Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128747747> ?p ?o ?g. }
- W2128747747 endingPage "2885" @default.
- W2128747747 startingPage "2879" @default.
- W2128747747 abstract "Using in vitro receptor autoradiography, the distributions of cholinergic muscarinic [3H-N-methyl scopolamine (NMS), 3H-pirenzepine (PZ), and 3H-oxotremorine-M (OXO-M)] and nicotinic [3H-acetylcholine (ACh)] receptors were mapped in the temporal cortices of rhesus monkeys (Macaca mulatta) ranging from 2-22 years of age. Although high-affinity 3H-PZ, low-affinity 3H-NMS binding (M1 sites) and high-affinity 3H-OXO- M, high-affinity 3H-NMS binding (M2 sites) occurred across all layers of the temporal neocortex, the laminar distribution of M1 and M2 receptor binding sites was different. M1 muscarinic receptor binding was concentrated in layers II and III, whereas M2 muscarinic receptor binding was greatest in layers IV and V. The concentration of both muscarinic (M1 and M2) and nicotinic receptor binding sites declined with increasing age, and decrements were uniform across all cortical layers. This investigation provides evidence for a decrease in cholinergic receptor binding with age in temporal cortices of rhesus monkeys. Moreover, these changes appear to precede previously reported age-associated memory deficits and neuropathological changes that occur in this species." @default.
- W2128747747 created "2016-06-24" @default.
- W2128747747 creator A5011369386 @default.
- W2128747747 creator A5017640771 @default.
- W2128747747 creator A5019444213 @default.
- W2128747747 creator A5043967898 @default.
- W2128747747 creator A5060095356 @default.
- W2128747747 date "1990-09-01" @default.
- W2128747747 modified "2023-10-11" @default.
- W2128747747 title "Laminar organization and age-related loss of cholinergic receptors in temporal neocortex of rhesus monkey" @default.
- W2128747747 cites W1855289338 @default.
- W2128747747 cites W1964179430 @default.
- W2128747747 cites W1968575522 @default.
- W2128747747 cites W1969441861 @default.
- W2128747747 cites W1977449284 @default.
- W2128747747 cites W1978745809 @default.
- W2128747747 cites W1980657066 @default.
- W2128747747 cites W1986076186 @default.
- W2128747747 cites W1986658952 @default.
- W2128747747 cites W1990981996 @default.
- W2128747747 cites W1994067502 @default.
- W2128747747 cites W1997120605 @default.
- W2128747747 cites W2004529130 @default.
- W2128747747 cites W2008913816 @default.
- W2128747747 cites W2025155885 @default.
- W2128747747 cites W2027680233 @default.
- W2128747747 cites W2030686709 @default.
- W2128747747 cites W2032546053 @default.
- W2128747747 cites W2033484484 @default.
- W2128747747 cites W2035970476 @default.
- W2128747747 cites W2036642860 @default.
- W2128747747 cites W2036877965 @default.
- W2128747747 cites W2037134597 @default.
- W2128747747 cites W2041341404 @default.
- W2128747747 cites W2042403615 @default.
- W2128747747 cites W2043604149 @default.
- W2128747747 cites W2050612571 @default.
- W2128747747 cites W2055708516 @default.
- W2128747747 cites W2056433957 @default.
- W2128747747 cites W2057213191 @default.
- W2128747747 cites W2059585135 @default.
- W2128747747 cites W2065393074 @default.
- W2128747747 cites W2065792838 @default.
- W2128747747 cites W2065825417 @default.
- W2128747747 cites W2071259192 @default.
- W2128747747 cites W2072717295 @default.
- W2128747747 cites W2073695258 @default.
- W2128747747 cites W2075057355 @default.
- W2128747747 cites W2077706021 @default.
- W2128747747 cites W2080781505 @default.
- W2128747747 cites W2084968056 @default.
- W2128747747 cites W2087883041 @default.
- W2128747747 cites W2093277140 @default.
- W2128747747 cites W2095103695 @default.
- W2128747747 cites W2111916837 @default.
- W2128747747 cites W2125887205 @default.
- W2128747747 cites W2137374430 @default.
- W2128747747 cites W2161685942 @default.
- W2128747747 cites W2170633533 @default.
- W2128747747 cites W2266713887 @default.
- W2128747747 cites W2327645632 @default.
- W2128747747 cites W2405172170 @default.
- W2128747747 cites W2431972938 @default.
- W2128747747 cites W2472124532 @default.
- W2128747747 cites W2568541548 @default.
- W2128747747 cites W2770348358 @default.
- W2128747747 doi "https://doi.org/10.1523/jneurosci.10-09-02879.1990" @default.
- W2128747747 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6570243" @default.
- W2128747747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2398366" @default.
- W2128747747 hasPublicationYear "1990" @default.
- W2128747747 type Work @default.
- W2128747747 sameAs 2128747747 @default.
- W2128747747 citedByCount "41" @default.
- W2128747747 countsByYear W21287477472013 @default.
- W2128747747 crossrefType "journal-article" @default.
- W2128747747 hasAuthorship W2128747747A5011369386 @default.
- W2128747747 hasAuthorship W2128747747A5017640771 @default.
- W2128747747 hasAuthorship W2128747747A5019444213 @default.
- W2128747747 hasAuthorship W2128747747A5043967898 @default.
- W2128747747 hasAuthorship W2128747747A5060095356 @default.
- W2128747747 hasBestOaLocation W21287477471 @default.
- W2128747747 hasConcept C126322002 @default.
- W2128747747 hasConcept C134018914 @default.
- W2128747747 hasConcept C169760540 @default.
- W2128747747 hasConcept C170493617 @default.
- W2128747747 hasConcept C185592680 @default.
- W2128747747 hasConcept C188987157 @default.
- W2128747747 hasConcept C207723603 @default.
- W2128747747 hasConcept C22885893 @default.
- W2128747747 hasConcept C2775910092 @default.
- W2128747747 hasConcept C2777222312 @default.
- W2128747747 hasConcept C2778616617 @default.
- W2128747747 hasConcept C2778824757 @default.
- W2128747747 hasConcept C33789571 @default.
- W2128747747 hasConcept C47488739 @default.
- W2128747747 hasConcept C64123433 @default.
- W2128747747 hasConcept C71924100 @default.
- W2128747747 hasConcept C80161118 @default.