FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129052470> ?p ?o ?g. }

• W2129052470 endingPage "4608" @default.
• W2129052470 startingPage "4599" @default.
• W2129052470 abstract "Peptide growth factors have been implicated in progression of prostate cancer (PCa) to the androgen-independent state; however, much of the evidence linking diffusible mitogens and survival factors to this process remains circumstantial. Heparin-binding epidermal growth factor-like growth factor (HB-EGF), a prostate stroma-derived factor, promotes survival, proliferation, and neuroendocrine differentiation of androgen-dependent LNCaP PCa cells in vitro. To test whether sustained exposure to HB-EGF can confer an androgen-independent phenotype, we generated stable populations of LNCaP cells that express constitutively a secreted form of HB-EGF (LNCaP/sHB). LNCaP/sHB cells proliferated more rapidly under androgen-depleted conditions in vitro and formed larger tumors with higher frequency in intact and castrated severe combined immunodeficient mice, in comparison to control cells. LNCaP/sHB tumors also expressed higher levels of the neuroendocrine marker, neuron-specific enolase, compared with control tumors. In castrates, increased neuron-specific enolase expression in LNCaP/sHB tumors was associated with reduced androgen receptor (AR) levels. In vitro, AR protein levels were reduced in LNCaP/sHB cells, and in transient transfection assays using an androgen-responsive promoter (mouse mammary tumor virus-long terminal repeat), LNCaP/sHB cells showed reduced sensitivity to dihydrotestosterone compared with controls. This is the first demonstration that continuous exposure of AR-positive PCa cells to a single growth factor can promote an androgen-independent phenotype in vivo. These findings also emphasize the potential role of pathways other than the AR axis in acquisition of androgen independence." @default.
• W2129052470 created "2016-06-24" @default.
• W2129052470 creator A5006714419 @default.
• W2129052470 creator A5013309259 @default.
• W2129052470 creator A5016079399 @default.
• W2129052470 creator A5058352236 @default.
• W2129052470 creator A5066831325 @default.
• W2129052470 creator A5069789939 @default.
• W2129052470 creator A5070472491 @default.
• W2129052470 date "2002-12-01" @default.
• W2129052470 modified "2023-09-30" @default.
• W2129052470 title "Heparin-Binding Epidermal Growth Factor-Like Growth Factor Stimulates Androgen-Independent Prostate Tumor Growth and Antagonizes Androgen Receptor Function" @default.
• W2129052470 cites W1567894855 @default.
• W2129052470 cites W1580523172 @default.
• W2129052470 cites W1964404787 @default.
• W2129052470 cites W1976491226 @default.
• W2129052470 cites W1981797774 @default.
• W2129052470 cites W198343785 @default.
• W2129052470 cites W1985827132 @default.
• W2129052470 cites W1988679331 @default.
• W2129052470 cites W1999837736 @default.
• W2129052470 cites W2005287015 @default.
• W2129052470 cites W2005658600 @default.
• W2129052470 cites W2007845017 @default.
• W2129052470 cites W2008498145 @default.
• W2129052470 cites W2012104993 @default.
• W2129052470 cites W2013167803 @default.
• W2129052470 cites W2018619066 @default.
• W2129052470 cites W2020636054 @default.
• W2129052470 cites W2030819637 @default.
• W2129052470 cites W2032593619 @default.
• W2129052470 cites W2041170984 @default.
• W2129052470 cites W2043236550 @default.
• W2129052470 cites W2043631674 @default.
• W2129052470 cites W2050846683 @default.
• W2129052470 cites W2061466636 @default.
• W2129052470 cites W2061686178 @default.
• W2129052470 cites W2061908536 @default.
• W2129052470 cites W2063116472 @default.
• W2129052470 cites W2066570340 @default.
• W2129052470 cites W2071347266 @default.
• W2129052470 cites W2079486536 @default.
• W2129052470 cites W2083876618 @default.
• W2129052470 cites W2084260624 @default.
• W2129052470 cites W2095634621 @default.
• W2129052470 cites W2103177037 @default.
• W2129052470 cites W2110669077 @default.
• W2129052470 cites W2114693836 @default.
• W2129052470 cites W2129129118 @default.
• W2129052470 cites W2153354003 @default.
• W2129052470 cites W4254037116 @default.
• W2129052470 cites W4376545141 @default.
• W2129052470 cites W2006079245 @default.
• W2129052470 doi "https://doi.org/10.1210/en.2002-220561" @default.
• W2129052470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12446587" @default.
• W2129052470 hasPublicationYear "2002" @default.
• W2129052470 type Work @default.
• W2129052470 sameAs 2129052470 @default.
• W2129052470 citedByCount "54" @default.
• W2129052470 countsByYear W21290524702012 @default.
• W2129052470 countsByYear W21290524702013 @default.
• W2129052470 countsByYear W21290524702014 @default.
• W2129052470 countsByYear W21290524702015 @default.
• W2129052470 countsByYear W21290524702018 @default.
• W2129052470 countsByYear W21290524702021 @default.
• W2129052470 crossrefType "journal-article" @default.
• W2129052470 hasAuthorship W2129052470A5006714419 @default.
• W2129052470 hasAuthorship W2129052470A5013309259 @default.
• W2129052470 hasAuthorship W2129052470A5016079399 @default.
• W2129052470 hasAuthorship W2129052470A5058352236 @default.
• W2129052470 hasAuthorship W2129052470A5066831325 @default.
• W2129052470 hasAuthorship W2129052470A5069789939 @default.
• W2129052470 hasAuthorship W2129052470A5070472491 @default.
• W2129052470 hasBestOaLocation W21290524701 @default.
• W2129052470 hasConcept C121608353 @default.
• W2129052470 hasConcept C126322002 @default.
• W2129052470 hasConcept C134018914 @default.
• W2129052470 hasConcept C170493617 @default.
• W2129052470 hasConcept C2775960820 @default.
• W2129052470 hasConcept C2776362946 @default.
• W2129052470 hasConcept C2777911890 @default.
• W2129052470 hasConcept C2779723316 @default.
• W2129052470 hasConcept C2779881493 @default.
• W2129052470 hasConcept C2780192828 @default.
• W2129052470 hasConcept C2780341458 @default.
• W2129052470 hasConcept C502942594 @default.
• W2129052470 hasConcept C61367390 @default.
• W2129052470 hasConcept C71315377 @default.
• W2129052470 hasConcept C71924100 @default.
• W2129052470 hasConcept C86803240 @default.
• W2129052470 hasConceptScore W2129052470C121608353 @default.
• W2129052470 hasConceptScore W2129052470C126322002 @default.
• W2129052470 hasConceptScore W2129052470C134018914 @default.
• W2129052470 hasConceptScore W2129052470C170493617 @default.
• W2129052470 hasConceptScore W2129052470C2775960820 @default.
• W2129052470 hasConceptScore W2129052470C2776362946 @default.
• W2129052470 hasConceptScore W2129052470C2777911890 @default.
• W2129052470 hasConceptScore W2129052470C2779723316 @default.

• next