FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128786502> ?p ?o ?g. }

• W2128786502 endingPage "E1236" @default.
• W2128786502 startingPage "E1228" @default.
• W2128786502 abstract "Kisspeptins stimulate GnRH and thus gonadotropin secretion. Kisspeptin-10 is the minimal kisspeptin sequence with full intrinsic bioactivity, but it has not been studied in man. We investigated our hypothesis that kisspeptin-10 increases GnRH and thus LH pulse frequency. The dose response of kisspeptin-10 was investigated by administering iv bolus doses (0.01–3.0 μg/kg) and vehicle to healthy men. Effects on LH pulse frequency and size were determined by deconvolution analysis during infusion of kisspeptin-10 for up to 22.5 h. Intravenous bolus kisspeptin-10 resulted in a rapid and dose-dependent rise in serum LH concentration, with maximal stimulation at 1 μg/kg (4.1 ± 0.4 to 12.4 ± 1.7 IU/liter at 30 min, P < 0.001, n = 6). Administration of 3 μg/kg elicited a reduced response vs. 1 μg/kg (P < 0.05). Infusion of kisspeptin-10 at 4 μg/kg · h for 22.5 h elicited an increase in LH from a mean of 5.4 ± 0.7 to 20.8 ± 4.9 IU/liter (n = 4; P < 0.05) and serum testosterone increased from 16.6 ± 2.4 to 24.0 ± 2.5 nmol/liter (P < 0.001). LH pulses were obscured at this high rate of secretion, but a lower dose infusion of kisspeptin-10 (1.5 μg/kg · h) increased mean LH from 5.2 ± 0.8 to 14.1 ± 1.7 IU/liter (n = 4; P < 0.01) and increased LH pulse frequency from 0.7 ± 0.1 to 1.0 ± 0.2 pulses/h (P < 0.05) and secretory burst mass from 3.9 ± 0.4 to 12.8 ± 2.6 IU/liter (P < 0.05). Kisspeptin-10 boluses potently evoke LH secretion in men, and continuous infusion increases testosterone, LH pulse frequency, and pulse size. Kisspeptin analogues have therapeutic potential as regulators of LH and thus testosterone secretion." @default.
• W2128786502 created "2016-06-24" @default.
• W2128786502 creator A5003698342 @default.
• W2128786502 creator A5028516152 @default.
• W2128786502 creator A5028954901 @default.
• W2128786502 creator A5034066967 @default.
• W2128786502 creator A5049377842 @default.
• W2128786502 creator A5073165630 @default.
• W2128786502 creator A5074801878 @default.
• W2128786502 date "2011-08-01" @default.
• W2128786502 modified "2023-09-27" @default.
• W2128786502 title "Kisspeptin-10 Is a Potent Stimulator of LH and Increases Pulse Frequency in Men" @default.
• W2128786502 cites W1975310201 @default.
• W2128786502 cites W1977013546 @default.
• W2128786502 cites W1982432756 @default.
• W2128786502 cites W1989716417 @default.
• W2128786502 cites W2003492152 @default.
• W2128786502 cites W2004029564 @default.
• W2128786502 cites W2012579732 @default.
• W2128786502 cites W2013104189 @default.
• W2128786502 cites W2019435910 @default.
• W2128786502 cites W2028777780 @default.
• W2128786502 cites W2029845917 @default.
• W2128786502 cites W2032263844 @default.
• W2128786502 cites W2032534668 @default.
• W2128786502 cites W2033152098 @default.
• W2128786502 cites W2041190197 @default.
• W2128786502 cites W2045555035 @default.
• W2128786502 cites W2048872158 @default.
• W2128786502 cites W2051396500 @default.
• W2128786502 cites W2055660125 @default.
• W2128786502 cites W2058657335 @default.
• W2128786502 cites W2059430403 @default.
• W2128786502 cites W2063154584 @default.
• W2128786502 cites W2067130406 @default.
• W2128786502 cites W2070193527 @default.
• W2128786502 cites W2073220855 @default.
• W2128786502 cites W2077412978 @default.
• W2128786502 cites W2090020050 @default.
• W2128786502 cites W2092206211 @default.
• W2128786502 cites W2098329444 @default.
• W2128786502 cites W2105534609 @default.
• W2128786502 cites W2107920211 @default.
• W2128786502 cites W2111338104 @default.
• W2128786502 cites W2111824942 @default.
• W2128786502 cites W2120568375 @default.
• W2128786502 cites W2133914461 @default.
• W2128786502 cites W2138943538 @default.
• W2128786502 cites W2141582604 @default.
• W2128786502 cites W2142686356 @default.
• W2128786502 cites W2143506157 @default.
• W2128786502 cites W2144716768 @default.
• W2128786502 cites W2155530831 @default.
• W2128786502 cites W2158795213 @default.
• W2128786502 cites W2160104144 @default.
• W2128786502 cites W2171193387 @default.
• W2128786502 doi "https://doi.org/10.1210/jc.2011-0089" @default.
• W2128786502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3380939" @default.
• W2128786502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21632807" @default.
• W2128786502 hasPublicationYear "2011" @default.
• W2128786502 type Work @default.
• W2128786502 sameAs 2128786502 @default.
• W2128786502 citedByCount "149" @default.
• W2128786502 countsByYear W21287865022012 @default.
• W2128786502 countsByYear W21287865022013 @default.
• W2128786502 countsByYear W21287865022014 @default.
• W2128786502 countsByYear W21287865022015 @default.
• W2128786502 countsByYear W21287865022016 @default.
• W2128786502 countsByYear W21287865022017 @default.
• W2128786502 countsByYear W21287865022018 @default.
• W2128786502 countsByYear W21287865022019 @default.
• W2128786502 countsByYear W21287865022020 @default.
• W2128786502 countsByYear W21287865022021 @default.
• W2128786502 countsByYear W21287865022022 @default.
• W2128786502 countsByYear W21287865022023 @default.
• W2128786502 crossrefType "journal-article" @default.
• W2128786502 hasAuthorship W2128786502A5003698342 @default.
• W2128786502 hasAuthorship W2128786502A5028516152 @default.
• W2128786502 hasAuthorship W2128786502A5028954901 @default.
• W2128786502 hasAuthorship W2128786502A5034066967 @default.
• W2128786502 hasAuthorship W2128786502A5049377842 @default.
• W2128786502 hasAuthorship W2128786502A5073165630 @default.
• W2128786502 hasAuthorship W2128786502A5074801878 @default.
• W2128786502 hasBestOaLocation W21287865021 @default.
• W2128786502 hasConcept C126322002 @default.
• W2128786502 hasConcept C134018914 @default.
• W2128786502 hasConcept C176674119 @default.
• W2128786502 hasConcept C185592680 @default.
• W2128786502 hasConcept C24998067 @default.
• W2128786502 hasConcept C2776808119 @default.
• W2128786502 hasConcept C2778575703 @default.
• W2128786502 hasConcept C2778782382 @default.
• W2128786502 hasConcept C43376680 @default.
• W2128786502 hasConcept C71315377 @default.
• W2128786502 hasConcept C71924100 @default.
• W2128786502 hasConceptScore W2128786502C126322002 @default.
• W2128786502 hasConceptScore W2128786502C134018914 @default.
• W2128786502 hasConceptScore W2128786502C176674119 @default.

• next