FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128797551> ?p ?o ?g. }

• W2128797551 endingPage "4011" @default.
• W2128797551 startingPage "4004" @default.
• W2128797551 abstract "Lrp (leucine-responsive regulatory protein) plays a global regulatory role in Escherichia coli, affecting expression of dozens of operons. Numerous lrp-related genes have been identified in different bacteria and archaea, including asnC, an E. coli gene that was the first reported member of this family. Pairwise comparisons of amino acid sequences of the corresponding proteins shows an average sequence identity of only 29% for the vast majority of comparisons. By contrast, Lrp-related proteins from enteric bacteria show more than 97% amino acid identity. Is the global regulatory role associated with E. coli Lrp limited to enteric bacteria? To probe this question we investigated LrfB, an Lrp-related protein from Haemophilus influenzae that shares 75% sequence identity with E. coli Lrp (highest sequence identity among 42 sequences compared). A strain of H. influenzae having an lrfB null allele grew at the wild-type growth rate but with a filamentous morphology. A comparison of two-dimensional (2D) electrophoretic patterns of proteins from parent and mutant strains showed only two differences (comparable studies with lrp(+) and lrp E. coli strains by others showed 20 differences). The abundance of LrfB in H. influenzae, estimated by Western blotting experiments, was about 130 dimers per cell (compared to 3,000 dimers per E. coli cell). LrfB expressed in E. coli replaced Lrp as a repressor of the lrp gene but acted only to a limited extent as an activator of the ilvIH operon. Thus, although LrfB resembles Lrp sufficiently to perform some of its functions, its low abundance is consonant with a more local role in regulating but a few genes, a view consistent with the results of the 2D electrophoretic analysis. We speculate that an Lrp having a global regulatory role evolved to help enteric bacteria adapt to their ecological niches and that it is unlikely that Lrp-related proteins in other organisms have a broad regulatory function." @default.
• W2128797551 created "2016-06-24" @default.
• W2128797551 creator A5009625205 @default.
• W2128797551 creator A5037033375 @default.
• W2128797551 creator A5068528147 @default.
• W2128797551 date "2001-07-01" @default.
• W2128797551 modified "2023-09-23" @default.
• W2128797551 title "Global versus Local Regulatory Roles for Lrp-Related Proteins: <i>Haemophilus influenzae</i> as a Case Study" @default.
• W2128797551 cites W1443898972 @default.
• W2128797551 cites W1481299334 @default.
• W2128797551 cites W1483293912 @default.
• W2128797551 cites W1508571169 @default.
• W2128797551 cites W1511864084 @default.
• W2128797551 cites W1532830348 @default.
• W2128797551 cites W1553008332 @default.
• W2128797551 cites W1569816451 @default.
• W2128797551 cites W1590648220 @default.
• W2128797551 cites W1595785419 @default.
• W2128797551 cites W1601543464 @default.
• W2128797551 cites W1606423922 @default.
• W2128797551 cites W1608563072 @default.
• W2128797551 cites W184664806 @default.
• W2128797551 cites W1883250823 @default.
• W2128797551 cites W1898450481 @default.
• W2128797551 cites W1909672973 @default.
• W2128797551 cites W1969506862 @default.
• W2128797551 cites W1971403296 @default.
• W2128797551 cites W2009310436 @default.
• W2128797551 cites W2022351915 @default.
• W2128797551 cites W2038572730 @default.
• W2128797551 cites W2051449352 @default.
• W2128797551 cites W2055043387 @default.
• W2128797551 cites W2057443273 @default.
• W2128797551 cites W2076576194 @default.
• W2128797551 cites W2079102383 @default.
• W2128797551 cites W2115627175 @default.
• W2128797551 cites W2122669252 @default.
• W2128797551 cites W2129364846 @default.
• W2128797551 cites W2137421566 @default.
• W2128797551 cites W2138270253 @default.
• W2128797551 cites W2138542468 @default.
• W2128797551 cites W2143394586 @default.
• W2128797551 cites W2155468175 @default.
• W2128797551 cites W2402042156 @default.
• W2128797551 doi "https://doi.org/10.1128/jb.183.13.4004-4011.2001" @default.
• W2128797551 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/95284" @default.
• W2128797551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11395465" @default.
• W2128797551 hasPublicationYear "2001" @default.
• W2128797551 type Work @default.
• W2128797551 sameAs 2128797551 @default.
• W2128797551 citedByCount "28" @default.
• W2128797551 countsByYear W21287975512013 @default.
• W2128797551 countsByYear W21287975512016 @default.
• W2128797551 countsByYear W21287975512021 @default.
• W2128797551 countsByYear W21287975512023 @default.
• W2128797551 crossrefType "journal-article" @default.
• W2128797551 hasAuthorship W2128797551A5009625205 @default.
• W2128797551 hasAuthorship W2128797551A5037033375 @default.
• W2128797551 hasAuthorship W2128797551A5068528147 @default.
• W2128797551 hasBestOaLocation W21287975512 @default.
• W2128797551 hasConcept C104317684 @default.
• W2128797551 hasConcept C150194340 @default.
• W2128797551 hasConcept C153911025 @default.
• W2128797551 hasConcept C158448853 @default.
• W2128797551 hasConcept C167625842 @default.
• W2128797551 hasConcept C203075996 @default.
• W2128797551 hasConcept C2776925733 @default.
• W2128797551 hasConcept C523546767 @default.
• W2128797551 hasConcept C54355233 @default.
• W2128797551 hasConcept C547475151 @default.
• W2128797551 hasConcept C86803240 @default.
• W2128797551 hasConcept C89423630 @default.
• W2128797551 hasConceptScore W2128797551C104317684 @default.
• W2128797551 hasConceptScore W2128797551C150194340 @default.
• W2128797551 hasConceptScore W2128797551C153911025 @default.
• W2128797551 hasConceptScore W2128797551C158448853 @default.
• W2128797551 hasConceptScore W2128797551C167625842 @default.
• W2128797551 hasConceptScore W2128797551C203075996 @default.
• W2128797551 hasConceptScore W2128797551C2776925733 @default.
• W2128797551 hasConceptScore W2128797551C523546767 @default.
• W2128797551 hasConceptScore W2128797551C54355233 @default.
• W2128797551 hasConceptScore W2128797551C547475151 @default.
• W2128797551 hasConceptScore W2128797551C86803240 @default.
• W2128797551 hasConceptScore W2128797551C89423630 @default.
• W2128797551 hasIssue "13" @default.
• W2128797551 hasLocation W21287975511 @default.
• W2128797551 hasLocation W21287975512 @default.
• W2128797551 hasLocation W21287975513 @default.
• W2128797551 hasLocation W21287975514 @default.
• W2128797551 hasOpenAccess W2128797551 @default.
• W2128797551 hasPrimaryLocation W21287975511 @default.
• W2128797551 hasRelatedWork W1002981616 @default.
• W2128797551 hasRelatedWork W110945905 @default.
• W2128797551 hasRelatedWork W1542478099 @default.
• W2128797551 hasRelatedWork W2036347073 @default.
• W2128797551 hasRelatedWork W2153122502 @default.
• W2128797551 hasRelatedWork W2171277769 @default.
• W2128797551 hasRelatedWork W2340299574 @default.

• next