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• W2129013826 abstract "Light information is sorted by neuronal circuits to generate image-forming (IF) (interpretation and tracking of visual objects and patterns) and non-image-forming (NIF) tasks. Among the NIF tasks, photic entrainment of circadian rhythms, the pupillary light reflex, and sleep are all associated with physiological responses, mediated mainly by a small group of melanopsin-expressing retinal ganglion cells (mRGCs). Using Xenopus laevis as a model system, and analyzing the c-fos expression induced by light as a surrogate marker of neural activity, we aimed to establish the developmental time at which the cells participating in both systems come on-line in the retina. We found that the peripheral retina contains 80% of the two melanopsin-expressing cell types we identified in Xenopus: melanopsin-expressing horizontal cells (mHCs; opn4m+/opn4x+/Prox1+) and mRGCs (2.7% of the total RGCs; opn4m+/opn4x+/Pax6+/Isl1), in a ratio of 6:1. Only mRGCs induced c-fos expression in response to light. Dopaminergic (tyrosine hydroxylase-positive; TH+) amacrine cells (ACs) may be part of the melanopsin-mediated circuit, as shown by preferential c-fos induction by blue light. In the central retina, two cell types in the inner nuclear layer (INL) showed light-mediated induction of c-fos expression [(On-bipolar cells (Otx2+/Isl1+), and a sub-population of ACs (Pax6−/Isl1−)], as well as two RGC sub-populations (Isl1+/Pax6+ and Isl1+/Pax6−). Melanopsin and opsin expression turned on a day before the point at which c-fos expression could first be activated by light (Stage 37/38), in cells of both the classic vision circuit, and those that participate in the retinal component of the NIF circuit. Key to the classic vision circuit is that the component cells engage from the beginning as functional ‘unit circuits’ of two to three cells in the INL for every RGC, with subsequent growth of the vision circuit occurring by the wiring in of more units. We identified melanopsin-expressing cells and specific cell types in the INL and the RGC layer which induce c-fos expression in response to light, and we determined the developmental time when they become active. We suggest an initial formulation of retinal circuits corresponding to the classic vision pathway and melanopsin-mediated circuits to which they may contribute." @default.
• W2129013826 created "2016-06-24" @default.
• W2129013826 creator A5009144965 @default.
• W2129013826 creator A5039965337 @default.
• W2129013826 creator A5054728483 @default.
• W2129013826 date "2014-02-13" @default.
• W2129013826 modified "2023-10-18" @default.
• W2129013826 title "Wiring the retinal circuits activated by light during early development" @default.
• W2129013826 cites W1479926654 @default.
• W2129013826 cites W1485712002 @default.
• W2129013826 cites W1498038217 @default.
• W2129013826 cites W1504119960 @default.
• W2129013826 cites W1945137855 @default.
• W2129013826 cites W1965921455 @default.
• W2129013826 cites W1970149518 @default.
• W2129013826 cites W1971524741 @default.
• W2129013826 cites W1975389085 @default.
• W2129013826 cites W1975477048 @default.
• W2129013826 cites W1984116068 @default.
• W2129013826 cites W1985094683 @default.
• W2129013826 cites W1989665437 @default.
• W2129013826 cites W1991436519 @default.
• W2129013826 cites W1994112912 @default.
• W2129013826 cites W2004969297 @default.
• W2129013826 cites W2011391168 @default.
• W2129013826 cites W2012437705 @default.
• W2129013826 cites W2018699356 @default.
• W2129013826 cites W2019270121 @default.
• W2129013826 cites W2019663035 @default.
• W2129013826 cites W2019712448 @default.
• W2129013826 cites W2024490391 @default.
• W2129013826 cites W2035853180 @default.
• W2129013826 cites W2036239753 @default.
• W2129013826 cites W2038769472 @default.
• W2129013826 cites W2038892197 @default.
• W2129013826 cites W2040941220 @default.
• W2129013826 cites W2041245092 @default.
• W2129013826 cites W2046051665 @default.
• W2129013826 cites W2049690253 @default.
• W2129013826 cites W2052588363 @default.
• W2129013826 cites W2053953105 @default.
• W2129013826 cites W2054617306 @default.
• W2129013826 cites W2056888759 @default.
• W2129013826 cites W2061911673 @default.
• W2129013826 cites W2062411733 @default.
• W2129013826 cites W2063091716 @default.
• W2129013826 cites W2063183740 @default.
• W2129013826 cites W2066953605 @default.
• W2129013826 cites W2070154168 @default.
• W2129013826 cites W2075158314 @default.
• W2129013826 cites W2075644551 @default.
• W2129013826 cites W2076727881 @default.
• W2129013826 cites W2081957674 @default.
• W2129013826 cites W2084081857 @default.
• W2129013826 cites W2087448663 @default.
• W2129013826 cites W2092245700 @default.
• W2129013826 cites W2092510003 @default.
• W2129013826 cites W2094409021 @default.
• W2129013826 cites W2096517177 @default.
• W2129013826 cites W2098702533 @default.
• W2129013826 cites W2104809074 @default.
• W2129013826 cites W2105050095 @default.
• W2129013826 cites W2110209988 @default.
• W2129013826 cites W2115675288 @default.
• W2129013826 cites W2116156647 @default.
• W2129013826 cites W2116665706 @default.
• W2129013826 cites W2117112829 @default.
• W2129013826 cites W2119629566 @default.
• W2129013826 cites W2124224192 @default.
• W2129013826 cites W2126432711 @default.
• W2129013826 cites W2128754473 @default.
• W2129013826 cites W2131322538 @default.
• W2129013826 cites W2131810280 @default.
• W2129013826 cites W2138995901 @default.
• W2129013826 cites W2143502943 @default.
• W2129013826 cites W2148728346 @default.
• W2129013826 cites W2153736551 @default.
• W2129013826 cites W2157883603 @default.
• W2129013826 cites W2165755710 @default.
• W2129013826 cites W2405024622 @default.
• W2129013826 cites W4293241459 @default.
• W2129013826 cites W584631269 @default.
• W2129013826 doi "https://doi.org/10.1186/1749-8104-9-3" @default.
• W2129013826 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3937046" @default.
• W2129013826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24521229" @default.
• W2129013826 hasPublicationYear "2014" @default.
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• W2129013826 hasAuthorship W2129013826A5009144965 @default.
• W2129013826 hasAuthorship W2129013826A5039965337 @default.
• W2129013826 hasAuthorship W2129013826A5054728483 @default.

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