Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128677082> ?p ?o ?g. }
- W2128677082 endingPage "224" @default.
- W2128677082 startingPage "216" @default.
- W2128677082 abstract "Abstract The present study examined the anti-proliferative properties of aqueous (WESM), ethanolic (EESM) and supercritical carbon dioxide (SCESM-5) extracts of Salvia miltiorrhiza in 3T3-L1 adipocytes, and the contents of bioactive compounds salvianolic acid B (SAB), cryptotanshinone (CTS), tanshinone I (TS-I) and tanshinone IIA (TS-IIA). Results showed that WESM contained mainly SAB, whereas EESM possessed all the four bioactive compounds, but its concentrations of CTS, TS-I and TS-IIA were 2–3-fold lower than SCESM-5. SCESM-5 demonstrated the most potent inhibitory effect on 3T3-L1 cell proliferation, and induction of cell apoptosis and cell cycle arrest. Further studies showed that it enhanced intracellular ROS level, down-regulated CD95 (APO-1/CD95), Bcl-2 and PPAR-γ, up-regulated Bax, AMPK and p-AMPK, and caused activation of caspase-3 and PARP cleavage, as well as JNK and ERK activation and phosphorylation. Pretreatments with antioxidant (Vit E), caspase-3 (z-DEVD-fmk) and ERK (PD98059) inhibitors significantly suppressed the SCESM-5-induced ROS production and cell death. Caspase-3 inhibitor efficiently blocked the Bax expression, caspase-3 activation and PARP cleavage, while ERK inhibitor suppressed the ERK phosphorylation after SCESM-5 treatment. This study concludes that CTS, TS-I and TS-IIA of SCESM-5 may have contributed to the potent anti-proliferative activity through the MAPK and AMPK pathways in 3T3-L1 adipocytes." @default.
- W2128677082 created "2016-06-24" @default.
- W2128677082 creator A5014747469 @default.
- W2128677082 creator A5021303141 @default.
- W2128677082 creator A5024215726 @default.
- W2128677082 creator A5072613061 @default.
- W2128677082 creator A5080223032 @default.
- W2128677082 creator A5082259017 @default.
- W2128677082 date "2012-02-01" @default.
- W2128677082 modified "2023-09-23" @default.
- W2128677082 title "Bioactive constituents and anti-proliferative properties of supercritical carbon dioxide Salvia miltiorrhiza extract in 3T3-L1 adipocytes" @default.
- W2128677082 cites W1571529930 @default.
- W2128677082 cites W1576135444 @default.
- W2128677082 cites W1758437761 @default.
- W2128677082 cites W1969209081 @default.
- W2128677082 cites W1971386010 @default.
- W2128677082 cites W1973614704 @default.
- W2128677082 cites W1973677547 @default.
- W2128677082 cites W1975288342 @default.
- W2128677082 cites W1983830700 @default.
- W2128677082 cites W1983890824 @default.
- W2128677082 cites W1988317357 @default.
- W2128677082 cites W1993137708 @default.
- W2128677082 cites W1995986855 @default.
- W2128677082 cites W1998963478 @default.
- W2128677082 cites W2002006853 @default.
- W2128677082 cites W2002682915 @default.
- W2128677082 cites W2003530465 @default.
- W2128677082 cites W2012390470 @default.
- W2128677082 cites W2016310489 @default.
- W2128677082 cites W2023714210 @default.
- W2128677082 cites W2029939478 @default.
- W2128677082 cites W2031578694 @default.
- W2128677082 cites W2033577451 @default.
- W2128677082 cites W203949027 @default.
- W2128677082 cites W2041205764 @default.
- W2128677082 cites W2041335773 @default.
- W2128677082 cites W2046188137 @default.
- W2128677082 cites W2046631904 @default.
- W2128677082 cites W2046951830 @default.
- W2128677082 cites W2048132098 @default.
- W2128677082 cites W2048426126 @default.
- W2128677082 cites W2050866010 @default.
- W2128677082 cites W2053699902 @default.
- W2128677082 cites W2054938170 @default.
- W2128677082 cites W2058080431 @default.
- W2128677082 cites W2058488021 @default.
- W2128677082 cites W2062663016 @default.
- W2128677082 cites W2067870508 @default.
- W2128677082 cites W2072252062 @default.
- W2128677082 cites W2073171519 @default.
- W2128677082 cites W2073525091 @default.
- W2128677082 cites W2074472079 @default.
- W2128677082 cites W2075931876 @default.
- W2128677082 cites W2080981566 @default.
- W2128677082 cites W2084060660 @default.
- W2128677082 cites W2087135491 @default.
- W2128677082 cites W2087659536 @default.
- W2128677082 cites W2092417545 @default.
- W2128677082 cites W2092444344 @default.
- W2128677082 cites W2095902786 @default.
- W2128677082 cites W2096047391 @default.
- W2128677082 cites W2102891343 @default.
- W2128677082 cites W2113834570 @default.
- W2128677082 cites W2128627308 @default.
- W2128677082 cites W2142688280 @default.
- W2128677082 cites W2143944971 @default.
- W2128677082 cites W2151385330 @default.
- W2128677082 cites W2154058662 @default.
- W2128677082 cites W2154066769 @default.
- W2128677082 cites W2155683415 @default.
- W2128677082 cites W2169188936 @default.
- W2128677082 cites W2171651779 @default.
- W2128677082 cites W2339169589 @default.
- W2128677082 cites W31174208 @default.
- W2128677082 cites W93632731 @default.
- W2128677082 doi "https://doi.org/10.1016/j.procbio.2011.10.034" @default.
- W2128677082 hasPublicationYear "2012" @default.
- W2128677082 type Work @default.
- W2128677082 sameAs 2128677082 @default.
- W2128677082 citedByCount "7" @default.
- W2128677082 countsByYear W21286770822013 @default.
- W2128677082 countsByYear W21286770822016 @default.
- W2128677082 countsByYear W21286770822019 @default.
- W2128677082 crossrefType "journal-article" @default.
- W2128677082 hasAuthorship W2128677082A5014747469 @default.
- W2128677082 hasAuthorship W2128677082A5021303141 @default.
- W2128677082 hasAuthorship W2128677082A5024215726 @default.
- W2128677082 hasAuthorship W2128677082A5072613061 @default.
- W2128677082 hasAuthorship W2128677082A5080223032 @default.
- W2128677082 hasAuthorship W2128677082A5082259017 @default.
- W2128677082 hasConcept C118419359 @default.
- W2128677082 hasConcept C134458231 @default.
- W2128677082 hasConcept C142536801 @default.
- W2128677082 hasConcept C142724271 @default.
- W2128677082 hasConcept C171089720 @default.
- W2128677082 hasConcept C178790620 @default.
- W2128677082 hasConcept C185592680 @default.