FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129100727> ?p ?o ?g. }

• W2129100727 endingPage "2955" @default.
• W2129100727 startingPage "2946" @default.
• W2129100727 abstract "Objective— To study the interactions of cytoplasmic calcium elevation, mitochondrial permeability transition pore (mPTP) formation, and reactive oxygen species formation in the regulation of phosphatidylserine (PS) exposure in platelets. Methods and Results— mPTP formation, but not the degree of cytoplasmic calcium elevation, was associated with PS exposure in wild-type, cyclophilin D–null, ionomycin-treated, and reactive oxygen species–treated platelets. In the absence of the mPTP regulator cyclophilin D, agonist-initiated mPTP formation and high-level PS exposure were markedly blunted, but cytoplasmic calcium transients were unchanged. Mitochondrial calcium (Ca 2+ mit ) transients and reactive oxygen species, key regulators of mPTP formation, were examined in strongly stimulated platelets. Increased reactive oxygen species production occurred in strongly stimulated platelets and was dependent on extracellular calcium entry, but not the presence of cyclophilin D. Ca 2+ mit increased significantly in strongly stimulated platelets. Abrogation of Ca 2+ mit entry, either by inhibition of the Ca 2+ mit uniporter or mitochondrial depolarization, prevented mPTP formation and exposure but not platelet aggregation or granule release. Conclusion— Sustained cytoplasmic calcium levels are necessary, but not sufficient, for high-level PS exposure in response to agonists. Increased Ca 2+ mit levels are a key signal initiating mPTP formation and PS exposure. Blockade of Ca 2+ mit entry allows the specific inhibition of platelet procoagulant activity." @default.
• W2129100727 created "2016-06-24" @default.
• W2129100727 creator A5052112034 @default.
• W2129100727 creator A5053372224 @default.
• W2129100727 creator A5054004945 @default.
• W2129100727 creator A5055624506 @default.
• W2129100727 creator A5058057464 @default.
• W2129100727 date "2012-12-01" @default.
• W2129100727 modified "2023-10-16" @default.
• W2129100727 title "Mitochondrial Calcium and Reactive Oxygen Species Regulate Agonist-Initiated Platelet Phosphatidylserine Exposure" @default.
• W2129100727 cites W119409406 @default.
• W2129100727 cites W1857730116 @default.
• W2129100727 cites W1965361683 @default.
• W2129100727 cites W1968188734 @default.
• W2129100727 cites W1971608015 @default.
• W2129100727 cites W1980959570 @default.
• W2129100727 cites W1983721382 @default.
• W2129100727 cites W1986213783 @default.
• W2129100727 cites W1995069275 @default.
• W2129100727 cites W2000123239 @default.
• W2129100727 cites W2001685322 @default.
• W2129100727 cites W2006015927 @default.
• W2129100727 cites W2007681373 @default.
• W2129100727 cites W2015871595 @default.
• W2129100727 cites W2022645745 @default.
• W2129100727 cites W2023605251 @default.
• W2129100727 cites W2039640090 @default.
• W2129100727 cites W2042103200 @default.
• W2129100727 cites W2047758994 @default.
• W2129100727 cites W2048993292 @default.
• W2129100727 cites W2050808293 @default.
• W2129100727 cites W2063099262 @default.
• W2129100727 cites W2064465533 @default.
• W2129100727 cites W2066198761 @default.
• W2129100727 cites W2067841051 @default.
• W2129100727 cites W2069047064 @default.
• W2129100727 cites W2074800090 @default.
• W2129100727 cites W2075872808 @default.
• W2129100727 cites W2086589360 @default.
• W2129100727 cites W2089663038 @default.
• W2129100727 cites W2092510248 @default.
• W2129100727 cites W2095049732 @default.
• W2129100727 cites W2096321546 @default.
• W2129100727 cites W2101787993 @default.
• W2129100727 cites W2111501638 @default.
• W2129100727 cites W2122129887 @default.
• W2129100727 cites W2137036914 @default.
• W2129100727 cites W2141088469 @default.
• W2129100727 cites W2148959908 @default.
• W2129100727 cites W2149324458 @default.
• W2129100727 cites W2149396086 @default.
• W2129100727 cites W2162292125 @default.
• W2129100727 cites W2166209270 @default.
• W2129100727 cites W2167248515 @default.
• W2129100727 cites W2171154502 @default.
• W2129100727 cites W2172102724 @default.
• W2129100727 cites W2409501971 @default.
• W2129100727 cites W4243240123 @default.
• W2129100727 cites W4250858171 @default.
• W2129100727 doi "https://doi.org/10.1161/atvbaha.112.300433" @default.
• W2129100727 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3545632" @default.
• W2129100727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23087357" @default.
• W2129100727 hasPublicationYear "2012" @default.
• W2129100727 type Work @default.
• W2129100727 sameAs 2129100727 @default.
• W2129100727 citedByCount "88" @default.
• W2129100727 countsByYear W21291007272013 @default.
• W2129100727 countsByYear W21291007272014 @default.
• W2129100727 countsByYear W21291007272015 @default.
• W2129100727 countsByYear W21291007272016 @default.
• W2129100727 countsByYear W21291007272017 @default.
• W2129100727 countsByYear W21291007272018 @default.
• W2129100727 countsByYear W21291007272019 @default.
• W2129100727 countsByYear W21291007272020 @default.
• W2129100727 countsByYear W21291007272021 @default.
• W2129100727 countsByYear W21291007272022 @default.
• W2129100727 countsByYear W21291007272023 @default.
• W2129100727 crossrefType "journal-article" @default.
• W2129100727 hasAuthorship W2129100727A5052112034 @default.
• W2129100727 hasAuthorship W2129100727A5053372224 @default.
• W2129100727 hasAuthorship W2129100727A5054004945 @default.
• W2129100727 hasAuthorship W2129100727A5055624506 @default.
• W2129100727 hasAuthorship W2129100727A5058057464 @default.
• W2129100727 hasBestOaLocation W21291007271 @default.
• W2129100727 hasConcept C12554922 @default.
• W2129100727 hasConcept C134018914 @default.
• W2129100727 hasConcept C13591479 @default.
• W2129100727 hasConcept C137183658 @default.
• W2129100727 hasConcept C178790620 @default.
• W2129100727 hasConcept C181199279 @default.
• W2129100727 hasConcept C185592680 @default.
• W2129100727 hasConcept C190283241 @default.
• W2129100727 hasConcept C2776989580 @default.
• W2129100727 hasConcept C2778674702 @default.
• W2129100727 hasConcept C31573885 @default.
• W2129100727 hasConcept C35341161 @default.
• W2129100727 hasConcept C48349386 @default.
• W2129100727 hasConcept C513476851 @default.

• next