Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128791806> ?p ?o ?g. }
- W2128791806 endingPage "200" @default.
- W2128791806 startingPage "139" @default.
- W2128791806 abstract "Cytochrome P450 is a membrane-bound enzyme providing oxidation of numerous organic compounds in organisms. The objective of this review is to show the wide possibilities that are provided by Electron Spin Resonance (ESR) and Nuclear Magnetic Resonance (NMR) techniques to the study of the structure and functions of this unique enzyme. High sensitivity of ESR spectra of cytochrome P450 to its functional state and interaction with substrates and inhibitors is illustrated. NMR and proton relaxation make it possible to obtain unique information about the structure of the active center of cytochrome P450 under physiological conditions. ESR and NMR methods allow one to obtain structural data on location of substrates, inhibitors, and their spin-labeled analogs with respect to Fe3+ ions in the enzyme-active center. Of special interest seems to be coupling of ESR with the affinity modification method. For this purpose, the spin-labeled analogs of cytochrome P450 substrates containing alkylating groups were used. As a result, an important datum has been obtained on the structure of active centers of cytochrome P450 in microsomes and in a highly purified state. In conclusion, the problems of the structure and functions of cytochrome P450, which can be most efficiently resolved with the use of magnetic resonance methods, are discussed." @default.
- W2128791806 created "2016-06-24" @default.
- W2128791806 creator A5068143704 @default.
- W2128791806 date "1986-01-01" @default.
- W2128791806 modified "2023-10-10" @default.
- W2128791806 title "Magnetic Resonance Study of the Structure and Functions of Cytochrome P45" @default.
- W2128791806 cites W1001616874 @default.
- W2128791806 cites W105163913 @default.
- W2128791806 cites W139983239 @default.
- W2128791806 cites W143448611 @default.
- W2128791806 cites W1482318058 @default.
- W2128791806 cites W1483640295 @default.
- W2128791806 cites W1487793176 @default.
- W2128791806 cites W1492141962 @default.
- W2128791806 cites W1497467960 @default.
- W2128791806 cites W1505168914 @default.
- W2128791806 cites W1516751460 @default.
- W2128791806 cites W1521380437 @default.
- W2128791806 cites W1530602575 @default.
- W2128791806 cites W1536166459 @default.
- W2128791806 cites W1547300654 @default.
- W2128791806 cites W1547662205 @default.
- W2128791806 cites W1550877969 @default.
- W2128791806 cites W1554131824 @default.
- W2128791806 cites W1554444467 @default.
- W2128791806 cites W1556536136 @default.
- W2128791806 cites W1557487000 @default.
- W2128791806 cites W1558356706 @default.
- W2128791806 cites W1559708145 @default.
- W2128791806 cites W1566770727 @default.
- W2128791806 cites W1572763324 @default.
- W2128791806 cites W1573792845 @default.
- W2128791806 cites W1575960438 @default.
- W2128791806 cites W1579588061 @default.
- W2128791806 cites W1581865960 @default.
- W2128791806 cites W1586039665 @default.
- W2128791806 cites W1595165457 @default.
- W2128791806 cites W1595776072 @default.
- W2128791806 cites W1602984341 @default.
- W2128791806 cites W1603055893 @default.
- W2128791806 cites W1603947018 @default.
- W2128791806 cites W1624478426 @default.
- W2128791806 cites W1674401746 @default.
- W2128791806 cites W1878922521 @default.
- W2128791806 cites W1887259747 @default.
- W2128791806 cites W1951469402 @default.
- W2128791806 cites W1956759182 @default.
- W2128791806 cites W1963547106 @default.
- W2128791806 cites W1967041190 @default.
- W2128791806 cites W1968292965 @default.
- W2128791806 cites W1968833927 @default.
- W2128791806 cites W1970375390 @default.
- W2128791806 cites W1973215717 @default.
- W2128791806 cites W1973911619 @default.
- W2128791806 cites W1974997549 @default.
- W2128791806 cites W1976090573 @default.
- W2128791806 cites W1976749670 @default.
- W2128791806 cites W1978836277 @default.
- W2128791806 cites W1980157791 @default.
- W2128791806 cites W1982592502 @default.
- W2128791806 cites W1983304521 @default.
- W2128791806 cites W1985522113 @default.
- W2128791806 cites W1985856334 @default.
- W2128791806 cites W1987056520 @default.
- W2128791806 cites W1987588083 @default.
- W2128791806 cites W1987856692 @default.
- W2128791806 cites W1989650576 @default.
- W2128791806 cites W1998176988 @default.
- W2128791806 cites W1999427782 @default.
- W2128791806 cites W2004136340 @default.
- W2128791806 cites W2004355141 @default.
- W2128791806 cites W2004607308 @default.
- W2128791806 cites W2008527374 @default.
- W2128791806 cites W2009159202 @default.
- W2128791806 cites W2010771347 @default.
- W2128791806 cites W2012102956 @default.
- W2128791806 cites W2013977257 @default.
- W2128791806 cites W2016224540 @default.
- W2128791806 cites W2017915409 @default.
- W2128791806 cites W2018067560 @default.
- W2128791806 cites W2021699700 @default.
- W2128791806 cites W2022665308 @default.
- W2128791806 cites W2023308531 @default.
- W2128791806 cites W2026911129 @default.
- W2128791806 cites W2028136131 @default.
- W2128791806 cites W2033049516 @default.
- W2128791806 cites W2037284298 @default.
- W2128791806 cites W2037873678 @default.
- W2128791806 cites W2044179782 @default.
- W2128791806 cites W2045832806 @default.
- W2128791806 cites W2050556990 @default.
- W2128791806 cites W2051574254 @default.
- W2128791806 cites W2053353249 @default.
- W2128791806 cites W2053832485 @default.
- W2128791806 cites W2055629865 @default.
- W2128791806 cites W2055925959 @default.
- W2128791806 cites W2057194913 @default.
- W2128791806 cites W2057355667 @default.