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- W2128751535 abstract "Human papillomavirus (HPV) infection is involved in cervical lesion development. It interferes with host immune response and modifies the expression of human leukocyte antigen-G (HLA-G), a nonclassical HLA-I antigen with immune-inhibitory functions. We analyzed the frequencies of two HLA-G 3′ untranslated region polymorphisms (14 bp ins/del, +3142C>G), involved in HLA-G modulation, in 33 condyloma acuminatum, 14 low grade squamous intraepithelial lesion and 100 invasive cervical cancer (ICC) HPV infected patients. We showed the involvement of HLA-G polymorphisms in HPV infection and lesion development, and suggested that 14 bp del allele promotes high-risk HPV infection, with del/C haplotype associated with ICC development. On the basis of these evidences, HLA-G polymorphisms could represent a risk factor in HPV positive subjects." @default.
- W2128751535 created "2016-06-24" @default.
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- W2128751535 date "2014-01-07" @default.
- W2128751535 modified "2023-10-03" @default.
- W2128751535 title "Implication of HLA-G 3′ untranslated region polymorphisms in human papillomavirus infection" @default.
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- W2128751535 doi "https://doi.org/10.1111/tan.12281" @default.
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