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• W2128649625 abstract "<b>Background:</b> The responsiveness of the endurance shuttle walk to functional changes following bronchodilation has recently been reported. The current literature suggests that the 6 min walking test (6MWT) is less responsive to bronchodilation than the endurance shuttle walk. <b>Aim:</b> To compare bronchodilator-induced changes in exercise performance with the 6MWT and the endurance shuttle walk. <b>Methods:</b> In a randomised, double-blind, placebo-controlled, crossover trial, 14 patients with chronic obstructive pulmonary disease (forced expiratory volume in 1 s (FEV₁) 50 (8)% predicted) completed two 6MWTs and two endurance shuttle walks, each preceded by nebulised placebo or 500 μg ipratropium bromide. Cardiorespiratory parameters were monitored during each walking test with a portable telemetric gas analyser. Quadriceps twitch force was measured by magnetic stimulation of the femoral nerve before and after each walking test. <b>Results:</b> The 6 min walking distance did not change significantly after bronchodilation despite a significant increase in FEV₁ of 0.18 (0.09) litres (p<0.001). A similar change in FEV₁ (0.18 (0.12) litres, p<0.001) was associated with a significant improvement in the distance walked on the endurance shuttle walk (Δdistance ipratropium bromide – placebo = 144 (219) m, p = 0.03). Quadriceps muscle fatigue was infrequent (<15% of patients) after both walking tests. <b>Conclusion:</b> The endurance shuttle walk is more responsive than the 6MWT for detecting changes in exercise performance following bronchodilation." @default.
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• W2128649625 date "2007-01-24" @default.
• W2128649625 modified "2023-10-15" @default.
• W2128649625 title "Six-minute walking versus shuttle walking: responsiveness to bronchodilation in chronic obstructive pulmonary disease" @default.
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• W2128649625 doi "https://doi.org/10.1136/thx.2006.065540" @default.
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