FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128673805> ?p ?o ?g. }

• W2128673805 endingPage "8355" @default.
• W2128673805 startingPage "8343" @default.
• W2128673805 abstract "Gene regulation by dioxins is mediated via the dioxin receptor, a ligand-dependent basic helix-loop-helix (bHLH)/PAS transcription factor. The latent dioxin receptor responds to dioxin signalling by forming an activated heterodimeric complex with a specific bHLH partner, Arnt, an essential process for target DNA recognition. We have analyzed the transactivating potential within this heterodimeric complex by dissecting it into individual subunits, replacing the dimerization and DNA-binding bHLH motifs with heterologous zinc finger DNA-binding domains. The uncoupled Arnt chimera, maintaining 84% of Arnt residues, forms a potent and constitutive transcription factor. Chimeric proteins show that the dioxin receptor also harbors a strong transactivation domain in the C terminus, although this activity was silenced by inclusion of 82 amino acids from the central ligand-binding portion of the dioxin receptor. This central repression region conferred binding of the molecular chaperone hsp90 upon otherwise constitutive chimeras in vitro, indicating that hsp90 has the ability to mediate a cis-repressive function on distant transactivation domains. Importantly, when the ligand-binding domain of the dioxin receptor remained intact, the ability of this hsp90-binding activity to confer repression became conditional rather than irreversible. Our data are consistent with a model in which crucial activities of the dioxin receptor, such as dimerization with Arnt and transactivation, are conditionally repressed by the central ligand- and-hsp90-binding region of the receptor. In contrast, the Arnt protein appears to be free from any repressive activity. Moreover, within the context of the dioxin response element (xenobiotic response element), the C terminus of Arnt conferred a potent, dominating transactivation function onto the native bHLH heterodimeric complex. Finally, the relative transactivation potencies of the individual dioxin receptor and Arnt chimeras varied with cell type and promoter architecture, indicating that the mechanisms for transcriptional activation may differ between these two subunits and that in the native complex the transactivation pathway may be dependent upon cell-specific and promoter contexts." @default.
• W2128673805 created "2016-06-24" @default.
• W2128673805 creator A5036193907 @default.
• W2128673805 creator A5050720617 @default.
• W2128673805 creator A5082257089 @default.
• W2128673805 date "1994-12-01" @default.
• W2128673805 modified "2023-10-18" @default.
• W2128673805 title "Identification of transactivation and repression functions of the dioxin receptor and its basic helix-loop-helix/PAS partner factor Arnt: inducible versus constitutive modes of regulation." @default.
• W2128673805 cites W1213045642 @default.
• W2128673805 cites W1505278126 @default.
• W2128673805 cites W1516006437 @default.
• W2128673805 cites W1530358119 @default.
• W2128673805 cites W1566112956 @default.
• W2128673805 cites W1576236282 @default.
• W2128673805 cites W1576929531 @default.
• W2128673805 cites W1622053312 @default.
• W2128673805 cites W1671652918 @default.
• W2128673805 cites W1675449053 @default.
• W2128673805 cites W1723187988 @default.
• W2128673805 cites W1748456144 @default.
• W2128673805 cites W1771969432 @default.
• W2128673805 cites W1794066632 @default.
• W2128673805 cites W1838929416 @default.
• W2128673805 cites W1900251589 @default.
• W2128673805 cites W1935728713 @default.
• W2128673805 cites W1969656285 @default.
• W2128673805 cites W1973865007 @default.
• W2128673805 cites W1978754402 @default.
• W2128673805 cites W1979697640 @default.
• W2128673805 cites W1980214543 @default.
• W2128673805 cites W1982265633 @default.
• W2128673805 cites W1985006541 @default.
• W2128673805 cites W1989429141 @default.
• W2128673805 cites W1995551499 @default.
• W2128673805 cites W1996454474 @default.
• W2128673805 cites W1999662020 @default.
• W2128673805 cites W2015216297 @default.
• W2128673805 cites W2017133589 @default.
• W2128673805 cites W2036360644 @default.
• W2128673805 cites W2043408306 @default.
• W2128673805 cites W2058649944 @default.
• W2128673805 cites W2067627058 @default.
• W2128673805 cites W2068577315 @default.
• W2128673805 cites W2085643470 @default.
• W2128673805 cites W2087332917 @default.
• W2128673805 cites W2094230077 @default.
• W2128673805 cites W2101071262 @default.
• W2128673805 cites W2101408825 @default.
• W2128673805 cites W2129722957 @default.
• W2128673805 cites W2135564507 @default.
• W2128673805 cites W2296154126 @default.
• W2128673805 cites W4705614 @default.
• W2128673805 cites W54771977 @default.
• W2128673805 doi "https://doi.org/10.1128/mcb.14.12.8343" @default.
• W2128673805 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/359373" @default.
• W2128673805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7969169" @default.
• W2128673805 hasPublicationYear "1994" @default.
• W2128673805 type Work @default.
• W2128673805 sameAs 2128673805 @default.
• W2128673805 citedByCount "119" @default.
• W2128673805 countsByYear W21286738052012 @default.
• W2128673805 countsByYear W21286738052013 @default.
• W2128673805 countsByYear W21286738052015 @default.
• W2128673805 countsByYear W21286738052016 @default.
• W2128673805 countsByYear W21286738052018 @default.
• W2128673805 countsByYear W21286738052020 @default.
• W2128673805 countsByYear W21286738052022 @default.
• W2128673805 countsByYear W21286738052023 @default.
• W2128673805 crossrefType "journal-article" @default.
• W2128673805 hasAuthorship W2128673805A5036193907 @default.
• W2128673805 hasAuthorship W2128673805A5050720617 @default.
• W2128673805 hasAuthorship W2128673805A5082257089 @default.
• W2128673805 hasBestOaLocation W21286738051 @default.
• W2128673805 hasConcept C104317684 @default.
• W2128673805 hasConcept C1292079 @default.
• W2128673805 hasConcept C150194340 @default.
• W2128673805 hasConcept C153911025 @default.
• W2128673805 hasConcept C186310378 @default.
• W2128673805 hasConcept C205260736 @default.
• W2128673805 hasConcept C2775932338 @default.
• W2128673805 hasConcept C33594762 @default.
• W2128673805 hasConcept C45815257 @default.
• W2128673805 hasConcept C55493867 @default.
• W2128673805 hasConcept C6174537 @default.
• W2128673805 hasConcept C86339819 @default.
• W2128673805 hasConcept C86803240 @default.
• W2128673805 hasConcept C94966510 @default.
• W2128673805 hasConcept C95444343 @default.
• W2128673805 hasConceptScore W2128673805C104317684 @default.
• W2128673805 hasConceptScore W2128673805C1292079 @default.
• W2128673805 hasConceptScore W2128673805C150194340 @default.
• W2128673805 hasConceptScore W2128673805C153911025 @default.
• W2128673805 hasConceptScore W2128673805C186310378 @default.
• W2128673805 hasConceptScore W2128673805C205260736 @default.
• W2128673805 hasConceptScore W2128673805C2775932338 @default.
• W2128673805 hasConceptScore W2128673805C33594762 @default.
• W2128673805 hasConceptScore W2128673805C45815257 @default.
• W2128673805 hasConceptScore W2128673805C55493867 @default.

• next