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- W2128869282 abstract "HDAC inhibitors show great promise for the treatment of cancer. As part of a broader effort to explore the SAR of HDAC inhibitors, synthesis, biological evaluation, and molecular docking of novel Ugi products containing a zinc-chelating moiety are presented. One compound shows improved inhibitory potencies compared to SAHA, demonstrating that hindered lipophilic residues grafted on the peptide scaffold of the alpha-aminoacylamides can be favorable in the interaction with the enzyme." @default.
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- W2128869282 date "2009-04-03" @default.
- W2128869282 modified "2023-10-18" @default.
- W2128869282 title "Synthesis, Biological Evaluation, and Molecular Docking of Ugi Products Containing a Zinc-Chelating Moiety as Novel Inhibitors of Histone Deacetylases" @default.
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- W2128869282 doi "https://doi.org/10.1021/jm801529c" @default.
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