FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2128949364> ?p ?o ?g. }

• W2128949364 endingPage "15073" @default.
• W2128949364 startingPage "15064" @default.
• W2128949364 abstract "ABSTRACT Murine hepatitis virus (MHV) infection provides a model system for the study of hepatitis, acute encephalitis, and chronic demyelinating disease. The spike glycoprotein, S, which mediates receptor binding and membrane fusion, plays a critical role in MHV pathogenesis. However, viral proteins other than S also contribute to pathogenicity. The JHM strain of MHV is highly neurovirulent and expresses a second spike glycoprotein, the hemagglutinin esterase (HE), which is not produced by MHV-A59, a hepatotropic but only mildly neurovirulent strain. To investigate a possible role for HE in MHV-induced neurovirulence, isogenic recombinant MHV-A59 viruses were generated that produced either (i) the wild-type protein, (ii) an enzymatically inactive HE protein, or (iii) no HE at all (A. Lissenberg, M. M. Vrolijk, A. L. W. van Vliet, M. A. Langereis, J. D. F. de Groot-Mijnes, P. J. M. Rottier, and R. J. de Groot, J. Virol. 79: 15054-15063, 2005 [accompanying paper]). A second, mirror set of recombinant viruses was constructed in which, in addition, the MHV-A59 S gene had been replaced with that from MHV-JHM. The expression of HE in combination with A59 S did not affect the tropism, pathogenicity, or spread of the virus in vivo. However, in combination with JHM S, the expression of HE, regardless of whether it retained esterase activity or not, resulted in increased viral spread within the central nervous system and in increased neurovirulence. Our findings suggest that the properties of S receptor utilization and/or fusogenicity mainly determine organ and host cell tropism but that HE enhances the efficiency of infection and promotes viral dissemination, at least in some tissues, presumably by serving as a second receptor-binding protein." @default.
• W2128949364 created "2016-06-24" @default.
• W2128949364 creator A5026530794 @default.
• W2128949364 creator A5030517401 @default.
• W2128949364 creator A5041349256 @default.
• W2128949364 creator A5053303084 @default.
• W2128949364 creator A5069103882 @default.
• W2128949364 date "2005-12-15" @default.
• W2128949364 modified "2023-10-16" @default.
• W2128949364 title "Expression of Hemagglutinin Esterase Protein from Recombinant Mouse Hepatitis Virus Enhances Neurovirulence" @default.
• W2128949364 cites W119712977 @default.
• W2128949364 cites W1542641435 @default.
• W2128949364 cites W1582853114 @default.
• W2128949364 cites W1733180971 @default.
• W2128949364 cites W179501628 @default.
• W2128949364 cites W1873774238 @default.
• W2128949364 cites W1902549931 @default.
• W2128949364 cites W1907939172 @default.
• W2128949364 cites W1913128941 @default.
• W2128949364 cites W1959122025 @default.
• W2128949364 cites W1965622975 @default.
• W2128949364 cites W1968038125 @default.
• W2128949364 cites W1976725774 @default.
• W2128949364 cites W1977519536 @default.
• W2128949364 cites W1979347763 @default.
• W2128949364 cites W1985656813 @default.
• W2128949364 cites W1985916880 @default.
• W2128949364 cites W1997482909 @default.
• W2128949364 cites W2004402874 @default.
• W2128949364 cites W2006785079 @default.
• W2128949364 cites W2008920231 @default.
• W2128949364 cites W2012605222 @default.
• W2128949364 cites W2012735174 @default.
• W2128949364 cites W2013930155 @default.
• W2128949364 cites W2017348940 @default.
• W2128949364 cites W2019723399 @default.
• W2128949364 cites W2029444429 @default.
• W2128949364 cites W2030026320 @default.
• W2128949364 cites W2038231410 @default.
• W2128949364 cites W2043355913 @default.
• W2128949364 cites W2061397668 @default.
• W2128949364 cites W2070082557 @default.
• W2128949364 cites W2078917493 @default.
• W2128949364 cites W2080602636 @default.
• W2128949364 cites W2097188280 @default.
• W2128949364 cites W2099438843 @default.
• W2128949364 cites W2099801939 @default.
• W2128949364 cites W2099950465 @default.
• W2128949364 cites W2104548316 @default.
• W2128949364 cites W2111412754 @default.
• W2128949364 cites W2113624851 @default.
• W2128949364 cites W2116586125 @default.
• W2128949364 cites W2120567521 @default.
• W2128949364 cites W2134972446 @default.
• W2128949364 cites W2143434875 @default.
• W2128949364 cites W2146686723 @default.
• W2128949364 cites W2151503983 @default.
• W2128949364 cites W2154763448 @default.
• W2128949364 cites W2160004392 @default.
• W2128949364 cites W2162175694 @default.
• W2128949364 cites W2164087646 @default.
• W2128949364 cites W2167344089 @default.
• W2128949364 cites W2169198329 @default.
• W2128949364 cites W2170933940 @default.
• W2128949364 cites W2343299248 @default.
• W2128949364 cites W2411782668 @default.
• W2128949364 cites W2427415 @default.
• W2128949364 cites W2465852065 @default.
• W2128949364 cites W71772434 @default.
• W2128949364 cites W80651316 @default.
• W2128949364 doi "https://doi.org/10.1128/jvi.79.24.15064-15073.2005" @default.
• W2128949364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1316009" @default.
• W2128949364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16306577" @default.
• W2128949364 hasPublicationYear "2005" @default.
• W2128949364 type Work @default.
• W2128949364 sameAs 2128949364 @default.
• W2128949364 citedByCount "58" @default.
• W2128949364 countsByYear W21289493642012 @default.
• W2128949364 countsByYear W21289493642013 @default.
• W2128949364 countsByYear W21289493642014 @default.
• W2128949364 countsByYear W21289493642015 @default.
• W2128949364 countsByYear W21289493642016 @default.
• W2128949364 countsByYear W21289493642018 @default.
• W2128949364 countsByYear W21289493642019 @default.
• W2128949364 countsByYear W21289493642020 @default.
• W2128949364 countsByYear W21289493642021 @default.
• W2128949364 countsByYear W21289493642023 @default.
• W2128949364 crossrefType "journal-article" @default.
• W2128949364 hasAuthorship W2128949364A5026530794 @default.
• W2128949364 hasAuthorship W2128949364A5030517401 @default.
• W2128949364 hasAuthorship W2128949364A5041349256 @default.
• W2128949364 hasAuthorship W2128949364A5053303084 @default.
• W2128949364 hasAuthorship W2128949364A5069103882 @default.
• W2128949364 hasBestOaLocation W21289493641 @default.
• W2128949364 hasConcept C104317684 @default.
• W2128949364 hasConcept C108625454 @default.
• W2128949364 hasConcept C142724271 @default.
• W2128949364 hasConcept C153911025 @default.

• next