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- W2129120310 abstract "The flexibility and conformality of radiation doses achieved with brachytherapy over highly curvaceous undulating clinical target superficial surfaces is not well documented. In this study we present results achieved Dose fidelity and conformality for High-dose-rate Surface Applicator Brachytherapy for cutaneous lymphoma lesions of the hands and feet using high-dose-rate surface applicator brachytherapy. Here is presented a cohort of 6 consecutive patients (8 lesions) with clinically and pathologically proven CTCL lesions of the hands and feet. As these sites of CTCL can be very clinically challenging for both cosmetic and functional endpoints, there is a strong and growing clinical need to have very expedient successful palliative solutions. Whereas it is usually sufficient to use electron fields for flat clinical superficial targets, the conformality of dose over highly curvaceous and undulating surfaces is suboptimal and can lead to clinical failures with attendant consequences. For a cohort of 6 consecutive patients (8 lesions) dose was recorded at the skin surface, 3 mm depth (100%) and the depth of the 50% isodose line across the applicator. Within the Clinical Target Area (CTA) the clinical target volume (CTV) is the volume within the CTA to 3mm in depth. The planned maximum surface dose was less than 125% of the prescribed dose. The 3 mm depth dose was uniformly and conformally 100%. The depth of the 50% was typically within the first centimeters of tissue. Rapid improvement, clinical clearance and minimal to no cutaneous toxicity were observed for all of the lesions. No evidence of recurrence has been observed with after a mean followup of 15.8 months (10.3-23.3 months). This experience highlights the potential of high-dose-rate surface applicator brachytherapy to treat CTCL of the hands and feet. These results warrant further investigation in a multi-institutional environment. The reproduction of this technique relies on minimizing hotspots to the skin surface (< 125% prescribed dose) and ensuring uniform coverage of the of the CTV." @default.
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- W2129120310 date "2014-03-01" @default.
- W2129120310 modified "2023-10-18" @default.
- W2129120310 title "Dose Fidelity and Conformality for High-Dose-Rate Surface Applicator Brachytherapy for Cutaneous Lymphoma Lesions of the Hands and Feet" @default.
- W2129120310 doi "https://doi.org/10.1016/j.brachy.2014.02.405" @default.
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