FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128753989> ?p ?o ?g. }

• W2128753989 endingPage "181" @default.
• W2128753989 startingPage "173" @default.
• W2128753989 abstract "Ingestion of aflatoxin B1 is implicated in the high incidence of human liver cancers in several developing countries. An association has been detected between human exposure to aflatoxins, and mutations in the third base of codon 249 of the p53 gene in hepatomas. In vitro experiments using human cell line cells and aflatoxin B1 have demonstrated the induction of p53 mutations in codon 249 and adjacent codons. It was therefore of interest to see if this correlation between the in vivo and in vitro situations held for other species. The present study examined a rat liver-derived cell line, transformed in vitro with aflatoxin B1, for the presence of mutations associated with in vivo aflatoxin-induced hepatocarcinogenesis. In an in vivo rodent model systems using the aflatoxin B1-sensitive male F344 rat, previous studies have shown that hepatocarcinogenesis is accompanied by significant incidences of codon 12 mutations in K-ras and codon 13 mutations in N-ras genes, but in contrast to the human, apparently not by mutations in codon 243 of the p53 gene (which corresponds to codon 249 in the human gene). In contrast to the situation in humans, mutation in the third base of codon 243 in the rat would not result in any changes in amino acid sequence, but mutations in codon 250, as seen in in vitro human systems, would be expressed in the rat p53 protein. In the present study, an immortalised, non-transformed liver epithelial cell line derived from a male F344 rat was transformed in vitro by aflatoxin B1 as demonstrated by tumour formation in nude mice. The transformation was dependent on metabolic activation of the aflatoxin B1. Transfection of DNA, extracted from these tumours, into NIH 3T3 fibroblasts conferred a stable, malignant transforming capacity. However, no mutations in codon 12 of the K-ras or codon 13 of the N-ras genes were detected in any of these tumours. These results indicate that in vitro transformation does not necessarily involve the same mutations, as those observed in vivo. Also, no mutations in codon 243 or adjacent codons of the p53 gene, paralleling those observed in the human cell line treated with aflatoxin B1, were detected. The results serve to emphasise the in vivo and in vitro variation in the oncogene activation in the same target organ or cell lines derived from that organ, even when using a single carcinogen activated by a known metabolic pathway." @default.
• W2128753989 created "2016-06-24" @default.
• W2128753989 creator A5016356476 @default.
• W2128753989 creator A5024761896 @default.
• W2128753989 creator A5027810690 @default.
• W2128753989 creator A5030022307 @default.
• W2128753989 creator A5036749562 @default.
• W2128753989 creator A5069308603 @default.
• W2128753989 creator A5089997718 @default.
• W2128753989 date "1999-04-01" @default.
• W2128753989 modified "2023-10-18" @default.
• W2128753989 title "Mutations associated with in vivo aflatoxin B1-induced carcinogenesis need not be present in the in vitro transformations by this toxin" @default.
• W2128753989 cites W1501108160 @default.
• W2128753989 cites W1521489781 @default.
• W2128753989 cites W1659596920 @default.
• W2128753989 cites W1900380445 @default.
• W2128753989 cites W1973368924 @default.
• W2128753989 cites W1991876219 @default.
• W2128753989 cites W2009773967 @default.
• W2128753989 cites W2034349902 @default.
• W2128753989 cites W2035794058 @default.
• W2128753989 cites W2042316019 @default.
• W2128753989 cites W2049296953 @default.
• W2128753989 cites W2054532838 @default.
• W2128753989 cites W2055773431 @default.
• W2128753989 cites W2082170930 @default.
• W2128753989 cites W2091110129 @default.
• W2128753989 cites W2105061796 @default.
• W2128753989 cites W2107248281 @default.
• W2128753989 cites W2130744590 @default.
• W2128753989 cites W2140928877 @default.
• W2128753989 cites W2148150159 @default.
• W2128753989 cites W2405173083 @default.
• W2128753989 cites W3023525007 @default.
• W2128753989 doi "https://doi.org/10.1016/s0304-3835(98)00354-1" @default.
• W2128753989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10374839" @default.
• W2128753989 hasPublicationYear "1999" @default.
• W2128753989 type Work @default.
• W2128753989 sameAs 2128753989 @default.
• W2128753989 citedByCount "3" @default.
• W2128753989 countsByYear W21287539892014 @default.
• W2128753989 crossrefType "journal-article" @default.
• W2128753989 hasAuthorship W2128753989A5016356476 @default.
• W2128753989 hasAuthorship W2128753989A5024761896 @default.
• W2128753989 hasAuthorship W2128753989A5027810690 @default.
• W2128753989 hasAuthorship W2128753989A5030022307 @default.
• W2128753989 hasAuthorship W2128753989A5036749562 @default.
• W2128753989 hasAuthorship W2128753989A5069308603 @default.
• W2128753989 hasAuthorship W2128753989A5089997718 @default.
• W2128753989 hasConcept C104317684 @default.
• W2128753989 hasConcept C153911025 @default.
• W2128753989 hasConcept C202751555 @default.
• W2128753989 hasConcept C207001950 @default.
• W2128753989 hasConcept C31903555 @default.
• W2128753989 hasConcept C40758303 @default.
• W2128753989 hasConcept C501734568 @default.
• W2128753989 hasConcept C54355233 @default.
• W2128753989 hasConcept C555283112 @default.
• W2128753989 hasConcept C86803240 @default.
• W2128753989 hasConceptScore W2128753989C104317684 @default.
• W2128753989 hasConceptScore W2128753989C153911025 @default.
• W2128753989 hasConceptScore W2128753989C202751555 @default.
• W2128753989 hasConceptScore W2128753989C207001950 @default.
• W2128753989 hasConceptScore W2128753989C31903555 @default.
• W2128753989 hasConceptScore W2128753989C40758303 @default.
• W2128753989 hasConceptScore W2128753989C501734568 @default.
• W2128753989 hasConceptScore W2128753989C54355233 @default.
• W2128753989 hasConceptScore W2128753989C555283112 @default.
• W2128753989 hasConceptScore W2128753989C86803240 @default.
• W2128753989 hasIssue "2" @default.
• W2128753989 hasLocation W21287539891 @default.
• W2128753989 hasLocation W21287539892 @default.
• W2128753989 hasOpenAccess W2128753989 @default.
• W2128753989 hasPrimaryLocation W21287539891 @default.
• W2128753989 hasRelatedWork W1996555041 @default.
• W2128753989 hasRelatedWork W2005867936 @default.
• W2128753989 hasRelatedWork W2047282247 @default.
• W2128753989 hasRelatedWork W2053473070 @default.
• W2128753989 hasRelatedWork W2055778129 @default.
• W2128753989 hasRelatedWork W2060958215 @default.
• W2128753989 hasRelatedWork W2100964397 @default.
• W2128753989 hasRelatedWork W2102375460 @default.
• W2128753989 hasRelatedWork W2346693789 @default.
• W2128753989 hasRelatedWork W4239604825 @default.
• W2128753989 hasVolume "137" @default.
• W2128753989 isParatext "false" @default.
• W2128753989 isRetracted "false" @default.
• W2128753989 magId "2128753989" @default.
• W2128753989 workType "article" @default.