Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128810146> ?p ?o ?g. }
- W2128810146 endingPage "1274" @default.
- W2128810146 startingPage "1263" @default.
- W2128810146 abstract "Cadherins and integrins must function in a coordinated manner to effectively mediate the cellular interactions essential for development. We hypothesized that exchange of proteins associated with their cytoplasmic domains may play a role in coordinating function. To test this idea, we used Trojan peptides to introduce into cells and tissues peptide sequences designed to compete for the interaction of specific effectors with the cytoplasmic domain of N-cadherin, and assayed their effect on cadherin- and integrin-mediated adhesion and neurite outgrowth. We show that a peptide mimicking the juxtamembrane (JMP) region of the cytoplasmic domain of N-cadherin results in inhibition of N-cadherin and beta1-integrin function. The effect of JMP on beta1-integrin function depends on the expression of N-cadherin and is independent of transcription or translation. Treatment of cells with JMP results in the release of the nonreceptor tyrosine kinase Fer from the cadherin complex and its accumulation in the integrin complex. A peptide that mimics the first coiled-coil domain of Fer prevents Fer accumulation in the integrin complex and reverses the inhibitory effect of JMP. These findings suggest a new mechanism through which N-cadherin and beta1-integrins are coordinately regulated: loss of an effector from the cytoplasmic domain of N-cadherin and gain of that effector by the beta1-integrin complex." @default.
- W2128810146 created "2016-06-24" @default.
- W2128810146 creator A5009346937 @default.
- W2128810146 creator A5030986126 @default.
- W2128810146 creator A5053725552 @default.
- W2128810146 creator A5073844142 @default.
- W2128810146 date "2000-06-12" @default.
- W2128810146 modified "2023-10-14" @default.
- W2128810146 title "The Nonreceptor Tyrosine Kinase Fer Mediates Cross-Talk between N-Cadherin and β1-Integrins" @default.
- W2128810146 cites W130263754 @default.
- W2128810146 cites W1504652010 @default.
- W2128810146 cites W1571511764 @default.
- W2128810146 cites W1579092896 @default.
- W2128810146 cites W1584683177 @default.
- W2128810146 cites W1606012461 @default.
- W2128810146 cites W1859151740 @default.
- W2128810146 cites W1900495018 @default.
- W2128810146 cites W1912597193 @default.
- W2128810146 cites W1967385749 @default.
- W2128810146 cites W1972659626 @default.
- W2128810146 cites W1973466009 @default.
- W2128810146 cites W1977517182 @default.
- W2128810146 cites W1978031202 @default.
- W2128810146 cites W1982223015 @default.
- W2128810146 cites W1984872320 @default.
- W2128810146 cites W1990215042 @default.
- W2128810146 cites W1992267627 @default.
- W2128810146 cites W1994478382 @default.
- W2128810146 cites W1995572593 @default.
- W2128810146 cites W1999010087 @default.
- W2128810146 cites W1999673185 @default.
- W2128810146 cites W2000773327 @default.
- W2128810146 cites W2001306989 @default.
- W2128810146 cites W2001796760 @default.
- W2128810146 cites W2006705432 @default.
- W2128810146 cites W2008883939 @default.
- W2128810146 cites W2010822247 @default.
- W2128810146 cites W2010938418 @default.
- W2128810146 cites W2016131735 @default.
- W2128810146 cites W2020283231 @default.
- W2128810146 cites W2020504648 @default.
- W2128810146 cites W2023618495 @default.
- W2128810146 cites W2027937187 @default.
- W2128810146 cites W2029231027 @default.
- W2128810146 cites W2032345748 @default.
- W2128810146 cites W2034710767 @default.
- W2128810146 cites W2036145275 @default.
- W2128810146 cites W2047392037 @default.
- W2128810146 cites W2050750704 @default.
- W2128810146 cites W2053947462 @default.
- W2128810146 cites W2055354269 @default.
- W2128810146 cites W2057138636 @default.
- W2128810146 cites W2061304971 @default.
- W2128810146 cites W2065715916 @default.
- W2128810146 cites W2066045232 @default.
- W2128810146 cites W2068124694 @default.
- W2128810146 cites W2069526456 @default.
- W2128810146 cites W2071872700 @default.
- W2128810146 cites W2076551313 @default.
- W2128810146 cites W2078862404 @default.
- W2128810146 cites W2082915574 @default.
- W2128810146 cites W2087917270 @default.
- W2128810146 cites W2090692266 @default.
- W2128810146 cites W2098081034 @default.
- W2128810146 cites W2101435003 @default.
- W2128810146 cites W2116596989 @default.
- W2128810146 cites W2116874369 @default.
- W2128810146 cites W2119609292 @default.
- W2128810146 cites W2120492537 @default.
- W2128810146 cites W2132888121 @default.
- W2128810146 cites W2133527571 @default.
- W2128810146 cites W2143902279 @default.
- W2128810146 cites W2152396103 @default.
- W2128810146 cites W2155515810 @default.
- W2128810146 cites W2155723800 @default.
- W2128810146 cites W2159624278 @default.
- W2128810146 cites W2163951902 @default.
- W2128810146 cites W2165868086 @default.
- W2128810146 cites W2167309932 @default.
- W2128810146 cites W2169310627 @default.
- W2128810146 cites W2189426703 @default.
- W2128810146 cites W2407432304 @default.
- W2128810146 cites W2468408469 @default.
- W2128810146 cites W3059118 @default.
- W2128810146 cites W4234936605 @default.
- W2128810146 cites W4243228481 @default.
- W2128810146 cites W48910532 @default.
- W2128810146 doi "https://doi.org/10.1083/jcb.149.6.1263" @default.
- W2128810146 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2175119" @default.
- W2128810146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10851023" @default.
- W2128810146 hasPublicationYear "2000" @default.
- W2128810146 type Work @default.
- W2128810146 sameAs 2128810146 @default.
- W2128810146 citedByCount "119" @default.
- W2128810146 countsByYear W21288101462012 @default.
- W2128810146 countsByYear W21288101462013 @default.
- W2128810146 countsByYear W21288101462014 @default.
- W2128810146 countsByYear W21288101462015 @default.