Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128787561> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2128787561 endingPage "9" @default.
- W2128787561 startingPage "1" @default.
- W2128787561 abstract "While methacholine (MCH) testing is commonly used in the clinical diagnosis of asthma, the detection of airway narrowing often relies on either spirometry or body plethysmography, however comparative studies are rare. In this study we performed MCH testing in 37 patients with variable shortness of breath at work and in 37 patients with no history of airway disease. The inclusion criteria were: no acute respiratory infection within 6 weeks, no severe diseases, normal baseline specific airway resistance (sR(aw)), normal baseline forced expiratory volume in 1 s (FEV(1)), Tiffeneau index >70%, no previous treatment with steroids within 14 days and no short acting bronchodilators within 24 h. Cumulative doses of 0.003, 0.014, 0.059, 0.239 and 0.959 mg MCH were inhaled by a dosimeter method. A FEV(1) decrease of ≥20% from baseline and a 100% increase of sR(aw) to ≥2.0 kPa/s was defined as end-of-test-criterion. Provocation doses were calculated by interpolation. Performance of lung function parameters was compared using receiver-operating-characteristic (ROC) analysis. ROC analysis resulted in an area under the ROC curve (AUC) of 0.74 for FEV(1) vs. 0.82 for sR(aw). The corresponding Youden Indices (J) were 0.46 for FEV(1) and 0.57 for sR(aw). The Youden Index of sR(aw) was higher and sensitivity and specificity (73%/84%) were rather well-balanced, in contrast to FEV(1) (54%/92%). In conclusion, in cumulative MCH challenges sR(aw) was found to be the overall most useful parameter for the detection of bronchial hyperresponsiveness. Body plethysmography yielded a balanced sensitivity-specificity ratio with higher sensitivity than spirometry, but comparable specificity." @default.
- W2128787561 created "2016-06-24" @default.
- W2128787561 creator A5001904280 @default.
- W2128787561 creator A5006858733 @default.
- W2128787561 creator A5073797881 @default.
- W2128787561 creator A5088487393 @default.
- W2128787561 creator A5090186957 @default.
- W2128787561 date "2012-06-22" @default.
- W2128787561 modified "2023-10-13" @default.
- W2128787561 title "Assessment of Airway Hyperresponsiveness: Comparison of Spirometry and Body Plethysmography" @default.
- W2128787561 cites W1999062259 @default.
- W2128787561 cites W2026815577 @default.
- W2128787561 cites W2034110311 @default.
- W2128787561 cites W2055472916 @default.
- W2128787561 cites W2071754888 @default.
- W2128787561 cites W2087914649 @default.
- W2128787561 cites W2105883431 @default.
- W2128787561 cites W2110475616 @default.
- W2128787561 cites W2116219344 @default.
- W2128787561 cites W2121943809 @default.
- W2128787561 cites W2122068252 @default.
- W2128787561 cites W2123247260 @default.
- W2128787561 cites W2137401824 @default.
- W2128787561 cites W2145126338 @default.
- W2128787561 cites W2149772903 @default.
- W2128787561 cites W2170321108 @default.
- W2128787561 cites W2336431486 @default.
- W2128787561 cites W4294809574 @default.
- W2128787561 doi "https://doi.org/10.1007/978-94-007-4546-9_1" @default.
- W2128787561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22826043" @default.
- W2128787561 hasPublicationYear "2012" @default.
- W2128787561 type Work @default.
- W2128787561 sameAs 2128787561 @default.
- W2128787561 citedByCount "7" @default.
- W2128787561 countsByYear W21287875612015 @default.
- W2128787561 countsByYear W21287875612016 @default.
- W2128787561 countsByYear W21287875612019 @default.
- W2128787561 countsByYear W21287875612022 @default.
- W2128787561 crossrefType "book-chapter" @default.
- W2128787561 hasAuthorship W2128787561A5001904280 @default.
- W2128787561 hasAuthorship W2128787561A5006858733 @default.
- W2128787561 hasAuthorship W2128787561A5073797881 @default.
- W2128787561 hasAuthorship W2128787561A5088487393 @default.
- W2128787561 hasAuthorship W2128787561A5090186957 @default.
- W2128787561 hasConcept C105922876 @default.
- W2128787561 hasConcept C110586980 @default.
- W2128787561 hasConcept C126322002 @default.
- W2128787561 hasConcept C142724271 @default.
- W2128787561 hasConcept C164705383 @default.
- W2128787561 hasConcept C204787440 @default.
- W2128787561 hasConcept C2776042228 @default.
- W2128787561 hasConcept C2776178081 @default.
- W2128787561 hasConcept C2777714996 @default.
- W2128787561 hasConcept C2780333948 @default.
- W2128787561 hasConcept C2781260171 @default.
- W2128787561 hasConcept C33362165 @default.
- W2128787561 hasConcept C42219234 @default.
- W2128787561 hasConcept C43346845 @default.
- W2128787561 hasConcept C58471807 @default.
- W2128787561 hasConcept C71924100 @default.
- W2128787561 hasConcept C73362275 @default.
- W2128787561 hasConcept C75603125 @default.
- W2128787561 hasConceptScore W2128787561C105922876 @default.
- W2128787561 hasConceptScore W2128787561C110586980 @default.
- W2128787561 hasConceptScore W2128787561C126322002 @default.
- W2128787561 hasConceptScore W2128787561C142724271 @default.
- W2128787561 hasConceptScore W2128787561C164705383 @default.
- W2128787561 hasConceptScore W2128787561C204787440 @default.
- W2128787561 hasConceptScore W2128787561C2776042228 @default.
- W2128787561 hasConceptScore W2128787561C2776178081 @default.
- W2128787561 hasConceptScore W2128787561C2777714996 @default.
- W2128787561 hasConceptScore W2128787561C2780333948 @default.
- W2128787561 hasConceptScore W2128787561C2781260171 @default.
- W2128787561 hasConceptScore W2128787561C33362165 @default.
- W2128787561 hasConceptScore W2128787561C42219234 @default.
- W2128787561 hasConceptScore W2128787561C43346845 @default.
- W2128787561 hasConceptScore W2128787561C58471807 @default.
- W2128787561 hasConceptScore W2128787561C71924100 @default.
- W2128787561 hasConceptScore W2128787561C73362275 @default.
- W2128787561 hasConceptScore W2128787561C75603125 @default.
- W2128787561 hasLocation W21287875611 @default.
- W2128787561 hasLocation W21287875612 @default.
- W2128787561 hasOpenAccess W2128787561 @default.
- W2128787561 hasPrimaryLocation W21287875611 @default.
- W2128787561 hasRelatedWork W190431057 @default.
- W2128787561 hasRelatedWork W2100110654 @default.
- W2128787561 hasRelatedWork W2103468048 @default.
- W2128787561 hasRelatedWork W2117335259 @default.
- W2128787561 hasRelatedWork W2202739765 @default.
- W2128787561 hasRelatedWork W2256699438 @default.
- W2128787561 hasRelatedWork W2301797660 @default.
- W2128787561 hasRelatedWork W2401225735 @default.
- W2128787561 hasRelatedWork W2419064045 @default.
- W2128787561 hasRelatedWork W1911827160 @default.
- W2128787561 isParatext "false" @default.
- W2128787561 isRetracted "false" @default.
- W2128787561 magId "2128787561" @default.
- W2128787561 workType "book-chapter" @default.