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• W2128626941 startingPage "4723" @default.
• W2128626941 abstract "Abstract C ryptosporidium is an apicomplexan protozoan that lives in most vertebrates, including humans. Its gp60 gene is functionally involved in its attachment to host cells, and its high level of genetic variation has made it the reference marker for sample typing in epidemiological studies. To understand the origin of such high diversity and to determine the extent to which this classification applies to the rest of the genome, we analysed the patterns of variation at gp60 and nine other nuclear loci in isolates of three C ryptosporidium species. Most loci showed low genetic polymorphism ( π S <1%) and similar levels of between‐species divergence. Contrastingly, gp60 exhibited very different characteristics: (i) it was nearly ten times more variable than the other loci; (ii) it displayed a significant excess of polymorphisms relative to between‐species differences in a maximum‐likelihood H udson– K reitman– A guadé test; (iii) gp60 subtypes turned out to be much older than the species they were found in; and (iv) showed a significant excess of polymorphic variants shared across species from random expectations. These observations suggest that this locus evolves under balancing selection and specifically under negative frequency‐dependent selection ( FDS ). Interestingly, genetic variation at the other loci clusters very well within the groups of isolates defined by gp60 subtypes, which may provide new tools to understand the genome‐wide patterns of genetic variation of the parasite in the wild. These results suggest that gp60 plays an active and essential role in the life cycle of the parasite and that genetic variation at this locus might be essential for the parasite's long‐term success." @default.
• W2128626941 created "2016-06-24" @default.
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• W2128626941 date "2013-08-05" @default.
• W2128626941 modified "2023-10-17" @default.
• W2128626941 title "Multilocus patterns of genetic variation across <i><scp>C</scp>ryptosporidium</i> species suggest balancing selection at the <i>gp60</i> locus" @default.
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• W2128626941 doi "https://doi.org/10.1111/mec.12425" @default.
• W2128626941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23915002" @default.
• W2128626941 hasPublicationYear "2013" @default.
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