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- W2129124972 abstract "Bioassay-guided fractionation of the active BuOH extract of the sea cucumber Pseudocolochirus violaceus resulted in the isolation of three new sulfated triterpene glycosides, i.e., violaceusides I, II, and III (1–3, resp.), as active compounds causing morphological abnormality of Pyricularia oryzae mycelia. Their structures were elucidated by spectroscopic methods including 2D-NMR and MS experiments, as well as chemical evidence. Compounds 1–3 exhibit the same structural features, i.e., the presence of a 16-oxo group in the holostane-type triterpene aglycone with the C(7)C(8) bond, but differ in the side chains and the tetrasaccharide moieties. Compound 1 possesses one sulfate group, while 2 and 3 are disulfated glycosides. All the glycosides showed significant in vitro cytotoxicities against human gastric cancer MKN-45 and human colon cancer HCT-116 cells." @default.
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- W2129124972 date "2006-07-01" @default.
- W2129124972 modified "2023-10-10" @default.
- W2129124972 title "Cytotoxic Sulfated Triterpene Glycosides from the Sea CucumberPseudocolochirus violaceus" @default.
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- W2129124972 doi "https://doi.org/10.1002/cbdv.200690083" @default.
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