FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129005313> ?p ?o ?g. }

• W2129005313 endingPage "1711" @default.
• W2129005313 startingPage "1699" @default.
• W2129005313 abstract "ABSTRACT The predominant cell wall melanin of Wangiella dermatitidis , a black fungal pathogen of humans, is synthesized from 1,8-dihydroxynaphthalene (D2HN). An early precursor, 1,3,6,8-tetrahydroxynaphthalene (T4HN), in the pathway leading to D2HN is reportedly produced directly as a pentaketide by an iterative type I polyketide synthase (PKS). In contrast, the bluish-green pigment in Aspergillus fumigatus is produced after the enzyme Ayg1p converts the PKS product, the heptaketide YWA1, to T4HN. Previously, we created a new melanin-deficient mutant of W. dermatitidis , WdBrm1, by random molecular insertion. From this strain, the altered gene Wd YG1 was cloned by a marker rescue strategy and found to encode WdYg1p, an ortholog of Ayg1p. In the present study, two gene replacement mutants devoid of the complete Wd YG1 gene were derived to eliminate the possibility that the phenotype of WdBrm1 was due to other mutations. Characterization of the new mutants showed that they were phenotypically identical to WdBrm1. Chemical analyses of mutant cultures demonstrated that melanin biosynthesis was blocked, resulting in the accumulation of 2-acetyl-1,3,6,8-tetrahydroxynaphthalene (AT4HN) and its oxidative product 3-acetylflaviolin in the culture media. When given to an albino W. dermatitidis strain with an inactivated Wd PKS1 gene, AT4HN was mostly oxidized to 3-acetylflaviolin and deacetylated to flaviolin. Under reduced oxygen conditions, cell-free homogenates of the albino converted AT4HN to D2HN. This is the first report of evidence that the hexaketide AT4HN is a melanin precursor for T4HN in W. dermatitidis ." @default.
• W2129005313 created "2016-06-24" @default.
• W2129005313 creator A5004651925 @default.
• W2129005313 creator A5025446166 @default.
• W2129005313 creator A5032124937 @default.
• W2129005313 creator A5067802887 @default.
• W2129005313 creator A5071290482 @default.
• W2129005313 creator A5077273227 @default.
• W2129005313 creator A5081268011 @default.
• W2129005313 date "2008-10-01" @default.
• W2129005313 modified "2023-10-01" @default.
• W2129005313 title "New Biosynthetic Step in the Melanin Pathway of <i>Wangiella</i> ( <i>Exophiala</i> ) <i>dermatitidis</i> : Evidence for 2-Acetyl-1,3,6,8-Tetrahydroxynaphthalene as a Novel Precursor" @default.
• W2129005313 cites W1528058618 @default.
• W2129005313 cites W1719373811 @default.
• W2129005313 cites W1972708413 @default.
• W2129005313 cites W1975920595 @default.
• W2129005313 cites W1976801871 @default.
• W2129005313 cites W2006322995 @default.
• W2129005313 cites W2012282253 @default.
• W2129005313 cites W2012621876 @default.
• W2129005313 cites W2019168819 @default.
• W2129005313 cites W2028735106 @default.
• W2129005313 cites W2035247351 @default.
• W2129005313 cites W2043267681 @default.
• W2129005313 cites W2044456130 @default.
• W2129005313 cites W2050460127 @default.
• W2129005313 cites W2057188662 @default.
• W2129005313 cites W2064508279 @default.
• W2129005313 cites W2067883598 @default.
• W2129005313 cites W2072513422 @default.
• W2129005313 cites W2096404488 @default.
• W2129005313 cites W2104633998 @default.
• W2129005313 cites W2106882534 @default.
• W2129005313 cites W2117120347 @default.
• W2129005313 cites W2118255900 @default.
• W2129005313 cites W2119145987 @default.
• W2129005313 cites W2129638708 @default.
• W2129005313 cites W2133216847 @default.
• W2129005313 cites W2135280679 @default.
• W2129005313 cites W2136984408 @default.
• W2129005313 cites W2138060405 @default.
• W2129005313 cites W2142603650 @default.
• W2129005313 cites W2145259682 @default.
• W2129005313 cites W2158714788 @default.
• W2129005313 cites W2160881018 @default.
• W2129005313 cites W2162379022 @default.
• W2129005313 cites W2166258467 @default.
• W2129005313 cites W2167458607 @default.
• W2129005313 cites W2233516371 @default.
• W2129005313 cites W2331233649 @default.
• W2129005313 cites W4211086973 @default.
• W2129005313 doi "https://doi.org/10.1128/ec.00179-08" @default.
• W2129005313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2568069" @default.
• W2129005313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18676950" @default.
• W2129005313 hasPublicationYear "2008" @default.
• W2129005313 type Work @default.
• W2129005313 sameAs 2129005313 @default.
• W2129005313 citedByCount "61" @default.
• W2129005313 countsByYear W21290053132012 @default.
• W2129005313 countsByYear W21290053132013 @default.
• W2129005313 countsByYear W21290053132014 @default.
• W2129005313 countsByYear W21290053132015 @default.
• W2129005313 countsByYear W21290053132016 @default.
• W2129005313 countsByYear W21290053132017 @default.
• W2129005313 countsByYear W21290053132018 @default.
• W2129005313 countsByYear W21290053132019 @default.
• W2129005313 countsByYear W21290053132020 @default.
• W2129005313 countsByYear W21290053132021 @default.
• W2129005313 countsByYear W21290053132022 @default.
• W2129005313 countsByYear W21290053132023 @default.
• W2129005313 crossrefType "journal-article" @default.
• W2129005313 hasAuthorship W2129005313A5004651925 @default.
• W2129005313 hasAuthorship W2129005313A5025446166 @default.
• W2129005313 hasAuthorship W2129005313A5032124937 @default.
• W2129005313 hasAuthorship W2129005313A5067802887 @default.
• W2129005313 hasAuthorship W2129005313A5071290482 @default.
• W2129005313 hasAuthorship W2129005313A5077273227 @default.
• W2129005313 hasAuthorship W2129005313A5081268011 @default.
• W2129005313 hasBestOaLocation W21290053131 @default.
• W2129005313 hasConcept C104317684 @default.
• W2129005313 hasConcept C107538193 @default.
• W2129005313 hasConcept C127716648 @default.
• W2129005313 hasConcept C143065580 @default.
• W2129005313 hasConcept C153911025 @default.
• W2129005313 hasConcept C2777763344 @default.
• W2129005313 hasConcept C2778635478 @default.
• W2129005313 hasConcept C2779787849 @default.
• W2129005313 hasConcept C553450214 @default.
• W2129005313 hasConcept C55493867 @default.
• W2129005313 hasConcept C86803240 @default.
• W2129005313 hasConcept C89423630 @default.
• W2129005313 hasConceptScore W2129005313C104317684 @default.
• W2129005313 hasConceptScore W2129005313C107538193 @default.
• W2129005313 hasConceptScore W2129005313C127716648 @default.
• W2129005313 hasConceptScore W2129005313C143065580 @default.
• W2129005313 hasConceptScore W2129005313C153911025 @default.
• W2129005313 hasConceptScore W2129005313C2777763344 @default.
• W2129005313 hasConceptScore W2129005313C2778635478 @default.

• next