FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128786052> ?p ?o ?g. }

• W2128786052 endingPage "L770" @default.
• W2128786052 startingPage "L761" @default.
• W2128786052 abstract "The mechanisms by which respiratory syncytial virus (RSV) infection causes airway hyperresponsiveness (AHR) are not fully established. We hypothesized that RSV infection may alter the expression of airway sensory neuropeptides, thereby contributing to the development of altered airway function. BALB/c mice were infected with RSV followed by assessment of airway function, inflammation, and sensory neuropeptide expression. After RSV infection, mice developed significant airway inflammation associated with increased airway resistance to inhaled methacholine and increased tracheal smooth muscle responsiveness to electrical field stimulation. In these animals, substance P expression was markedly increased, whereas calcitonin gene-related peptide (CGRP) expression was decreased in airway tissue. Prophylactic treatment with Sendide, a highly selective antagonist of the neurokinin-1 receptor, or CGRP, but not the CGRP antagonist CGRP(8-37), inhibited the development of airway inflammation and AHR in RSV-infected animals. Therapeutic treatment with CGRP, but not CGRP(8-37) or Sendide, abolished AHR in RSV-infected animals despite increased substance P levels and previously established airway inflammation. These data suggest that RSV-induced airway dysfunction is, at least in part, due to an imbalance in sensory neuropeptide expression in the airways. Restoration of this balance may be beneficial for the treatment of RSV-mediated airway dysfunction." @default.
• W2128786052 created "2016-06-24" @default.
• W2128786052 creator A5011430982 @default.
• W2128786052 creator A5023960478 @default.
• W2128786052 creator A5025400440 @default.
• W2128786052 creator A5034422981 @default.
• W2128786052 creator A5038030291 @default.
• W2128786052 creator A5038777816 @default.
• W2128786052 creator A5040230220 @default.
• W2128786052 creator A5043918320 @default.
• W2128786052 creator A5052063428 @default.
• W2128786052 creator A5061643459 @default.
• W2128786052 creator A5089870533 @default.
• W2128786052 creator A5090296046 @default.
• W2128786052 creator A5091555235 @default.
• W2128786052 date "2005-04-01" @default.
• W2128786052 modified "2023-09-26" @default.
• W2128786052 title "Alteration of airway neuropeptide expression and development of airway hyperresponsiveness following respiratory syncytial virus infection" @default.
• W2128786052 cites W1498564737 @default.
• W2128786052 cites W1536099793 @default.
• W2128786052 cites W1964251697 @default.
• W2128786052 cites W1967761449 @default.
• W2128786052 cites W1969962622 @default.
• W2128786052 cites W1971057004 @default.
• W2128786052 cites W1973297528 @default.
• W2128786052 cites W1974727511 @default.
• W2128786052 cites W1983164777 @default.
• W2128786052 cites W1984634924 @default.
• W2128786052 cites W1998655325 @default.
• W2128786052 cites W1999822124 @default.
• W2128786052 cites W2004122848 @default.
• W2128786052 cites W2009443799 @default.
• W2128786052 cites W2012272559 @default.
• W2128786052 cites W2016919586 @default.
• W2128786052 cites W2019677652 @default.
• W2128786052 cites W2022727369 @default.
• W2128786052 cites W2023347221 @default.
• W2128786052 cites W2026403230 @default.
• W2128786052 cites W2036440284 @default.
• W2128786052 cites W2039428280 @default.
• W2128786052 cites W2044047233 @default.
• W2128786052 cites W2063435515 @default.
• W2128786052 cites W2066113222 @default.
• W2128786052 cites W2071502595 @default.
• W2128786052 cites W2080731454 @default.
• W2128786052 cites W2087354425 @default.
• W2128786052 cites W2089649548 @default.
• W2128786052 cites W2093566215 @default.
• W2128786052 cites W2106134409 @default.
• W2128786052 cites W2106228120 @default.
• W2128786052 cites W2124714277 @default.
• W2128786052 cites W2136444634 @default.
• W2128786052 cites W2145783587 @default.
• W2128786052 cites W2152848856 @default.
• W2128786052 cites W2158789561 @default.
• W2128786052 cites W2164212335 @default.
• W2128786052 cites W2400280020 @default.
• W2128786052 cites W2423562704 @default.
• W2128786052 cites W963764839 @default.
• W2128786052 doi "https://doi.org/10.1152/ajplung.00143.2004" @default.
• W2128786052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15608150" @default.
• W2128786052 hasPublicationYear "2005" @default.
• W2128786052 type Work @default.
• W2128786052 sameAs 2128786052 @default.
• W2128786052 citedByCount "51" @default.
• W2128786052 countsByYear W21287860522012 @default.
• W2128786052 countsByYear W21287860522013 @default.
• W2128786052 countsByYear W21287860522015 @default.
• W2128786052 countsByYear W21287860522016 @default.
• W2128786052 countsByYear W21287860522017 @default.
• W2128786052 countsByYear W21287860522018 @default.
• W2128786052 countsByYear W21287860522020 @default.
• W2128786052 countsByYear W21287860522021 @default.
• W2128786052 countsByYear W21287860522022 @default.
• W2128786052 countsByYear W21287860522023 @default.
• W2128786052 crossrefType "journal-article" @default.
• W2128786052 hasAuthorship W2128786052A5011430982 @default.
• W2128786052 hasAuthorship W2128786052A5023960478 @default.
• W2128786052 hasAuthorship W2128786052A5025400440 @default.
• W2128786052 hasAuthorship W2128786052A5034422981 @default.
• W2128786052 hasAuthorship W2128786052A5038030291 @default.
• W2128786052 hasAuthorship W2128786052A5038777816 @default.
• W2128786052 hasAuthorship W2128786052A5040230220 @default.
• W2128786052 hasAuthorship W2128786052A5043918320 @default.
• W2128786052 hasAuthorship W2128786052A5052063428 @default.
• W2128786052 hasAuthorship W2128786052A5061643459 @default.
• W2128786052 hasAuthorship W2128786052A5089870533 @default.
• W2128786052 hasAuthorship W2128786052A5090296046 @default.
• W2128786052 hasAuthorship W2128786052A5091555235 @default.
• W2128786052 hasConcept C105922876 @default.
• W2128786052 hasConcept C118303440 @default.
• W2128786052 hasConcept C126322002 @default.
• W2128786052 hasConcept C137130169 @default.
• W2128786052 hasConcept C163170386 @default.
• W2128786052 hasConcept C170493617 @default.
• W2128786052 hasConcept C203014093 @default.
• W2128786052 hasConcept C2776089194 @default.
• W2128786052 hasConcept C2776178081 @default.

• next