FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128794934> ?p ?o ?g. }

• W2128794934 endingPage "901" @default.
• W2128794934 startingPage "888" @default.
• W2128794934 abstract "The RNA-binding proteins of the Nanos family play an essential role in germ cell development and survival in a wide range of metazoan species. They function by suppressing the expression of target mRNAs through the recruitment of effector complexes, which include the CCR4–NOT deadenylase complex. Here, we show that the three human Nanos paralogs (Nanos1–3) interact with the CNOT1 C-terminal domain and determine the structural basis for the specific molecular recognition. Nanos1–3 bind CNOT1 through a short CNOT1-interacting motif (NIM) that is conserved in all vertebrates and some invertebrate species. The crystal structure of the human Nanos1 NIM peptide bound to CNOT1 reveals that the peptide opens a conserved hydrophobic pocket on the CNOT1 surface by inserting conserved aromatic residues. The substitutions of these aromatic residues in the Nanos1–3 NIMs abolish binding to CNOT1 and abrogate the ability of the proteins to repress translation. Our findings provide the structural basis for the recruitment of the CCR4–NOT complex by vertebrate Nanos, indicate that the NIMs are the major determinants of the translational repression mediated by Nanos, and identify the CCR4–NOT complex as the main effector complex for Nanos function." @default.
• W2128794934 created "2016-06-24" @default.
• W2128794934 creator A5034397495 @default.
• W2128794934 creator A5053073577 @default.
• W2128794934 creator A5067633818 @default.
• W2128794934 creator A5080122227 @default.
• W2128794934 creator A5087044528 @default.
• W2128794934 date "2014-04-15" @default.
• W2128794934 modified "2023-10-17" @default.
• W2128794934 title "Structural basis for the Nanos-mediated recruitment of the CCR4–NOT complex and translational repression" @default.
• W2128794934 cites W1507545655 @default.
• W2128794934 cites W1562641463 @default.
• W2128794934 cites W1876543542 @default.
• W2128794934 cites W1971349435 @default.
• W2128794934 cites W1983710378 @default.
• W2128794934 cites W1987992287 @default.
• W2128794934 cites W1999715679 @default.
• W2128794934 cites W2002095336 @default.
• W2128794934 cites W2013792719 @default.
• W2128794934 cites W2015344893 @default.
• W2128794934 cites W2016578268 @default.
• W2128794934 cites W2019719576 @default.
• W2128794934 cites W2022832110 @default.
• W2128794934 cites W2023333666 @default.
• W2128794934 cites W2030618100 @default.
• W2128794934 cites W2033045679 @default.
• W2128794934 cites W2037783502 @default.
• W2128794934 cites W2047956182 @default.
• W2128794934 cites W2048172824 @default.
• W2128794934 cites W2051808379 @default.
• W2128794934 cites W2052991419 @default.
• W2128794934 cites W2053553997 @default.
• W2128794934 cites W2057604708 @default.
• W2128794934 cites W2057641163 @default.
• W2128794934 cites W2058318950 @default.
• W2128794934 cites W2073918293 @default.
• W2128794934 cites W2080182910 @default.
• W2128794934 cites W2091544975 @default.
• W2128794934 cites W2097455031 @default.
• W2128794934 cites W2099383089 @default.
• W2128794934 cites W2102018304 @default.
• W2128794934 cites W2104377074 @default.
• W2128794934 cites W2111166800 @default.
• W2128794934 cites W2112486492 @default.
• W2128794934 cites W2124115265 @default.
• W2128794934 cites W2126036680 @default.
• W2128794934 cites W2140921290 @default.
• W2128794934 cites W2141172277 @default.
• W2128794934 cites W2150014745 @default.
• W2128794934 cites W2153368605 @default.
• W2128794934 cites W2153745204 @default.
• W2128794934 cites W2154179678 @default.
• W2128794934 cites W2157191293 @default.
• W2128794934 cites W2159107837 @default.
• W2128794934 cites W2166708209 @default.
• W2128794934 cites W2181464620 @default.
• W2128794934 cites W2212672342 @default.
• W2128794934 doi "https://doi.org/10.1101/gad.237289.113" @default.
• W2128794934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4003280" @default.
• W2128794934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24736845" @default.
• W2128794934 hasPublicationYear "2014" @default.
• W2128794934 type Work @default.
• W2128794934 sameAs 2128794934 @default.
• W2128794934 citedByCount "90" @default.
• W2128794934 countsByYear W21287949342014 @default.
• W2128794934 countsByYear W21287949342015 @default.
• W2128794934 countsByYear W21287949342016 @default.
• W2128794934 countsByYear W21287949342017 @default.
• W2128794934 countsByYear W21287949342018 @default.
• W2128794934 countsByYear W21287949342019 @default.
• W2128794934 countsByYear W21287949342020 @default.
• W2128794934 countsByYear W21287949342021 @default.
• W2128794934 countsByYear W21287949342022 @default.
• W2128794934 countsByYear W21287949342023 @default.
• W2128794934 crossrefType "journal-article" @default.
• W2128794934 hasAuthorship W2128794934A5034397495 @default.
• W2128794934 hasAuthorship W2128794934A5053073577 @default.
• W2128794934 hasAuthorship W2128794934A5067633818 @default.
• W2128794934 hasAuthorship W2128794934A5080122227 @default.
• W2128794934 hasAuthorship W2128794934A5087044528 @default.
• W2128794934 hasBestOaLocation W21287949341 @default.
• W2128794934 hasConcept C104317684 @default.
• W2128794934 hasConcept C105580179 @default.
• W2128794934 hasConcept C132677234 @default.
• W2128794934 hasConcept C14036430 @default.
• W2128794934 hasConcept C149364088 @default.
• W2128794934 hasConcept C150194340 @default.
• W2128794934 hasConcept C167625842 @default.
• W2128794934 hasConcept C186310378 @default.
• W2128794934 hasConcept C199216141 @default.
• W2128794934 hasConcept C51785407 @default.
• W2128794934 hasConcept C54355233 @default.
• W2128794934 hasConcept C55493867 @default.
• W2128794934 hasConcept C70721500 @default.
• W2128794934 hasConcept C86803240 @default.
• W2128794934 hasConcept C95444343 @default.
• W2128794934 hasConceptScore W2128794934C104317684 @default.
• W2128794934 hasConceptScore W2128794934C105580179 @default.

• next