Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129119177> ?p ?o ?g. }
- W2129119177 abstract "The syndrome of primary progressive aphasia (PPA) is diagnosed when a gradual failure of word usage or comprehension emerges as the principal feature of a neurodegenerative disease.To provide a quantitative algorithm for classifying PPA into agrammatic (PPA-G), semantic (PPA-S), and logopenic (PPA-L) variants, each of which is known to have a different probability of association with Alzheimer disease vs frontotemporal lobar degeneration.Prospective study.University medical center.Sixteen consecutively enrolled patients with PPA who underwent neuropsychological testing and magnetic resonance imaging recruited nationally in the United States as part of a longitudinal study.A 2-dimensional template that reflects performance on tests of syntax (Northwestern Anagram Test) and lexical semantics (Peabody Picture Vocabulary Test-Fourth Edition) classified all 16 patients in concordance with a clinical diagnosis that had been made before the administration of quantitative tests. All 3 PPA subtypes had distinctly asymmetrical atrophy of the left perisylvian language network. Each subtype also had distinctive peak atrophy sites: PPA-G in the inferior frontal gyrus (Broca area), PPA-S in the anterior temporal lobe, and PPA-L in Brodmann area 37.Once an accurate root diagnosis of PPA is made, subtyping can be quantitatively guided using a 2-dimensional template based on orthogonal tasks of grammatical competence and word comprehension. Although the choice of tasks and the precise cutoff levels may need to be adjusted to fit linguistic and educational backgrounds, these 16 patients demonstrate the feasibility of using a simple algorithm for clinicoanatomical classification in PPA. Prospective studies will show whether this subtyping can improve clinical prediction of the underlying neuropathologic condition." @default.
- W2129119177 created "2016-06-24" @default.
- W2129119177 creator A5002754020 @default.
- W2129119177 creator A5014953513 @default.
- W2129119177 creator A5017437213 @default.
- W2129119177 creator A5059469170 @default.
- W2129119177 creator A5062155936 @default.
- W2129119177 creator A5077854816 @default.
- W2129119177 date "2009-12-01" @default.
- W2129119177 modified "2023-10-12" @default.
- W2129119177 title "Quantitative Template for Subtyping Primary Progressive Aphasia" @default.
- W2129119177 cites W1526181481 @default.
- W2129119177 cites W1958019198 @default.
- W2129119177 cites W1974583546 @default.
- W2129119177 cites W1975043679 @default.
- W2129119177 cites W1989849554 @default.
- W2129119177 cites W2012763181 @default.
- W2129119177 cites W2014161370 @default.
- W2129119177 cites W2026794646 @default.
- W2129119177 cites W2027408391 @default.
- W2129119177 cites W2038130312 @default.
- W2129119177 cites W2067002176 @default.
- W2129119177 cites W2090326437 @default.
- W2129119177 cites W2094206043 @default.
- W2129119177 cites W2103636364 @default.
- W2129119177 cites W2110343198 @default.
- W2129119177 cites W2117232359 @default.
- W2129119177 cites W2135496343 @default.
- W2129119177 cites W2136022845 @default.
- W2129119177 cites W2154633730 @default.
- W2129119177 cites W2158090607 @default.
- W2129119177 cites W2159185009 @default.
- W2129119177 cites W2163212838 @default.
- W2129119177 cites W2163274894 @default.
- W2129119177 cites W2163948863 @default.
- W2129119177 cites W2415859935 @default.
- W2129119177 cites W595210553 @default.
- W2129119177 doi "https://doi.org/10.1001/archneurol.2009.288" @default.
- W2129119177 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2796598" @default.
- W2129119177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20008661" @default.
- W2129119177 hasPublicationYear "2009" @default.
- W2129119177 type Work @default.
- W2129119177 sameAs 2129119177 @default.
- W2129119177 citedByCount "204" @default.
- W2129119177 countsByYear W21291191772012 @default.
- W2129119177 countsByYear W21291191772013 @default.
- W2129119177 countsByYear W21291191772014 @default.
- W2129119177 countsByYear W21291191772015 @default.
- W2129119177 countsByYear W21291191772016 @default.
- W2129119177 countsByYear W21291191772017 @default.
- W2129119177 countsByYear W21291191772018 @default.
- W2129119177 countsByYear W21291191772019 @default.
- W2129119177 countsByYear W21291191772020 @default.
- W2129119177 countsByYear W21291191772021 @default.
- W2129119177 countsByYear W21291191772022 @default.
- W2129119177 countsByYear W21291191772023 @default.
- W2129119177 crossrefType "journal-article" @default.
- W2129119177 hasAuthorship W2129119177A5002754020 @default.
- W2129119177 hasAuthorship W2129119177A5014953513 @default.
- W2129119177 hasAuthorship W2129119177A5017437213 @default.
- W2129119177 hasAuthorship W2129119177A5059469170 @default.
- W2129119177 hasAuthorship W2129119177A5062155936 @default.
- W2129119177 hasAuthorship W2129119177A5077854816 @default.
- W2129119177 hasBestOaLocation W21291191771 @default.
- W2129119177 hasConcept C118552586 @default.
- W2129119177 hasConcept C126322002 @default.
- W2129119177 hasConcept C14216870 @default.
- W2129119177 hasConcept C142724271 @default.
- W2129119177 hasConcept C15744967 @default.
- W2129119177 hasConcept C160798450 @default.
- W2129119177 hasConcept C169900460 @default.
- W2129119177 hasConcept C180747234 @default.
- W2129119177 hasConcept C199360897 @default.
- W2129119177 hasConcept C2778186239 @default.
- W2129119177 hasConcept C2778641062 @default.
- W2129119177 hasConcept C2779134260 @default.
- W2129119177 hasConcept C2779140760 @default.
- W2129119177 hasConcept C2779422653 @default.
- W2129119177 hasConcept C2779483572 @default.
- W2129119177 hasConcept C2780046773 @default.
- W2129119177 hasConcept C2781099131 @default.
- W2129119177 hasConcept C41008148 @default.
- W2129119177 hasConcept C71924100 @default.
- W2129119177 hasConcept C83852419 @default.
- W2129119177 hasConceptScore W2129119177C118552586 @default.
- W2129119177 hasConceptScore W2129119177C126322002 @default.
- W2129119177 hasConceptScore W2129119177C14216870 @default.
- W2129119177 hasConceptScore W2129119177C142724271 @default.
- W2129119177 hasConceptScore W2129119177C15744967 @default.
- W2129119177 hasConceptScore W2129119177C160798450 @default.
- W2129119177 hasConceptScore W2129119177C169900460 @default.
- W2129119177 hasConceptScore W2129119177C180747234 @default.
- W2129119177 hasConceptScore W2129119177C199360897 @default.
- W2129119177 hasConceptScore W2129119177C2778186239 @default.
- W2129119177 hasConceptScore W2129119177C2778641062 @default.
- W2129119177 hasConceptScore W2129119177C2779134260 @default.
- W2129119177 hasConceptScore W2129119177C2779140760 @default.
- W2129119177 hasConceptScore W2129119177C2779422653 @default.
- W2129119177 hasConceptScore W2129119177C2779483572 @default.
- W2129119177 hasConceptScore W2129119177C2780046773 @default.