FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129082503> ?p ?o ?g. }

• W2129082503 endingPage "38" @default.
• W2129082503 startingPage "38" @default.
• W2129082503 abstract "In folklore, some people take the decoction of Calyx seu Fructus Physalis (CSFP) for lowering blood lipids. The present study is designed to evaluate the lipid-lowering activities of CSFP, and search for its pharmacodynamical material. CSFP was extracted by water and 75% ethanol, respectively. The extracts of CSFP for reducing serum lipid levels were evaluated on mouse model of hyperlipidemia. The optimized extract was subjected to the bioactivity-guided fractionation in which the liquid-liquid extraction, collumn chromatography, the in vivo and in vitro models of hyperlipidemia were utilized. The structure of active component was determined by 13 C-NMR and 1H-NMR. The 75% ethanol extract of CSFP decreased the serum total cholesterol (TC) and triglyceride (TG) levels in mouse model of hyperlipidemia. Followed a separation process for the 75% ethanol extract of CSFP, the fraction B was proved to be an active fraction for lowering lipid in vivo and in vitro experiments, which could significantly decrease the serum TC and TG levels in mouse model of hyperlipidemia, and remarkably decrease the increase of TG in primary mouse hepatocytes induced by high glucose and the increase of TG in HepG2 cells induced by oleic acid. The fraction B2, isolated from B on bioactivity-guided fractionation, could significantly decrease TG level in HepG2 cells. One compound with the highest content in B2 was isolated and determined as luteolin-7-O-beta-D-glucopyranoside by NMR spectra. It could significantly reduce the TG level in HepG2 cells, and inhibited the accumulation of lipids by oil red O stain. Our results demonstrated that the 75% ethanol extract of CSFP could improve in vitro and in vivo lipid accumulation. Luteolin-7-O-beta-D-glucopyranoside might be a leading pharmacodynamical material of CSFP for lowering lipids." @default.
• W2129082503 created "2016-06-24" @default.
• W2129082503 creator A5019873683 @default.
• W2129082503 creator A5023022658 @default.
• W2129082503 creator A5031312205 @default.
• W2129082503 creator A5031427950 @default.
• W2129082503 creator A5040834612 @default.
• W2129082503 creator A5048205844 @default.
• W2129082503 creator A5048440698 @default.
• W2129082503 creator A5070787203 @default.
• W2129082503 creator A5085859464 @default.
• W2129082503 creator A5088568218 @default.
• W2129082503 date "2012-01-01" @default.
• W2129082503 modified "2023-09-25" @default.
• W2129082503 title "Bioactivity-guided fractionation of the triglyceride-lowering component and in vivo and in vitro evaluation of hypolipidemic effects of Calyx seu Fructus Physalis" @default.
• W2129082503 cites W1966644890 @default.
• W2129082503 cites W1990133507 @default.
• W2129082503 cites W2002598396 @default.
• W2129082503 cites W2013075710 @default.
• W2129082503 cites W2044983083 @default.
• W2129082503 cites W2048056811 @default.
• W2129082503 cites W2076001331 @default.
• W2129082503 cites W2085277898 @default.
• W2129082503 cites W2108889231 @default.
• W2129082503 cites W2117274684 @default.
• W2129082503 cites W2118649023 @default.
• W2129082503 cites W2122618248 @default.
• W2129082503 cites W2132279891 @default.
• W2129082503 cites W2166910397 @default.
• W2129082503 doi "https://doi.org/10.1186/1476-511x-11-38" @default.
• W2129082503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3338407" @default.
• W2129082503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22413998" @default.
• W2129082503 hasPublicationYear "2012" @default.
• W2129082503 type Work @default.
• W2129082503 sameAs 2129082503 @default.
• W2129082503 citedByCount "11" @default.
• W2129082503 countsByYear W21290825032012 @default.
• W2129082503 countsByYear W21290825032014 @default.
• W2129082503 countsByYear W21290825032015 @default.
• W2129082503 countsByYear W21290825032018 @default.
• W2129082503 countsByYear W21290825032019 @default.
• W2129082503 countsByYear W21290825032022 @default.
• W2129082503 countsByYear W21290825032023 @default.
• W2129082503 crossrefType "journal-article" @default.
• W2129082503 hasAuthorship W2129082503A5019873683 @default.
• W2129082503 hasAuthorship W2129082503A5023022658 @default.
• W2129082503 hasAuthorship W2129082503A5031312205 @default.
• W2129082503 hasAuthorship W2129082503A5031427950 @default.
• W2129082503 hasAuthorship W2129082503A5040834612 @default.
• W2129082503 hasAuthorship W2129082503A5048205844 @default.
• W2129082503 hasAuthorship W2129082503A5048440698 @default.
• W2129082503 hasAuthorship W2129082503A5070787203 @default.
• W2129082503 hasAuthorship W2129082503A5085859464 @default.
• W2129082503 hasAuthorship W2129082503A5088568218 @default.
• W2129082503 hasBestOaLocation W21290825031 @default.
• W2129082503 hasConcept C134018914 @default.
• W2129082503 hasConcept C150903083 @default.
• W2129082503 hasConcept C185592680 @default.
• W2129082503 hasConcept C202751555 @default.
• W2129082503 hasConcept C207001950 @default.
• W2129082503 hasConcept C2778163477 @default.
• W2129082503 hasConcept C2778913445 @default.
• W2129082503 hasConcept C2779091943 @default.
• W2129082503 hasConcept C2780161600 @default.
• W2129082503 hasConcept C382228 @default.
• W2129082503 hasConcept C43617362 @default.
• W2129082503 hasConcept C55493867 @default.
• W2129082503 hasConcept C555293320 @default.
• W2129082503 hasConcept C86803240 @default.
• W2129082503 hasConcept C97428945 @default.
• W2129082503 hasConcept C98274493 @default.
• W2129082503 hasConceptScore W2129082503C134018914 @default.
• W2129082503 hasConceptScore W2129082503C150903083 @default.
• W2129082503 hasConceptScore W2129082503C185592680 @default.
• W2129082503 hasConceptScore W2129082503C202751555 @default.
• W2129082503 hasConceptScore W2129082503C207001950 @default.
• W2129082503 hasConceptScore W2129082503C2778163477 @default.
• W2129082503 hasConceptScore W2129082503C2778913445 @default.
• W2129082503 hasConceptScore W2129082503C2779091943 @default.
• W2129082503 hasConceptScore W2129082503C2780161600 @default.
• W2129082503 hasConceptScore W2129082503C382228 @default.
• W2129082503 hasConceptScore W2129082503C43617362 @default.
• W2129082503 hasConceptScore W2129082503C55493867 @default.
• W2129082503 hasConceptScore W2129082503C555293320 @default.
• W2129082503 hasConceptScore W2129082503C86803240 @default.
• W2129082503 hasConceptScore W2129082503C97428945 @default.
• W2129082503 hasConceptScore W2129082503C98274493 @default.
• W2129082503 hasIssue "1" @default.
• W2129082503 hasLocation W21290825031 @default.
• W2129082503 hasLocation W21290825032 @default.
• W2129082503 hasLocation W21290825033 @default.
• W2129082503 hasLocation W21290825034 @default.
• W2129082503 hasOpenAccess W2129082503 @default.
• W2129082503 hasPrimaryLocation W21290825031 @default.
• W2129082503 hasRelatedWork W1965259207 @default.
• W2129082503 hasRelatedWork W1965892274 @default.
• W2129082503 hasRelatedWork W2062881029 @default.
• W2129082503 hasRelatedWork W2067898441 @default.

• next