Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128705539> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2128705539 endingPage "3065" @default.
- W2128705539 startingPage "3061" @default.
- W2128705539 abstract "Background: Rac3, a member of the Rac family of small guanosine triphosphatases (GTPases), regulates a variety of cell functions, including the organization of the cytoskeleton, cell migration, and invasion. Overexpression of Rac3 has been reported in several human cancers. However, the role of Rac3 in lung cancer (LC) has not been determined in detail. The purpose of this study was to investigate the effect of silencing of Rac3 expression in human LC cells and the consequences for cell survival. Materials and Methods: Lentivirus small hairpin RNA (shRNA) interference techniques were utilized to knock down the Rac3 gene. Gene and protein expression was quantified by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting. LC cell apoptosis was examined by annexin V-APC /propidium iodide staining. Results: Efficient silencing of Rac3 strongly inhibited A549 cell proliferation and colony formation ability, and significantly decreased tumor growth. Moreover, flow cytometry analysis showed that knockdown of Rac3 led to G2/M phase cell cycle arrest as well as an excess accumulation of cells in the G1 and S phase. Conclusions: Thus, functional analysis using shRNAs revealed a critical role for Rac3 in the tumor growth of LC cells. shRNA silencing of Rac3 could provide an effective strategy to treat LC." @default.
- W2128705539 created "2016-06-24" @default.
- W2128705539 creator A5021148568 @default.
- W2128705539 creator A5026891605 @default.
- W2128705539 creator A5036730966 @default.
- W2128705539 creator A5077215611 @default.
- W2128705539 creator A5084201050 @default.
- W2128705539 date "2015-04-14" @default.
- W2128705539 modified "2023-10-05" @default.
- W2128705539 title "Silencing of Rac3 Inhibits Proliferation and Induces Apoptosis of Human Lung Cancer Cells" @default.
- W2128705539 cites W1574913479 @default.
- W2128705539 cites W1990474105 @default.
- W2128705539 cites W2010669495 @default.
- W2128705539 cites W2019731805 @default.
- W2128705539 cites W2037174767 @default.
- W2128705539 cites W2040443947 @default.
- W2128705539 cites W2049405895 @default.
- W2128705539 cites W2106586483 @default.
- W2128705539 cites W2130326989 @default.
- W2128705539 cites W2132834292 @default.
- W2128705539 cites W2158731289 @default.
- W2128705539 cites W2169961966 @default.
- W2128705539 doi "https://doi.org/10.7314/apjcp.2015.16.7.3061" @default.
- W2128705539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25854406" @default.
- W2128705539 hasPublicationYear "2015" @default.
- W2128705539 type Work @default.
- W2128705539 sameAs 2128705539 @default.
- W2128705539 citedByCount "14" @default.
- W2128705539 countsByYear W21287055392016 @default.
- W2128705539 countsByYear W21287055392017 @default.
- W2128705539 countsByYear W21287055392018 @default.
- W2128705539 countsByYear W21287055392019 @default.
- W2128705539 countsByYear W21287055392020 @default.
- W2128705539 countsByYear W21287055392021 @default.
- W2128705539 countsByYear W21287055392022 @default.
- W2128705539 countsByYear W21287055392023 @default.
- W2128705539 crossrefType "journal-article" @default.
- W2128705539 hasAuthorship W2128705539A5021148568 @default.
- W2128705539 hasAuthorship W2128705539A5026891605 @default.
- W2128705539 hasAuthorship W2128705539A5036730966 @default.
- W2128705539 hasAuthorship W2128705539A5077215611 @default.
- W2128705539 hasAuthorship W2128705539A5084201050 @default.
- W2128705539 hasBestOaLocation W21287055391 @default.
- W2128705539 hasConcept C104317684 @default.
- W2128705539 hasConcept C119056186 @default.
- W2128705539 hasConcept C153911025 @default.
- W2128705539 hasConcept C166703698 @default.
- W2128705539 hasConcept C173396325 @default.
- W2128705539 hasConcept C185592680 @default.
- W2128705539 hasConcept C190232843 @default.
- W2128705539 hasConcept C190283241 @default.
- W2128705539 hasConcept C2775934118 @default.
- W2128705539 hasConcept C29537977 @default.
- W2128705539 hasConcept C31573885 @default.
- W2128705539 hasConcept C502942594 @default.
- W2128705539 hasConcept C55493867 @default.
- W2128705539 hasConcept C62112901 @default.
- W2128705539 hasConcept C67705224 @default.
- W2128705539 hasConcept C86803240 @default.
- W2128705539 hasConcept C95444343 @default.
- W2128705539 hasConceptScore W2128705539C104317684 @default.
- W2128705539 hasConceptScore W2128705539C119056186 @default.
- W2128705539 hasConceptScore W2128705539C153911025 @default.
- W2128705539 hasConceptScore W2128705539C166703698 @default.
- W2128705539 hasConceptScore W2128705539C173396325 @default.
- W2128705539 hasConceptScore W2128705539C185592680 @default.
- W2128705539 hasConceptScore W2128705539C190232843 @default.
- W2128705539 hasConceptScore W2128705539C190283241 @default.
- W2128705539 hasConceptScore W2128705539C2775934118 @default.
- W2128705539 hasConceptScore W2128705539C29537977 @default.
- W2128705539 hasConceptScore W2128705539C31573885 @default.
- W2128705539 hasConceptScore W2128705539C502942594 @default.
- W2128705539 hasConceptScore W2128705539C55493867 @default.
- W2128705539 hasConceptScore W2128705539C62112901 @default.
- W2128705539 hasConceptScore W2128705539C67705224 @default.
- W2128705539 hasConceptScore W2128705539C86803240 @default.
- W2128705539 hasConceptScore W2128705539C95444343 @default.
- W2128705539 hasIssue "7" @default.
- W2128705539 hasLocation W21287055391 @default.
- W2128705539 hasLocation W21287055392 @default.
- W2128705539 hasOpenAccess W2128705539 @default.
- W2128705539 hasPrimaryLocation W21287055391 @default.
- W2128705539 hasRelatedWork W2000149980 @default.
- W2128705539 hasRelatedWork W2039201715 @default.
- W2128705539 hasRelatedWork W2088835981 @default.
- W2128705539 hasRelatedWork W2162323474 @default.
- W2128705539 hasRelatedWork W2371961085 @default.
- W2128705539 hasRelatedWork W2377185255 @default.
- W2128705539 hasRelatedWork W2377702787 @default.
- W2128705539 hasRelatedWork W2413319726 @default.
- W2128705539 hasRelatedWork W2417676917 @default.
- W2128705539 hasRelatedWork W2749959219 @default.
- W2128705539 hasVolume "16" @default.
- W2128705539 isParatext "false" @default.
- W2128705539 isRetracted "false" @default.
- W2128705539 magId "2128705539" @default.
- W2128705539 workType "article" @default.