FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128766230> ?p ?o ?g. }

• W2128766230 endingPage "397" @default.
• W2128766230 startingPage "391" @default.
• W2128766230 abstract "The thyromimetic compound SK&F L-94901 shows more potent thyromimetic activity in the liver than in the pituitary gland or heart when administered to rats. The mechanisms of liver-selectivity of SK&F L-94901 were examined using cultured rat hepatoma cells (dRLH-84) and rat pituitary tumor cells (GH3), both of which showed saturable cellular uptake of tri-iodothyronine (T(3)). When isolated nuclei with partial disruption of the outer nuclear membrane were used, SK L-94901 competed for [(125)I]T(3) binding to nuclear receptors almost equally in dRLH-84 and GH3 cells. SK L-94901 also did not discriminate thyroid hormone receptors (TR) alpha1 and beta1 in terms of binding affinity and activation of the thyroid hormone responsive element. In intact cells, however, SK L-94901 was a more potent inhibitor of nuclear [(125)I]T(3) binding in dRLH-84 cells than in GH3 cells at an early phase of the nuclear uptake process and after binding equilibrium. These data suggest that SK L-94901 is more effectively transported to nuclear TRs in hepatic cells than in pituitary cells and therefore shows liver-selective thyromimetic activity. In conclusion, SK L-94901 discriminates hepatic cells and pituitary cells at the nuclear transport process. The cellular transporters responsible for this discrimination were not evident." @default.
• W2128766230 created "2016-06-24" @default.
• W2128766230 creator A5004209628 @default.
• W2128766230 creator A5009571083 @default.
• W2128766230 creator A5035516277 @default.
• W2128766230 creator A5042895299 @default.
• W2128766230 creator A5050612602 @default.
• W2128766230 creator A5051634071 @default.
• W2128766230 creator A5052307214 @default.
• W2128766230 creator A5063714633 @default.
• W2128766230 creator A5068069908 @default.
• W2128766230 creator A5091214569 @default.
• W2128766230 date "2000-05-01" @default.
• W2128766230 modified "2023-10-03" @default.
• W2128766230 title "Mechanism of liver-selective thyromimetic activity of SK&F L-94901: evidence for the presence of a cell-type-specific nuclear iodothyronine transport process" @default.
• W2128766230 cites W1593924964 @default.
• W2128766230 cites W1595234089 @default.
• W2128766230 cites W1597733532 @default.
• W2128766230 cites W1906197854 @default.
• W2128766230 cites W1963066038 @default.
• W2128766230 cites W1975691241 @default.
• W2128766230 cites W1982616132 @default.
• W2128766230 cites W1992032967 @default.
• W2128766230 cites W1994763926 @default.
• W2128766230 cites W1997873916 @default.
• W2128766230 cites W2003002984 @default.
• W2128766230 cites W2010817865 @default.
• W2128766230 cites W2019705832 @default.
• W2128766230 cites W2022022576 @default.
• W2128766230 cites W2058663633 @default.
• W2128766230 cites W2064007418 @default.
• W2128766230 cites W2071013566 @default.
• W2128766230 cites W2077848026 @default.
• W2128766230 cites W2080077090 @default.
• W2128766230 cites W2087522520 @default.
• W2128766230 cites W2089264059 @default.
• W2128766230 cites W2409796402 @default.
• W2128766230 cites W2426734962 @default.
• W2128766230 cites W3157659537 @default.
• W2128766230 doi "https://doi.org/10.1677/joe.0.1650391" @default.
• W2128766230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10810303" @default.
• W2128766230 hasPublicationYear "2000" @default.
• W2128766230 type Work @default.
• W2128766230 sameAs 2128766230 @default.
• W2128766230 citedByCount "21" @default.
• W2128766230 countsByYear W21287662302013 @default.
• W2128766230 countsByYear W21287662302014 @default.
• W2128766230 crossrefType "journal-article" @default.
• W2128766230 hasAuthorship W2128766230A5004209628 @default.
• W2128766230 hasAuthorship W2128766230A5009571083 @default.
• W2128766230 hasAuthorship W2128766230A5035516277 @default.
• W2128766230 hasAuthorship W2128766230A5042895299 @default.
• W2128766230 hasAuthorship W2128766230A5050612602 @default.
• W2128766230 hasAuthorship W2128766230A5051634071 @default.
• W2128766230 hasAuthorship W2128766230A5052307214 @default.
• W2128766230 hasAuthorship W2128766230A5063714633 @default.
• W2128766230 hasAuthorship W2128766230A5068069908 @default.
• W2128766230 hasAuthorship W2128766230A5091214569 @default.
• W2128766230 hasBestOaLocation W21287662301 @default.
• W2128766230 hasConcept C104317684 @default.
• W2128766230 hasConcept C126322002 @default.
• W2128766230 hasConcept C134018914 @default.
• W2128766230 hasConcept C1491633281 @default.
• W2128766230 hasConcept C170493617 @default.
• W2128766230 hasConcept C202751555 @default.
• W2128766230 hasConcept C2777658017 @default.
• W2128766230 hasConcept C55493867 @default.
• W2128766230 hasConcept C63932345 @default.
• W2128766230 hasConcept C71315377 @default.
• W2128766230 hasConcept C71924100 @default.
• W2128766230 hasConcept C86339819 @default.
• W2128766230 hasConcept C86803240 @default.
• W2128766230 hasConceptScore W2128766230C104317684 @default.
• W2128766230 hasConceptScore W2128766230C126322002 @default.
• W2128766230 hasConceptScore W2128766230C134018914 @default.
• W2128766230 hasConceptScore W2128766230C1491633281 @default.
• W2128766230 hasConceptScore W2128766230C170493617 @default.
• W2128766230 hasConceptScore W2128766230C202751555 @default.
• W2128766230 hasConceptScore W2128766230C2777658017 @default.
• W2128766230 hasConceptScore W2128766230C55493867 @default.
• W2128766230 hasConceptScore W2128766230C63932345 @default.
• W2128766230 hasConceptScore W2128766230C71315377 @default.
• W2128766230 hasConceptScore W2128766230C71924100 @default.
• W2128766230 hasConceptScore W2128766230C86339819 @default.
• W2128766230 hasConceptScore W2128766230C86803240 @default.
• W2128766230 hasIssue "2" @default.
• W2128766230 hasLocation W21287662301 @default.
• W2128766230 hasLocation W21287662302 @default.
• W2128766230 hasOpenAccess W2128766230 @default.
• W2128766230 hasPrimaryLocation W21287662301 @default.
• W2128766230 hasRelatedWork W1996846474 @default.
• W2128766230 hasRelatedWork W1997759048 @default.
• W2128766230 hasRelatedWork W2027210979 @default.
• W2128766230 hasRelatedWork W2027938488 @default.
• W2128766230 hasRelatedWork W2033472167 @default.
• W2128766230 hasRelatedWork W2034583712 @default.
• W2128766230 hasRelatedWork W2063619316 @default.
• W2128766230 hasRelatedWork W2069420617 @default.

• next