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- W2128778852 abstract "THE COST OF RESTENOSIS after percutaneous coronary interventions and revascularization procedures is estimated to exceed $2 billion annually. 1 Topol EJ Califf RM Weisman HF et al. Randomised trial of coronary intervention with antibody against platelet IIb/IIIa integrin for reduction of clinical restenosis: Results at six months. Lancet. 1994; 343: 881-886 Abstract PubMed Scopus (826) Google Scholar Consequently, there is great interest in the development of adjuvant anticoagulant drugs and antiplatelet agents. Platelet glycoprotein (GP) IIb/IIIa receptor antagonists have shown great promise as adjunctive therapy in patients undergoing percutaneous coronary interventions. To date, more than 40,000 patients with ischemic heart disease have been treated with platelet GP IIb/IIIa antagonists. 2 Topol EJ Byzova TV Plow EF Platelet GP IIb/IIIa blockers. Lancet. 1999; 353: 227-231 Abstract Full Text Full Text PDF PubMed Scopus (509) Google Scholar Some of these patients subsequently required urgent coronary artery bypass graft (CABG) surgery with substantial risks for adverse outcomes related to impaired hemostasis. Understanding the mechanisms of action, drug interactions, and adverse side effects of these novel platelet antagonists can lead to strategies to decrease the potential for adverse perioperative outcomes after the administration of GP IIb/IIIa antagonists." @default.
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- W2128778852 date "2001-04-01" @default.
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- W2128778852 title "Platelet glycoprotein IIb/IIIa antagonists: Perioperative implications" @default.
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- W2128778852 doi "https://doi.org/10.1053/jcan.2001.21991" @default.
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