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• W2128634047 abstract "Transcriptional activity of the 5′-flanking sequence of the human γ-glutamylcysteine synthetase heavy subunit (γ-GCSh) gene was investigated in COS7 cells transfected with hGH reporter constructs having successively deleted 5′-flanking sequence of the γ-GCShgene. Transcriptional activity was determined by the amounts of hGH secreted from the reporter constructs. Deletion of the sequence from −1,413 to −664 or −315 base pairs (bp) increased transcriptional activity from 100 to 138 or 136%. Further deletion from −315 to −241 bp, which contained an AP1 site, decreased transcriptional activity to 87%. Mutations introduced into the AP1 decreased transcriptional activity from 136 to 105%. These findings suggested that the AP1 increased transcriptional activity. When the sequence from −241 to −192 bp was deleted, transcriptional activity was restored from 87 to 128%. When this sequence was linked to the thymidine kinase promoter, it also decreased transcriptional activity by 38%. Deletion from −192 to −149, −116, or −108 bp did not significantly alter transcriptional activity. Further deletion of the GC-rich sequences from −108 to −70 and −28 bp dramatically decreased transcriptional activity from 135 to 87 and 34%, respectively. These findings indicate that multiple DNA elements, especially those in the proximal GC-rich sequences, are involved in the regulation of transcriptional activity of the γ-GCShgene." @default.
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• W2128634047 date "1997-03-01" @default.
• W2128634047 modified "2023-10-18" @default.
• W2128634047 title "Identification ofcis-Acting DNA Elements of the Human γ-Glutamylcysteine Synthetase Heavy Subunit Gene" @default.
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• W2128634047 doi "https://doi.org/10.1006/bbrc.1997.6319" @default.
• W2128634047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9125214" @default.
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