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- W2128822902 endingPage "7062" @default.
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- W2128822902 abstract "ABSTRACT Two redox proteins, azurin and cytochrome c 551 elaborated by Pseudomonas aeruginosa , demonstrate significant cytotoxic activity towards macrophages. Azurin can enter macrophages, localize in the cytosol and nuclear fractions, and induce apoptosis. Two redox-negative mutants of azurin have less cytotoxicity than does wild-type (wt) azurin. Azurin has been shown to form a complex with the tumor suppressor protein p53, a known inducer of apoptosis, thereby stabilizing it and enhancing its intracellular level. A higher level of reactive oxygen species (ROS), generated during treatment of macrophages with wt azurin, correlates with its cytotoxicity. Treatment with some ROS-removing antioxidants greatly reduces azurin-mediated cytotoxicity, thus demonstrating a novel virulence property of this bacterial redox protein." @default.
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- W2128822902 date "2002-12-01" @default.
- W2128822902 modified "2023-10-18" @default.
- W2128822902 title "The Bacterial Redox Protein Azurin Induces Apoptosis in J774 Macrophages through Complex Formation and Stabilization of the Tumor Suppressor Protein p53" @default.
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- W2128822902 doi "https://doi.org/10.1128/iai.70.12.7054-7062.2002" @default.
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