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• W2129082893 abstract "In an era of increasing resistance to classical antibacterial agents, the synthetic oxazolidinone series of antibiotics has attracted much interest. Zyvox™ was the first oxazolidinone to be approved for clinical use against infections caused by multi-drug resistant Gram-positive bacteria. In the course of studies directed toward the discovery of novel antibacterial agents, a new series of synthetic phenyl-isoxazolinone agents that displayed potent activity against Gram-positive bacterial strains was recently discovered at Bristol-Myers Squibb. Extensive investigation of various substitutions on the phenyl ring was then undertaken. We report here, the synthesis and antibacterial activity of a series of biaryl isoxazolinone compounds." @default.
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• W2129082893 date "2005-06-01" @default.
• W2129082893 modified "2023-09-27" @default.
• W2129082893 title "Biaryl isoxazolinone antibacterial agents" @default.
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• W2129082893 doi "https://doi.org/10.1016/j.bmcl.2005.04.003" @default.
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