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• W2129011724 abstract "Transforming growth factor (TGF)β is most commonly considered an anti-inflammatory cytokine, a view that clearly does not correlate with the recently described role for TGFβ1 in the differentiation of T-helper (Th)17 cells, a novel, highly inflammatory T-cell subset that produces interleukin (IL)-17. However, these recent findings endorse earlier studies, pre-dating the discovery of Th17 cells, which described a seemingly paradoxical pro-inflammatory role of TGFβ. In this article, we propose that the administration of neutralizing anti-TGFβ antibodies in target sites of chronic inflammation would ameliorate or abolish disease because this would limit the differentiation of Th17 cells. By contrast, similar interventions at mucosal sites, where Th17 cells seem to have a protective role, might exacerbate disease in experimental models of colitis. An excess production of Th17 cells in response to infection or trauma could result in leakage into peripheral tissues and cause autoimmune pathology. Transforming growth factor (TGF)β is most commonly considered an anti-inflammatory cytokine, a view that clearly does not correlate with the recently described role for TGFβ1 in the differentiation of T-helper (Th)17 cells, a novel, highly inflammatory T-cell subset that produces interleukin (IL)-17. However, these recent findings endorse earlier studies, pre-dating the discovery of Th17 cells, which described a seemingly paradoxical pro-inflammatory role of TGFβ. In this article, we propose that the administration of neutralizing anti-TGFβ antibodies in target sites of chronic inflammation would ameliorate or abolish disease because this would limit the differentiation of Th17 cells. By contrast, similar interventions at mucosal sites, where Th17 cells seem to have a protective role, might exacerbate disease in experimental models of colitis. An excess production of Th17 cells in response to infection or trauma could result in leakage into peripheral tissues and cause autoimmune pathology." @default.
• W2129011724 created "2016-06-24" @default.
• W2129011724 creator A5059045389 @default.
• W2129011724 creator A5078799040 @default.
• W2129011724 date "2006-08-01" @default.
• W2129011724 modified "2023-10-17" @default.
• W2129011724 title "TGFβ1, a ‘Jack of all trades’: the link with pro-inflammatory IL-17-producing T cells" @default.
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• W2129011724 doi "https://doi.org/10.1016/j.it.2006.06.001" @default.
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