FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128717300> ?p ?o ?g. }

• W2128717300 endingPage "2679" @default.
• W2128717300 startingPage "2664" @default.
• W2128717300 abstract "Prostacyclin is increasingly implicated in re-endothelialization and angiogenesis but through largely unknown mechanisms. Herein the high-density lipoprotein (HDL) scavenger receptor class B, type 1 (SR-B1) adapter protein PDZ domain-containing protein 1 (PDZK1) was identified as an interactant of the human prostacyclin receptor (hIP) involving a Class I PDZ ligand at its carboxyl terminus and PDZ domains 1, 3, and 4 of PDZK1. Although the interaction is constitutive, it may be dynamically regulated following cicaprost activation of the hIP through a mechanism involving cAMP-dependent protein kinase (PK)A-phosphorylation of PDZK1 at Ser-505. Although PDZK1 did not increase overall levels of the hIP, it increased its functional expression at the cell surface, enhancing ligand binding and cicaprost-induced cAMP generation. Consistent with its role in re-endothelialization and angiogenesis, cicaprost activation of the hIP increased endothelial cell migration and tube formation/in vitro angiogenesis, effects completely abrogated by the specific IP antagonist RO1138452. Furthermore, similar to HDL/SR-B1, small interfering RNA (siRNA)-targeted disruption of PDZK1 abolished cicaprost-mediated endothelial responses but did not affect VEGF responses. Considering the essential role played by prostacyclin throughout the cardiovascular system, identification of PDZK1 as a functional interactant of the hIP sheds significant mechanistic insights into the protective roles of these key players, and potentially HDL/SR-B1, within the vascular endothelium." @default.
• W2128717300 created "2016-06-24" @default.
• W2128717300 creator A5011678403 @default.
• W2128717300 creator A5011706395 @default.
• W2128717300 creator A5074723905 @default.
• W2128717300 creator A5082891837 @default.
• W2128717300 date "2011-08-01" @default.
• W2128717300 modified "2023-09-30" @default.
• W2128717300 title "Interaction of the human prostacyclin receptor with the PDZ adapter protein PDZK1: role in endothelial cell migration and angiogenesis" @default.
• W2128717300 cites W1555143533 @default.
• W2128717300 cites W1666619344 @default.
• W2128717300 cites W1974668587 @default.
• W2128717300 cites W1978605506 @default.
• W2128717300 cites W1980035250 @default.
• W2128717300 cites W1985782184 @default.
• W2128717300 cites W1996895583 @default.
• W2128717300 cites W1997999470 @default.
• W2128717300 cites W2002829449 @default.
• W2128717300 cites W2005747738 @default.
• W2128717300 cites W2007010528 @default.
• W2128717300 cites W2007107936 @default.
• W2128717300 cites W2012801178 @default.
• W2128717300 cites W2015119995 @default.
• W2128717300 cites W2016586181 @default.
• W2128717300 cites W2019783790 @default.
• W2128717300 cites W2027085827 @default.
• W2128717300 cites W2032101997 @default.
• W2128717300 cites W2037592226 @default.
• W2128717300 cites W2040032984 @default.
• W2128717300 cites W2052552552 @default.
• W2128717300 cites W2055682511 @default.
• W2128717300 cites W2065989745 @default.
• W2128717300 cites W2068298188 @default.
• W2128717300 cites W2073024676 @default.
• W2128717300 cites W2074012627 @default.
• W2128717300 cites W2074570440 @default.
• W2128717300 cites W2078975633 @default.
• W2128717300 cites W2080441720 @default.
• W2128717300 cites W2081478756 @default.
• W2128717300 cites W2090110926 @default.
• W2128717300 cites W2090906537 @default.
• W2128717300 cites W2091845048 @default.
• W2128717300 cites W2092834198 @default.
• W2128717300 cites W2096776561 @default.
• W2128717300 cites W2097075934 @default.
• W2128717300 cites W2099918652 @default.
• W2128717300 cites W2101310235 @default.
• W2128717300 cites W2113551595 @default.
• W2128717300 cites W2124686173 @default.
• W2128717300 cites W2127325055 @default.
• W2128717300 cites W2128684716 @default.
• W2128717300 cites W2138571254 @default.
• W2128717300 cites W2141418895 @default.
• W2128717300 cites W2173707883 @default.
• W2128717300 cites W3206617012 @default.
• W2128717300 cites W4210623056 @default.
• W2128717300 cites W4247904703 @default.
• W2128717300 doi "https://doi.org/10.1091/mbc.e11-04-0374" @default.
• W2128717300 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3145543" @default.
• W2128717300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21653824" @default.
• W2128717300 hasPublicationYear "2011" @default.
• W2128717300 type Work @default.
• W2128717300 sameAs 2128717300 @default.
• W2128717300 citedByCount "26" @default.
• W2128717300 countsByYear W21287173002012 @default.
• W2128717300 countsByYear W21287173002013 @default.
• W2128717300 countsByYear W21287173002014 @default.
• W2128717300 countsByYear W21287173002015 @default.
• W2128717300 countsByYear W21287173002016 @default.
• W2128717300 countsByYear W21287173002017 @default.
• W2128717300 countsByYear W21287173002018 @default.
• W2128717300 countsByYear W21287173002020 @default.
• W2128717300 countsByYear W21287173002021 @default.
• W2128717300 countsByYear W21287173002023 @default.
• W2128717300 crossrefType "journal-article" @default.
• W2128717300 hasAuthorship W2128717300A5011678403 @default.
• W2128717300 hasAuthorship W2128717300A5011706395 @default.
• W2128717300 hasAuthorship W2128717300A5074723905 @default.
• W2128717300 hasAuthorship W2128717300A5082891837 @default.
• W2128717300 hasBestOaLocation W21287173002 @default.
• W2128717300 hasConcept C104317684 @default.
• W2128717300 hasConcept C11960822 @default.
• W2128717300 hasConcept C123012128 @default.
• W2128717300 hasConcept C134018914 @default.
• W2128717300 hasConcept C154428179 @default.
• W2128717300 hasConcept C170493617 @default.
• W2128717300 hasConcept C202751555 @default.
• W2128717300 hasConcept C22615655 @default.
• W2128717300 hasConcept C2780394083 @default.
• W2128717300 hasConcept C2781128415 @default.
• W2128717300 hasConcept C502942594 @default.
• W2128717300 hasConcept C54009773 @default.
• W2128717300 hasConcept C55493867 @default.
• W2128717300 hasConcept C86803240 @default.
• W2128717300 hasConcept C95444343 @default.
• W2128717300 hasConceptScore W2128717300C104317684 @default.
• W2128717300 hasConceptScore W2128717300C11960822 @default.
• W2128717300 hasConceptScore W2128717300C123012128 @default.

• next