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• W2129064912 abstract "The interrelationship between the ability to inhibit incoming redundant input (gating out) and the ability of the brain to respond when the stimulus changes (gating in), has not been extensively examined. We administered a battery of auditory evoked potential tests to a group of chronic, medicated schizophrenia patients (N=12) and a group of healthy subjects (N=12) in order to examine relationships between gating out measures (suppression with repetition of the P50, N100, and P200 evoked responses), and the mismatch negativity (MMN) and the P300 event related potentials as measures of gating in. Gating ratios for N100 and P200 in a visual attention paired-click task differed significantly between groups. Mismatch negativity and P300 potential amplitudes were also significantly reduced in the patient group. When including all subjects (N=24) a negative correlation was found between the P50 gating and the amplitude of the MMN. In healthy subjects this correlation was significantly stronger compared to schizophrenia patients. While no significant correlation was noted between the amplitudes of the P300 and any gating measures when all 24 subjects were included, a significant negative correlation was seen between the P200 gating and the P300 amplitudes in schizophrenia patients; an opposite trend was noted in healthy subjects. Finally, a positive correlation was seen between the P300 and MMN (to abstract deviance) amplitudes in healthy subjects, but the opposite was found in patients. These results suggest that further study of these interrelationships could inform the understanding of information processing abnormalities in schizophrenia." @default.
• W2129064912 created "2016-06-24" @default.
• W2129064912 creator A5007426801 @default.
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• W2129064912 date "2010-08-01" @default.
• W2129064912 modified "2023-09-26" @default.
• W2129064912 title "Relationships between sensory “gating out” and sensory “gating in” of auditory evoked potentials in schizophrenia: A pilot study" @default.
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• W2129064912 doi "https://doi.org/10.1016/j.schres.2010.04.020" @default.
• W2129064912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2910174" @default.
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