FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129120791> ?p ?o ?g. }

• W2129120791 endingPage "4075" @default.
• W2129120791 startingPage "4066" @default.
• W2129120791 abstract "Androgens are essential for development and differentiated function, as well as proliferation and survival of cells within the prostate gland. Age-related changes in the hormonal milieu, marked by a decrease in the serum androgen to estrogen ratio may contribute to the evolution of pathological changes, such as benign prostatic hyperplasia and carcinoma of the prostate gland, in older men. A similar phenomenon occurs in Brown Norway rats, in which the serum testosterone to estradiol ratio declines with age, and despite the lower serum testosterone level, age-dependent prostatic hyperplasia develops in the dorsal and lateral lobes, but not in the ventral lobe. To evaluate a role for changes in androgen action in the evolution of prostatic hyperplasia, we compared the immunostaining intensity of androgen receptor in the different prostate lobes from young (4 months of age) and old (24 months of age) Brown Norway rats. Androgen receptor immunostaining was present in the nuclei of all epithelial cells and some stromal cells throughout the prostatic ducts of each lobe from both young and old rats. Whereas androgen receptor immunostaining intensity decreased in luminal epithelial cells of the ventral prostate from old rats, it increased in luminal epithelial cells of the dorsal and lateral lobes from old rats, when compared with young rats. To validate immunocytochemical studies, Western blot analyses were performed. The total tissue level of androgen receptor decreased by 30% in the ventral lobe of old rats, whereas tissue levels of androgen receptor increased 2.7-fold and 1.3-fold in the dorsal and lateral lobes, respectively, of old rats. Similarly, the percentage of epithelial cells staining positive for the proliferation marker, proliferating cell nuclear antigen, was increased approximately 2-fold in the dorsal and lateral lobes as a function of older age. The presence of higher levels of androgen receptor and increased number of proliferating cell nuclear antigen-positive cells in the dorsal and lateral lobes of old rats suggest that changes in androgen receptor levels may be related to the lobe-specific proliferation of cells that occurs with increasing age. Additional evidence for lobe-specific regulation of androgen receptor expression was obtained from Western blots and by immunocytochemistry following castration. Androgen receptor levels in the ventral and dorsal lobes, but not the lateral lobe, of young and old rats were down-regulated in the absence of testicular androgen. However, nuclear immunostaining of androgen receptor returned by 7–10 d after castration in the ventral and dorsal lobes in the continued absence of androgen. Moreover, up-regulation of the androgen receptor level occurred more rapidly in the ventral and dorsal lobes of old, compared with young, castrated rats. Taken together, these results suggest that lobe-specific and age-dependent differences in the regulation of androgen receptor expression might lead to changes in tissue androgen responsiveness and the consequent development of lobe-specific hyperplasia in the Brown Norway rat prostate gland." @default.
• W2129120791 created "2016-06-24" @default.
• W2129120791 creator A5016227237 @default.
• W2129120791 creator A5019249921 @default.
• W2129120791 creator A5088516029 @default.
• W2129120791 date "2001-09-01" @default.
• W2129120791 modified "2023-10-14" @default.
• W2129120791 title "Increased Androgen Receptor Expression Correlates with Development of Age-Dependent, Lobe-Specific Spontaneous Hyperplasia of the Brown Norway Rat Prostate" @default.
• W2129120791 cites W1489626592 @default.
• W2129120791 cites W1529553588 @default.
• W2129120791 cites W1540547861 @default.
• W2129120791 cites W1553656745 @default.
• W2129120791 cites W1566803289 @default.
• W2129120791 cites W1567343129 @default.
• W2129120791 cites W1599958658 @default.
• W2129120791 cites W17086092 @default.
• W2129120791 cites W1948931726 @default.
• W2129120791 cites W1965768875 @default.
• W2129120791 cites W1974667009 @default.
• W2129120791 cites W1980067078 @default.
• W2129120791 cites W1981237194 @default.
• W2129120791 cites W1984440848 @default.
