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• W2129044093 abstract "In this review article we have reported a series of hybrid compounds characterized by the presence of a α- halogenocryloyl alkylating moiety of low chemical reactivity, linked to known antitumor agents or their active moieties. Among them, brostallicin (PNU-166196), was selected for clinical development and is now undergoing Phase II studies in patients with advanced or metastatic soft tissue sarcoma. Keywords: Antitumor agents, Distamycin A, apoptosis, α-bromoacryloyl, hybrid molecules" @default.
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• W2129044093 date "2009-01-01" @default.
• W2129044093 modified "2023-10-18" @default.
• W2129044093 title "&#945;-Halogenoacrylic Derivatives of Antitumor Agents" @default.
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• W2129044093 doi "https://doi.org/10.2174/138955709787001640" @default.
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