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• W2128763987 abstract "The afferent limb of the intestinal immune system is represented by the gut-associated lymphoid tissue, in which antigenic material, including complete bacteria, is taken up from the lumen by specialized epithelial cells (M cells). Because the adherence of micro-organisms to epithelial can be mediated by lectin-sugar bindings, the glycoconjugates of the surfaces of M cells and enterocytes were compared.A set of 28 lectins and corresponding sugars was used for light and electron microscopy of fixed and unfixed sections. M cells were identified by anti-vimentin antibodies.M cells of the cecal lymphoid patches selectively bound lectins specific for fucose or N-acetylgalactosamine. The labeled glycoconjugates were located in the apical membrane and in the membrane of vesicles in the apical cytoplasm. Enterocytes were selectively labeled by galactose-specific lectins. In contrast, the lectin-reactivity of M cells and enterocytes did not differ in the jejunal Peyer's patches.The results suggest that there may be selectivity mediated by glycoconjugates in the uptake of antigenic material by cecal M cells but not by jejunal M cells." @default.
• W2128763987 created "2016-06-24" @default.
• W2128763987 creator A5003321631 @default.
• W2128763987 creator A5082776300 @default.
• W2128763987 date "1993-11-01" @default.
• W2128763987 modified "2023-09-23" @default.
• W2128763987 title "Differential binding of lectins to M cells and enterocytes in the rabbit cecum" @default.
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• W2128763987 doi "https://doi.org/10.1016/0016-5085(93)90139-4" @default.
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