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- W2128759938 abstract "Abstract Background: Previous studies on the association between one-carbon dietary factors and gastric cancer risk have been inconsistent. Methods: We investigated this association using data from a prospective study, the Shanghai Women's Health Study (1997–2010), including 323 distal gastric cancer cases identified from 73,009 Chinese women. HRs and 95% confidence intervals (CI) were estimated using Cox proportional hazard regression after adjusting for confounders. Results: Overall, no statistically significant association of gastric cancer was observed with dietary intake of folate, methionine, or B vitamins. However, when stratified by menopausal status, higher intake of riboflavin was associated with decreased gastric cancer risk in premenopausal women with HR of 0.35 (95% CI, 0.17–0.73), 0.48 (0.24–0.97), 0.28 (0.12–0.65), and 0.23 (0.07–0.91), respectively, for the quintiles 2 to 5 intake groups compared with the lowest quintile intake (P for trend = 0.02). Among premenopausal women, highest intake of folate was associated with increased gastric cancer risk (HR, 2.62; 95% CI, 1.04–6.59). There were no statistically significant associations observed among postmenopausal women. Conclusions: These results suggest that dietary factors involved in one-carbon metabolism are associated with gastric cancer risk among premenopausal women. Impact: Riboflavin may be a protective factor and folate may be a risk factor for premenopausal gastric cancer. Cancer Epidemiol Biomarkers Prev; 23(7); 1374–82. ©2014 AACR." @default.
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- W2128759938 date "2014-07-01" @default.
- W2128759938 modified "2023-09-26" @default.
- W2128759938 title "One-Carbon Metabolism Dietary Factors and Distal Gastric Cancer Risk in Chinese Women" @default.
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- W2128759938 doi "https://doi.org/10.1158/1055-9965.epi-14-0038" @default.
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