "https://doi.org/10.1186/1471-2164-10-500" @default.
• W2128624375 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2774871" @default.
• W2128624375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19863811" @default.
• W2128624375 hasPublicationYear "2009" @default.
• W2128624375 type Work @default.
• W2128624375 sameAs 2128624375 @default.
• W2128624375 citedByCount "79" @default.

• next