Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128709785> ?p ?o ?g. }
- W2128709785 endingPage "1659" @default.
- W2128709785 startingPage "1657" @default.
- W2128709785 abstract "Slowed relaxation in diabetic cardiomyopathy (CM) is partially related to diminished expression of the sarcoplasmic reticulum (SR) Ca2+-ATPase SERCA2a. To evaluate the impact of SERCA2a overexpression on SR Ca2+ handling in diabetic CM, we 1) generated transgenic rats harboring a human cytomegalovirus enhancer/chicken beta-actin promotor-controlled rat SERCA2 transgene (SERCA2-TGR), 2) characterized their SR phenotype, and 3) examined whether transgene expression may rescue SR Ca2+ transport in streptozotocin-induced diabetes. The transgene was expressed in all heart chambers. Compared to wild-type (WT) rats, a heterozygous line exhibited increased SERCA2 mRNA (1.5-fold), SERCA2 protein (+26%) and SR Ca2+ uptake (+37%). Phospholamban expression was not altered. In SERCA2-TGR, contraction amplitude (+48%) and rates of contraction (+34%) and relaxation (+35%) of isolated papillary muscles (PM) were increased (P2+ uptake and SERCA2 protein of SERCA2-TGR were 1.3-fold higher (P2+ uptake, accelerates relaxation and compensates, in part, for depressed Ca2+ uptake in diabetic CM. Therefore, SERCA2 expression might constitute an important therapeutic target to rescue cardiac SR Ca2+ handling in diabetes." @default.
- W2128709785 created "2016-06-24" @default.
- W2128709785 creator A5000750109 @default.
- W2128709785 creator A5028598965 @default.
- W2128709785 creator A5029880524 @default.
- W2128709785 creator A5030734608 @default.
- W2128709785 creator A5036210119 @default.
- W2128709785 creator A5060041272 @default.
- W2128709785 creator A5069245717 @default.
- W2128709785 creator A5072004025 @default.
- W2128709785 creator A5089159272 @default.
- W2128709785 creator A5091064248 @default.
- W2128709785 date "2002-08-21" @default.
- W2128709785 modified "2023-10-13" @default.
- W2128709785 title "Transgenic overexpression of the sarcoplasmic reticulum Ca <sup>2+</sup> ATPase improves reticular Ca <sup>2+</sup> handling in normal and diabetic rat hearts" @default.
- W2128709785 cites W1489130191 @default.
- W2128709785 cites W1967248278 @default.
- W2128709785 cites W1975080634 @default.
- W2128709785 cites W1986690550 @default.
- W2128709785 cites W1989463892 @default.
- W2128709785 cites W2025576575 @default.
- W2128709785 cites W2030760870 @default.
- W2128709785 cites W2031511749 @default.
- W2128709785 cites W2036708447 @default.
- W2128709785 cites W2037568202 @default.
- W2128709785 cites W2040487148 @default.
- W2128709785 cites W2045066333 @default.
- W2128709785 cites W2048303185 @default.
- W2128709785 cites W2048867275 @default.
- W2128709785 cites W2054961027 @default.
- W2128709785 cites W2058317457 @default.
- W2128709785 cites W2059769358 @default.
- W2128709785 cites W2069016264 @default.
- W2128709785 cites W2069509176 @default.
- W2128709785 cites W2072287097 @default.
- W2128709785 cites W2073891552 @default.
- W2128709785 cites W2074348670 @default.
- W2128709785 cites W2074481698 @default.
- W2128709785 cites W2074610906 @default.
- W2128709785 cites W2080240343 @default.
- W2128709785 cites W2097216911 @default.
- W2128709785 cites W2111716072 @default.
- W2128709785 cites W2115032762 @default.
- W2128709785 cites W2118237569 @default.
- W2128709785 cites W2135378280 @default.
- W2128709785 cites W2136378096 @default.
- W2128709785 cites W2139618637 @default.
- W2128709785 cites W2157581901 @default.
- W2128709785 cites W4245005236 @default.
- W2128709785 doi "https://doi.org/10.1096/fj.01-1019fje" @default.
- W2128709785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12206992" @default.
- W2128709785 hasPublicationYear "2002" @default.
- W2128709785 type Work @default.
- W2128709785 sameAs 2128709785 @default.
- W2128709785 citedByCount "89" @default.
- W2128709785 countsByYear W21287097852012 @default.
- W2128709785 countsByYear W21287097852013 @default.
- W2128709785 countsByYear W21287097852014 @default.
- W2128709785 countsByYear W21287097852015 @default.
- W2128709785 countsByYear W21287097852016 @default.
- W2128709785 countsByYear W21287097852017 @default.
- W2128709785 countsByYear W21287097852018 @default.
- W2128709785 countsByYear W21287097852019 @default.
- W2128709785 countsByYear W21287097852020 @default.
- W2128709785 countsByYear W21287097852021 @default.
- W2128709785 countsByYear W21287097852022 @default.
- W2128709785 countsByYear W21287097852023 @default.
- W2128709785 crossrefType "journal-article" @default.
- W2128709785 hasAuthorship W2128709785A5000750109 @default.
- W2128709785 hasAuthorship W2128709785A5028598965 @default.
- W2128709785 hasAuthorship W2128709785A5029880524 @default.
- W2128709785 hasAuthorship W2128709785A5030734608 @default.
- W2128709785 hasAuthorship W2128709785A5036210119 @default.
- W2128709785 hasAuthorship W2128709785A5060041272 @default.
- W2128709785 hasAuthorship W2128709785A5069245717 @default.
- W2128709785 hasAuthorship W2128709785A5072004025 @default.
- W2128709785 hasAuthorship W2128709785A5089159272 @default.
- W2128709785 hasAuthorship W2128709785A5091064248 @default.
- W2128709785 hasConcept C102230213 @default.
- W2128709785 hasConcept C104317684 @default.
- W2128709785 hasConcept C113217602 @default.
- W2128709785 hasConcept C126322002 @default.
- W2128709785 hasConcept C134018914 @default.
- W2128709785 hasConcept C141035611 @default.
- W2128709785 hasConcept C158617107 @default.
- W2128709785 hasConcept C163415756 @default.
- W2128709785 hasConcept C17137333 @default.
- W2128709785 hasConcept C181199279 @default.
- W2128709785 hasConcept C185592680 @default.
- W2128709785 hasConcept C23265538 @default.
- W2128709785 hasConcept C2775953344 @default.
- W2128709785 hasConcept C2776553924 @default.
- W2128709785 hasConcept C2778198053 @default.
- W2128709785 hasConcept C2778797674 @default.
- W2128709785 hasConcept C2779280383 @default.
- W2128709785 hasConcept C519063684 @default.
- W2128709785 hasConcept C55493867 @default.
- W2128709785 hasConcept C555293320 @default.