• W2129120791 cites W1984784419 @default.
• W2129120791 cites W1985726477 @default.
• W2129120791 cites W1986929503 @default.
• W2129120791 cites W1987609643 @default.
• W2129120791 cites W1990781244 @default.
• W2129120791 cites W1991404942 @default.
• W2129120791 cites W1995142571 @default.
• W2129120791 cites W2001349528 @default.
• W2129120791 cites W2003845408 @default.
• W2129120791 cites W2017700331 @default.
• W2129120791 cites W2025098190 @default.
• W2129120791 cites W2033017094 @default.
• W2129120791 cites W2034816211 @default.
• W2129120791 cites W2041440450 @default.
• W2129120791 cites W2042571781 @default.
• W2129120791 cites W2044253657 @default.
• W2129120791 cites W2055320276 @default.
• W2129120791 cites W2057770598 @default.
• W2129120791 cites W2069972733 @default.
• W2129120791 cites W2076901754 @default.
• W2129120791 cites W2077021300 @default.
• W2129120791 cites W2081735878 @default.
• W2129120791 cites W2082682054 @default.
• W2129120791 cites W2092291647 @default.
• W2129120791 cites W2095378062 @default.
• W2129120791 cites W2100837269 @default.
• W2129120791 cites W2101108802 @default.
• W2129120791 cites W2103759127 @default.
• W2129120791 cites W2116892539 @default.
• W2129120791 cites W2140402602 @default.
• W2129120791 cites W2157020937 @default.
• W2129120791 cites W2160365040 @default.
• W2129120791 cites W2160920731 @default.
• W2129120791 cites W2162671228 @default.
• W2129120791 cites W2187176260 @default.
• W2129120791 cites W2267247859 @default.
• W2129120791 cites W2309414991 @default.
• W2129120791 cites W2396626466 @default.
• W2129120791 cites W2402676250 @default.
• W2129120791 cites W2409671375 @default.
• W2129120791 cites W2415033560 @default.
• W2129120791 cites W2417371006 @default.
• W2129120791 doi "https://doi.org/10.1210/endo.142.9.8376" @default.
• W2129120791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11517186" @default.
• W2129120791 hasPublicationYear "2001" @default.
• W2129120791 type Work @default.
• W2129120791 sameAs 2129120791 @default.
• W2129120791 citedByCount "65" @default.
• W2129120791 countsByYear W21291207912012 @default.
• W2129120791 countsByYear W21291207912013 @default.
• W2129120791 countsByYear W21291207912014 @default.
• W2129120791 countsByYear W21291207912015 @default.
• W2129120791 countsByYear W21291207912016 @default.
• W2129120791 countsByYear W21291207912017 @default.
• W2129120791 countsByYear W21291207912018 @default.
• W2129120791 countsByYear W21291207912019 @default.
• W2129120791 countsByYear W21291207912020 @default.
• W2129120791 countsByYear W21291207912022 @default.
• W2129120791 crossrefType "journal-article" @default.
• W2129120791 hasAuthorship W2129120791A5016227237 @default.
• W2129120791 hasAuthorship W2129120791A5019249921 @default.
• W2129120791 hasAuthorship W2129120791A5088516029 @default.
• W2129120791 hasBestOaLocation W21291207911 @default.
• W2129120791 hasConcept C121608353 @default.
• W2129120791 hasConcept C126322002 @default.
• W2129120791 hasConcept C134018914 @default.
• W2129120791 hasConcept C16930146 @default.
• W2129120791 hasConcept C204232928 @default.
• W2129120791 hasConcept C2776235491 @default.
• W2129120791 hasConcept C2777562237 @default.
• W2129120791 hasConcept C2777911890 @default.
• W2129120791 hasConcept C2779279991 @default.
• W2129120791 hasConcept C2780192828 @default.
• W2129120791 hasConcept C4224716 @default.
• W2129120791 hasConcept C530470458 @default.
• W2129120791 hasConcept C61367390 @default.

• next