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• W2128942012 abstract "Chronic medicated patients with schizophrenia have marked reductions in sleep spindle activity and a correlated deficit in sleep-dependent memory consolidation. Using archival data, we investigated whether antipsychotic-naïve early course patients with schizophrenia and young non-psychotic first-degree relatives of patients with schizophrenia also show reduced sleep spindle activity and whether spindle activity correlates with cognitive function and symptoms.Sleep spindles during Stage 2 sleep were compared in antipsychotic-naïve adults newly diagnosed with psychosis, young non-psychotic first-degree relatives of schizophrenia patients and two samples of healthy controls matched to the patients and relatives. The relations of spindle parameters with cognitive measures and symptom ratings were examined.Early course schizophrenia patients showed significantly reduced spindle activity relative to healthy controls and to early course patients with other psychotic disorders. Relatives of schizophrenia patients also showed reduced spindle activity compared with controls. Reduced spindle activity correlated with measures of executive function in early course patients, positive symptoms in schizophrenia and IQ estimates across groups.Like chronic medicated schizophrenia patients, antipsychotic-naïve early course schizophrenia patients and young non-psychotic relatives of individuals with schizophrenia have reduced sleep spindle activity. These findings indicate that the spindle deficit is not an antipsychotic side-effect or a general feature of psychosis. Instead, the spindle deficit may predate the onset of schizophrenia, persist throughout its course and be an endophenotype that contributes to cognitive dysfunction." @default.
• W2128942012 created "2016-06-24" @default.
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• W2128942012 date "2014-10-07" @default.
• W2128942012 modified "2023-10-15" @default.
• W2128942012 title "Sleep spindle deficits in antipsychotic-naïve early course schizophrenia and in non-psychotic first-degree relatives" @default.
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• W2128942012 cites W1533892631 @default.
• W2128942012 cites W1555810878 @default.
• W2128942012 cites W1967601734 @default.
• W2128942012 cites W1968796419 @default.
• W2128942012 cites W1969699052 @default.
• W2128942012 cites W1970593689 @default.
• W2128942012 cites W1972078968 @default.
• W2128942012 cites W1975114050 @default.
• W2128942012 cites W1975812749 @default.
• W2128942012 cites W1984808927 @default.
• W2128942012 cites W1987835654 @default.
• W2128942012 cites W1987908885 @default.
• W2128942012 cites W1988190588 @default.
• W2128942012 cites W1991686881 @default.
• W2128942012 cites W1992225639 @default.
• W2128942012 cites W1992510645 @default.
• W2128942012 cites W1993604594 @default.
• W2128942012 cites W2000555003 @default.
• W2128942012 cites W2003326720 @default.
• W2128942012 cites W2007206857 @default.
• W2128942012 cites W2013179939 @default.
• W2128942012 cites W2016905861 @default.
• W2128942012 cites W2018590161 @default.
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• W2128942012 cites W2042317394 @default.
• W2128942012 cites W2044342959 @default.
• W2128942012 cites W2046305796 @default.
• W2128942012 cites W2051865632 @default.
• W2128942012 cites W2055195147 @default.
• W2128942012 cites W2064155672 @default.
• W2128942012 cites W2072602886 @default.
• W2128942012 cites W2073025039 @default.
• W2128942012 cites W2074446477 @default.
• W2128942012 cites W2077360449 @default.
• W2128942012 cites W2077633827 @default.
• W2128942012 cites W2077875845 @default.
• W2128942012 cites W2078881206 @default.
• W2128942012 cites W2080386007 @default.
• W2128942012 cites W2083355945 @default.
• W2128942012 cites W2085829786 @default.
• W2128942012 cites W2089846607 @default.
• W2128942012 cites W2090581304 @default.
• W2128942012 cites W2094616210 @default.
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• W2128942012 cites W2106935171 @default.
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• W2128942012 cites W2163657807 @default.
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• W2128942012 cites W2170139952 @default.
• W2128942012 cites W2170726625 @default.
• W2128942012 cites W2171013464 @default.
• W2128942012 cites W2213127880 @default.
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• W2128942012 doi "https://doi.org/10.3389/fnhum.2014.00762" @default.
• W2128942012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4188028" @default.
• W2128942012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25339881" @default.
• W2128942012 hasPublicationYear "2014" @default.
• W2128942012 type Work @default.
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• W2128942012 citedByCount "117" @default.

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