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• W2128995604 endingPage "C787" @default.
• W2128995604 startingPage "C775" @default.
• W2128995604 abstract "Tight junctions (TJs) form a barrier to the paracellular diffusion of ions and solutes across epithelia. Although transmembrane proteins of the claudin family have emerged as critical determinants of TJ permeability, little is known about the signaling pathways that control their expression. The aim of this study was to assess the role of three mitogen-activated protein kinases (MAPKs), i.e., extracellular signal-regulated kinase-1/2 (ERK1/2), c-Jun NH 2 -terminal kinases (JNKs), and p38 kinases, in the regulation of epithelial barrier function and claudin expression in mammary epithelial cells. Addition of either PD169316 (a p38 inhibitor) or SP600125 (a JNK inhibitor) induced formation of domes (a phenomenon dependent on TJ barrier function) and enhanced transepithelial electrical resistance, whereas U0126 (an inhibitor of the ERK1/2 activators MEK1/MEK2) had no significant effect. Similar results were obtained using mechanistically unrelated p38 or JNK inhibitors. PD169316 increased the expression of claudin-4 and -8, whereas SP600125 increased claudin-4 and -9 and downregulated claudin-8. Silencing of p38α by isoform-specific small interfering RNAs increased claudin-4 and -8 mRNAs, whereas silencing of p38β only increased claudin-4 mRNA. Silencing of either JNK1 or JNK2 increased claudin-9 mRNA expression while decreasing claudin-8 mRNA. Moreover, selective silencing of JNK2 increased claudin-4 and -7 mRNAs. Finally, both PD169316 and SP600125 inhibited the paracellular diffusion of Na + and Cl − across epithelial monolayers. Collectively, these results provide evidence that inhibition of either p38 or JNK enhances epithelial barrier function by selectively modulating claudin expression, implying that the basal activity of these MAPKs exerts a tonic effect on TJ ionic permeability." @default.
• W2128995604 created "2016-06-24" @default.
• W2128995604 creator A5011382877 @default.
• W2128995604 creator A5053740828 @default.
• W2128995604 creator A5060333134 @default.
• W2128995604 creator A5063901746 @default.
• W2128995604 date "2009-09-01" @default.
• W2128995604 modified "2023-10-11" @default.
• W2128995604 title "Inhibition of basal p38 or JNK activity enhances epithelial barrier function through differential modulation of claudin expression" @default.
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• W2128995604 doi "https://doi.org/10.1152/ajpcell.00084.2009" @default.
• W2128995604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19605737" @default.
• W2128995604 hasPublicationYear "2009" @default.
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