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- W2129091609 abstract "Cutaneous melanomas are notorious for their tendency to metastasise. Because the tumour microenvironment plays an important part in tumour development and progression, we review the structural and functional aspects of interactions between melanoma and the stroma. We emphasise fibrovascular patterns (both in uveal and cutaneous melanoma), cellular and extracellular composition of the stroma, and the molecules involved. Also, we discuss functional interactions, focusing on melanoma-fibroblast cross-talk by soluble factors and by direct cell-cell contact. On the basis of recent findings we propose that involvement of fibroblasts in melanoma-stromagenesis occurs through different stages: recruitment, activation, and conversion to myofibroblasts, or differentiation to fibrocytes. We reason that this involvement is topographically linked to different areas in and around the tumour, and hypothesise that stromal activation, as seen in tumor ulceration or immunological regression in melanoma, stimulates tumour progression." @default.
- W2129091609 created "2016-06-24" @default.
- W2129091609 creator A5004480921 @default.
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- W2129091609 date "2002-01-01" @default.
- W2129091609 modified "2023-09-24" @default.
- W2129091609 title "Melanoma–stroma interactions: structural and functional aspects" @default.
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- W2129091609 doi "https://doi.org/10.1016/s1470-2045(01)00620-9" @default.
- W2129091609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11905603" @default.
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