FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129042078> ?p ?o ?g. }

• W2129042078 endingPage "9" @default.
• W2129042078 startingPage "1" @default.
• W2129042078 abstract "Enzymes of the cytochrome P450 superfamily play a key role in xenobiotic metabolism. Their properties and significance are discussed with particular reference to interactions with the H+, K+-ATPase blocker, omeprazole. Such interactions include both inhibitory (subfamily 2C) and inducing effects (subfamily 1A). Delayed metabolic elimination of diazepam, warfarin, carbamazepin and phenytoin is probably due to omeprazole competition for the concerned isoform of subfamily 2C; however, these effects are modest to negligible in magnitude and, for phenytoin, not consistently reproducible. Also, induction of subfamily 1A is only minor as assessed from the resultant changes in N-3-demethylation of caffeine, a reaction specific to this subfamily. Concerns about a possible activation of procarcinogens that might arise from subfamily 1A induction appear ill-founded given the fact that cruciferous vegetables such as broccoli and Brussels sprouts are potent inducers, but rather seem to lower the incidence of certain types of cancer. Likewise, the idea that the toxicity of acetaminophen might increase upon subfamily 1A induction appears far-fetched, mainly because much stronger inducers of subfamily 1A (cigarette smoke and charcoaled beef) are unable to alter acetaminophen metabolism." @default.
• W2129042078 created "2016-06-24" @default.
• W2129042078 creator A5074837805 @default.
• W2129042078 date "2007-03-31" @default.
• W2129042078 modified "2023-09-23" @default.
• W2129042078 title "Omeprazole and the cytochrome P450 system" @default.
• W2129042078 cites W1004452157 @default.
• W2129042078 cites W145252432 @default.
• W2129042078 cites W1543075972 @default.
• W2129042078 cites W1566599147 @default.
• W2129042078 cites W1570746601 @default.
• W2129042078 cites W1646230736 @default.
• W2129042078 cites W1650427240 @default.
• W2129042078 cites W1690918147 @default.
• W2129042078 cites W1745191739 @default.
• W2129042078 cites W1866176581 @default.
• W2129042078 cites W1919719843 @default.
• W2129042078 cites W1963957404 @default.
• W2129042078 cites W1965196372 @default.
• W2129042078 cites W1967456965 @default.
• W2129042078 cites W1972053711 @default.
• W2129042078 cites W1973751472 @default.
• W2129042078 cites W1975242893 @default.
• W2129042078 cites W1987732730 @default.
• W2129042078 cites W1988368981 @default.
• W2129042078 cites W1994770347 @default.
• W2129042078 cites W1998573208 @default.
• W2129042078 cites W2000022226 @default.
• W2129042078 cites W2002749790 @default.
• W2129042078 cites W2004390239 @default.
• W2129042078 cites W2008146007 @default.
• W2129042078 cites W2012528683 @default.
• W2129042078 cites W2016174453 @default.
• W2129042078 cites W2019314445 @default.
• W2129042078 cites W2021565085 @default.
• W2129042078 cites W2023977295 @default.
• W2129042078 cites W2024370755 @default.
• W2129042078 cites W2024587809 @default.
• W2129042078 cites W2031044965 @default.
• W2129042078 cites W2033564508 @default.
• W2129042078 cites W2037183038 @default.
• W2129042078 cites W2038110081 @default.
• W2129042078 cites W2039647112 @default.
• W2129042078 cites W2041779532 @default.
• W2129042078 cites W2045981977 @default.
• W2129042078 cites W2047895356 @default.
• W2129042078 cites W2051951493 @default.
• W2129042078 cites W2057734524 @default.
• W2129042078 cites W2064789316 @default.
• W2129042078 cites W2065976317 @default.
• W2129042078 cites W2066681384 @default.
• W2129042078 cites W2067690667 @default.
• W2129042078 cites W2072682236 @default.
• W2129042078 cites W2072752945 @default.
• W2129042078 cites W2076623243 @default.
• W2129042078 cites W2078732261 @default.
• W2129042078 cites W2079368823 @default.
• W2129042078 cites W2081395866 @default.
• W2129042078 cites W2088342692 @default.
• W2129042078 cites W2088524561 @default.
• W2129042078 cites W2088837725 @default.
• W2129042078 cites W2090603119 @default.
• W2129042078 cites W2091841299 @default.
• W2129042078 cites W2092116907 @default.
• W2129042078 cites W2093040718 @default.
• W2129042078 cites W2094302485 @default.
• W2129042078 cites W2098802759 @default.
• W2129042078 cites W2111001121 @default.
• W2129042078 cites W2124622604 @default.
• W2129042078 cites W2150946709 @default.
• W2129042078 cites W2234435485 @default.
• W2129042078 cites W2242310113 @default.
• W2129042078 cites W2336749186 @default.
• W2129042078 cites W2410785625 @default.
• W2129042078 cites W2613909197 @default.
• W2129042078 cites W2801904289 @default.
• W2129042078 cites W2955831827 @default.
• W2129042078 cites W3175532480 @default.
• W2129042078 doi "https://doi.org/10.1111/j.1365-2036.1995.tb00344.x" @default.
• W2129042078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7766737" @default.
• W2129042078 hasPublicationYear "2007" @default.
• W2129042078 type Work @default.
• W2129042078 sameAs 2129042078 @default.
• W2129042078 citedByCount "26" @default.
• W2129042078 countsByYear W21290420782012 @default.
• W2129042078 countsByYear W21290420782013 @default.
• W2129042078 countsByYear W21290420782021 @default.
• W2129042078 crossrefType "journal-article" @default.
• W2129042078 hasAuthorship W2129042078A5074837805 @default.
• W2129042078 hasConcept C104317684 @default.
• W2129042078 hasConcept C132154277 @default.
• W2129042078 hasConcept C181199279 @default.
• W2129042078 hasConcept C185592680 @default.
• W2129042078 hasConcept C2777498785 @default.
• W2129042078 hasConcept C50929876 @default.
• W2129042078 hasConcept C526171541 @default.
• W2129042078 hasConcept C55493867 @default.
• W2129042078 hasConcept C62231903 @default.

• next