FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128672442> ?p ?o ?g. }

• W2128672442 endingPage "523" @default.
• W2128672442 startingPage "518" @default.
• W2128672442 abstract "Diabetes is considered a risk factor in the osseointegration of dental implants, which suggests that these patients might benefit from anabolic therapies. Preclinical studies, including investigations by this research group, revealed that intermittent administration of parathyroid hormone (PTH) stimulates bone formation on the surface of titanium implants under physiological conditions. However, the anabolic effect of PTH on osseointegration under the hyperglycemic condition of diabetes is unknown.The ability of PTH to stimulate osseointegration was investigated in 40 female Wistar rats that were randomly divided into the following treatment groups: diabetes, diabetes plus PTH, control, and control plus PTH. Diabetes was induced by intraperitoneal injection of streptozotocin (45 mg/kg) at 1 week before implantation. Rats received PTH at a dose of 60 μg/kg or a vehicle by subcutaneous injection starting at the day of implant insertion into the tibia. Histomorphometric analysis was performed after 4 weeks.The medullary peri-implant bone area significantly increased in rats receiving PTH in comparison with the control group (41±12% to 20±12%; P<0.01). Moreover, there was an increased bone-to-implant contact (BIC) area in animals treated with PTH (47±18% to 27±16%; P<0.05). In contrast, diabetic rats failed to benefit from the anabolic treatment. A similar peri-implant bone area occurred in the diabetes group, independent of treatment with PTH (13±9% to 15±6%; P>0.05). Moreover, PTH did not affect the BIC area under hyperglycemic conditions (16±12% to 16±8%; P>0.05). No significant changes were observed in the cortical compartment of all groups.These results demonstrate that the metabolic characteristics of the diabetic rats produced a condition that was unable to respond to PTH treatment. These findings led us to hypothesize that metabolic control of diabetes might be a critical determinant when diabetic patients are undergoing anabolic therapy to enhance osseointegration." @default.
• W2128672442 created "2016-06-24" @default.
• W2128672442 creator A5004800475 @default.
• W2128672442 creator A5014940484 @default.
• W2128672442 creator A5016370218 @default.
• W2128672442 creator A5034445155 @default.
• W2128672442 creator A5054703368 @default.
• W2128672442 creator A5090743295 @default.
• W2128672442 date "2011-01-20" @default.
• W2128672442 modified "2023-10-16" @default.
• W2128672442 title "Intermittent parathyroid hormone fails to stimulate osseointegration in diabetic rats" @default.
• W2128672442 cites W1966994557 @default.
• W2128672442 cites W1996320866 @default.
• W2128672442 cites W1996656034 @default.
• W2128672442 cites W2001956022 @default.
• W2128672442 cites W2012886548 @default.
• W2128672442 cites W2015859975 @default.
• W2128672442 cites W2023219050 @default.
• W2128672442 cites W2043523332 @default.
• W2128672442 cites W2054180787 @default.
• W2128672442 cites W2057797464 @default.
• W2128672442 cites W2059094114 @default.
• W2128672442 cites W2060336303 @default.
• W2128672442 cites W2068155960 @default.
• W2128672442 cites W2077759995 @default.
• W2128672442 cites W2080130618 @default.
• W2128672442 cites W2082379706 @default.
• W2128672442 cites W2087378917 @default.
• W2128672442 cites W2092369211 @default.
• W2128672442 cites W2099410624 @default.
• W2128672442 cites W2099453231 @default.
• W2128672442 cites W2115991999 @default.
• W2128672442 cites W2116515339 @default.
• W2128672442 cites W2132554143 @default.
• W2128672442 cites W2134478449 @default.
• W2128672442 cites W2140672532 @default.
• W2128672442 cites W2144746122 @default.
• W2128672442 cites W2152347337 @default.
• W2128672442 cites W2155821999 @default.
• W2128672442 cites W2171504172 @default.
• W2128672442 cites W2171702898 @default.
• W2128672442 cites W2335178464 @default.
• W2128672442 doi "https://doi.org/10.1111/j.1600-0501.2010.02047.x" @default.
• W2128672442 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21251075" @default.
• W2128672442 hasPublicationYear "2011" @default.
• W2128672442 type Work @default.
• W2128672442 sameAs 2128672442 @default.
• W2128672442 citedByCount "21" @default.
• W2128672442 countsByYear W21286724422012 @default.
• W2128672442 countsByYear W21286724422013 @default.
• W2128672442 countsByYear W21286724422014 @default.
• W2128672442 countsByYear W21286724422015 @default.
• W2128672442 countsByYear W21286724422016 @default.
• W2128672442 countsByYear W21286724422018 @default.
• W2128672442 countsByYear W21286724422020 @default.
• W2128672442 countsByYear W21286724422021 @default.
• W2128672442 countsByYear W21286724422022 @default.
• W2128672442 crossrefType "journal-article" @default.
• W2128672442 hasAuthorship W2128672442A5004800475 @default.
• W2128672442 hasAuthorship W2128672442A5014940484 @default.
• W2128672442 hasAuthorship W2128672442A5016370218 @default.
• W2128672442 hasAuthorship W2128672442A5034445155 @default.
• W2128672442 hasAuthorship W2128672442A5054703368 @default.
• W2128672442 hasAuthorship W2128672442A5090743295 @default.
• W2128672442 hasBestOaLocation W21286724421 @default.
• W2128672442 hasConcept C1008401 @default.
• W2128672442 hasConcept C101414908 @default.
• W2128672442 hasConcept C126322002 @default.
• W2128672442 hasConcept C134018914 @default.
• W2128672442 hasConcept C141071460 @default.
• W2128672442 hasConcept C195121873 @default.
• W2128672442 hasConcept C2779280383 @default.
• W2128672442 hasConcept C2781208988 @default.
• W2128672442 hasConcept C2781411149 @default.
• W2128672442 hasConcept C519063684 @default.
• W2128672442 hasConcept C555293320 @default.
• W2128672442 hasConcept C71924100 @default.
• W2128672442 hasConceptScore W2128672442C1008401 @default.
• W2128672442 hasConceptScore W2128672442C101414908 @default.
• W2128672442 hasConceptScore W2128672442C126322002 @default.
• W2128672442 hasConceptScore W2128672442C134018914 @default.
• W2128672442 hasConceptScore W2128672442C141071460 @default.
• W2128672442 hasConceptScore W2128672442C195121873 @default.
• W2128672442 hasConceptScore W2128672442C2779280383 @default.
• W2128672442 hasConceptScore W2128672442C2781208988 @default.
• W2128672442 hasConceptScore W2128672442C2781411149 @default.
• W2128672442 hasConceptScore W2128672442C519063684 @default.
• W2128672442 hasConceptScore W2128672442C555293320 @default.
• W2128672442 hasConceptScore W2128672442C71924100 @default.
• W2128672442 hasIssue "5" @default.
• W2128672442 hasLocation W21286724421 @default.
• W2128672442 hasLocation W21286724422 @default.
• W2128672442 hasOpenAccess W2128672442 @default.
• W2128672442 hasPrimaryLocation W21286724421 @default.
• W2128672442 hasRelatedWork W1970861121 @default.
• W2128672442 hasRelatedWork W1995071802 @default.
• W2128672442 hasRelatedWork W2005086919 @default.
• W2128672442 hasRelatedWork W2011709829 @default.

• next