FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128776304> ?p ?o ?g. }

• W2128776304 endingPage "850" @default.
• W2128776304 startingPage "841" @default.
• W2128776304 abstract "Members of the Bcl-2 family serve as central checkpoints for cell death regulation, and overexpression of Bcl-2 is known to inhibit apoptosis in many cell types. To determine whether targeted expression of Bcl-2 could be used to protect female germ cells from apoptosis, we generated transgenic mice expressing fully functional human Bcl-2 protein only in oocytes. Transgenic mice were produced using a previously characterized 480-bp fragment of the mouse zona pellucida protein-3 (ZP3) gene 5'-flanking region to direct oocyte-specific expression of a human bcl-2 complementary DNA. Immunohistochemical analyses using a human Bcl-2-specific antibody showed that transgene expression was restricted to growing oocytes and was not observed in the surrounding ovarian somatic cells or in any other nonovarian tissues. Histomorphometric analyses revealed that ovaries collected from transgenic female mice possessed significantly fewer atretic small preantral follicles compared with wild-type sisters, resulting in a larger population of healthy maturing follicles per ovary. However, the number of oocytes ovulated in response to exogenous gonadotropin priming and the number of pups per litter were not significantly different among wild-type vs. transgenic female mice. Nonetheless, oocytes obtained from transgenic mice and cultured in vitro were found to be resistant to spontaneous and anticancer drug-induced apoptosis. We conclude that targeted expression of Bcl-2 only in oocytes can be achieved as a means to convey resistance of the female germ line to naturally occurring and chemotherapy-induced apoptosis." @default.
• W2128776304 created "2016-06-24" @default.
• W2128776304 creator A5006501583 @default.
• W2128776304 creator A5015310581 @default.
• W2128776304 creator A5022343830 @default.
• W2128776304 creator A5025704557 @default.
• W2128776304 creator A5027818367 @default.
• W2128776304 date "1999-06-01" @default.
• W2128776304 modified "2023-10-17" @default.
• W2128776304 title "Targeted Expression of Bcl-2 in Mouse Oocytes Inhibits Ovarian Follicle Atresia and Prevents Spontaneous and Chemotherapy-Induced Oocyte Apoptosis In Vitro" @default.
• W2128776304 cites W1577859676 @default.
• W2128776304 cites W1774474273 @default.
• W2128776304 cites W1964617786 @default.
• W2128776304 cites W1981531462 @default.
• W2128776304 cites W1981717431 @default.
• W2128776304 cites W1992915927 @default.
• W2128776304 cites W2008597649 @default.
• W2128776304 cites W2014669590 @default.
• W2128776304 cites W2016774048 @default.
• W2128776304 cites W2025233095 @default.
• W2128776304 cites W2055682446 @default.
• W2128776304 cites W2060937867 @default.
• W2128776304 cites W2061401277 @default.
• W2128776304 cites W2075029530 @default.
• W2128776304 cites W2080700340 @default.
• W2128776304 cites W2086085711 @default.
• W2128776304 cites W2086518534 @default.
• W2128776304 cites W2089826191 @default.
• W2128776304 cites W2097270150 @default.
• W2128776304 cites W2124221273 @default.
• W2128776304 cites W2125088406 @default.
• W2128776304 cites W2132177748 @default.
• W2128776304 cites W2141887625 @default.
• W2128776304 cites W2142617031 @default.
• W2128776304 cites W2144406783 @default.
• W2128776304 cites W2145596465 @default.
• W2128776304 cites W2150839256 @default.
• W2128776304 cites W2156483686 @default.
• W2128776304 cites W2161387337 @default.
• W2128776304 cites W2182095480 @default.
• W2128776304 cites W2331073645 @default.
• W2128776304 cites W71160006 @default.
• W2128776304 doi "https://doi.org/10.1210/mend.13.6.0306" @default.
• W2128776304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10379884" @default.
• W2128776304 hasPublicationYear "1999" @default.
• W2128776304 type Work @default.
• W2128776304 sameAs 2128776304 @default.
• W2128776304 citedByCount "130" @default.
• W2128776304 countsByYear W21287763042012 @default.
• W2128776304 countsByYear W21287763042013 @default.
• W2128776304 countsByYear W21287763042014 @default.
• W2128776304 countsByYear W21287763042015 @default.
• W2128776304 countsByYear W21287763042016 @default.
• W2128776304 countsByYear W21287763042017 @default.
• W2128776304 countsByYear W21287763042018 @default.
• W2128776304 countsByYear W21287763042019 @default.
• W2128776304 countsByYear W21287763042020 @default.
• W2128776304 countsByYear W21287763042021 @default.
• W2128776304 countsByYear W21287763042022 @default.
• W2128776304 countsByYear W21287763042023 @default.
• W2128776304 crossrefType "journal-article" @default.
• W2128776304 hasAuthorship W2128776304A5006501583 @default.
• W2128776304 hasAuthorship W2128776304A5015310581 @default.
• W2128776304 hasAuthorship W2128776304A5022343830 @default.
• W2128776304 hasAuthorship W2128776304A5025704557 @default.
• W2128776304 hasAuthorship W2128776304A5027818367 @default.
• W2128776304 hasBestOaLocation W21287763041 @default.
• W2128776304 hasConcept C102230213 @default.
• W2128776304 hasConcept C104317684 @default.
• W2128776304 hasConcept C126322002 @default.
• W2128776304 hasConcept C134018914 @default.
• W2128776304 hasConcept C134305767 @default.
• W2128776304 hasConcept C141035611 @default.
• W2128776304 hasConcept C153911025 @default.
• W2128776304 hasConcept C16685009 @default.
• W2128776304 hasConcept C190283241 @default.
• W2128776304 hasConcept C196843134 @default.
• W2128776304 hasConcept C2776010925 @default.
• W2128776304 hasConcept C2776690073 @default.
• W2128776304 hasConcept C2778324911 @default.
• W2128776304 hasConcept C2779122487 @default.
• W2128776304 hasConcept C2780536345 @default.
• W2128776304 hasConcept C502942594 @default.
• W2128776304 hasConcept C54355233 @default.
• W2128776304 hasConcept C5512455 @default.
• W2128776304 hasConcept C71924100 @default.
• W2128776304 hasConcept C86803240 @default.
• W2128776304 hasConcept C87073359 @default.
• W2128776304 hasConcept C95444343 @default.
• W2128776304 hasConceptScore W2128776304C102230213 @default.
• W2128776304 hasConceptScore W2128776304C104317684 @default.
• W2128776304 hasConceptScore W2128776304C126322002 @default.
• W2128776304 hasConceptScore W2128776304C134018914 @default.
• W2128776304 hasConceptScore W2128776304C134305767 @default.
• W2128776304 hasConceptScore W2128776304C141035611 @default.
• W2128776304 hasConceptScore W2128776304C153911025 @default.
• W2128776304 hasConceptScore W2128776304C16685009 @default.
• W2128776304 hasConceptScore W2128776304C190283241 @default.

• next