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- W2128665514 abstract "In today's medicine many decisions are based on data from the clinical chemistrylaboratory.Basically laboratory results for a specific constituent serve a dual purpose (35, 65):a. to recognize the diseased individual by relating the value found to either therange of values observed in a healthy population or to a range of values knownto be compatible with a specific condition.b. to monitor changes in an individual patient.Consequently measurements in clinical chemistry have to be reliable in two ways.Firstly, they have to be accurate, which is defined (I ,34a) as close to the true valueor an accepted reference value and secondly, they have to be precise, which means,that replicate test results have to agree closely (1,34a). The question that has oftenbeen discussed but hitherto not been answered satisfactory is: how accurate andhow precise do measurements in clinical chemistry have to be?In general in technical disciplines, requirements for accuracy and precision of measurementsare set by the consumer needs. For example in steel construction the consequencesof measurement errors are carefully considered. If the length of beams isincorrect or shows variations, all or some will not fit. If the actual shapes are smallerthan designed shapes or if the strength of the material is insufficient the constructionmay collapse. If the strength/weight ratio is low the beams will be too expensiveto meet the budget. Technical and economical consequences of each deviation fromthe ideal or required dimensions can be calculated, and, not unimportant, instrumentsused for measurements are adequate to register these deviations.In clinical chemistry consumer needs are more difficult to define.Firstly, ideal or required values are difficult to establish.Secondly, clinical chemistry measurements are seldom carried out with impeccableaccuracy and precision." @default.
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- W2128665514 date "1978-01-11" @default.
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- W2128665514 title "Requirements for analytical performance in clinical chemistry : an evaluation from the point of view of the practicing physician" @default.
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